Vitamin D insufficienty and the occurrence of musculoskeletal diseases and disability: A population-based cohort ROAD

• Project/Area Number: 24659317
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Public health/Health science
• Research Institution: The University of Tokyo
• Principal Investigator: YOSHIMURA Noriko 東京大学, 医学部附属病院, 准教授 (60240355)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takao 国立長寿医療センター研究所, 所長 (30154545) ; AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助手 (60401064) ; MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任助手 (40401070)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 医療・福祉 / ビタミンD不足 / 骨粗鬆症 / 変形性関節症 / 要介護 / 危険因子 / コホート調査 / ビタミンＤ不足症 / 血清25(OH)D値 / コホート研究 / 国際比較 / 国際情報交換(英国) / ビタミンD不足症 / 疫学 / 国際情報交換（英国）

Outline of Final Research Achievements

In this population-based cohort study, assessments of serum 25-hydroxyvitamin D (25D) levels revealed vitamin D insufficiency and deficiency at prevalances of 81.3% and 1.2%, respectively. Serum 25D levels could predict the occurrence of osteoporosis within 3 years, but not the occurrence of osteoarthritis. The mean (SD) annual change in the serum 25 D levels was 7.6 (13.3) %/year, which tended to increase during the 3-year period. Multivariate regression analysis indicated that the L2-4 bone mineral density and total daily energy intake were significant independent associated factors.

Research Products

• [Journal Article] Serum levels of 25-hydroxyvitamin D and occurrence of musculoskeletal diseases, such as osteoporosis, knee osteoarthritis and lumbar spondylosis: A three-year follow-up of the road study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 1 Pages: 151-161
  • DOI: 10.1007/s00198-014-2844-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mutual associations among musculoskeletal diseases and metabolic syndrome components: A 3-year follow-up of the ROAD study (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Mod Rheumatol Volume: in press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women. (2014)
  • Author(s): Tanaka S, Kuroda T, Yamazaki Y, Shiraki Y, Yoshimura N, Shiraki M
  • Journal Title: J Bone Miner Metab Volume: 32 Issue: 5 Pages: 524-532
  • DOI: 10.1007/s00774-013-0520-3
  • Peer Reviewed / Open Access
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: Geriatr Gerontol Int Volume: 14 Issue: 3 Pages: 695-701
  • DOI: 10.1007/s00776-014-0537-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Issue: 1 Pages: 104-110
  • DOI: 10.1016/j.joca.2013.10.019
  • Peer Reviewed
• [Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Nishiwaki Y, Shimizu Y, Yoshida H, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: in press
  • Peer Reviewed
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. (2014)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: in press
  • Peer Reviewed
• [Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 24 Issue: 11 Pages: 2775-2787
  • DOI: 10.1007/s00198-013-2372-z
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study. (2013)
  • Author(s): Muraki S
  • Journal Title: Bone Volume: 52 Issue: 1 Pages: 516-523
  • DOI: 10.1016/j.bone.2012.10.020
  • Peer Reviewed
• [Journal Article] Impact of nutrition on muscle mass, strength, and performance in older adults. (2013)
  • Author(s): Mithal A, Boonen S, Bonjour J-P, Burckhardt P, Degens H, Hajj Fuleihan G El, Josse R, Lips P, Morales Torres J, Rizzoli R, Yoshimura N, Wahl DA, Cooper C, Dawson-Hughes B for the IOF CSA Nutrition Working Group
  • Journal Title: Osteoporos Int Volume: 24 Pages: 1555-1566
  • Peer Reviewed
• [Journal Article] Consuming breakfast and exercising longer during high school increases bone mineral density in young Japanese men. (2013)
  • Author(s): Ishimoto Y, Yoshida M, Nagata K, Yamada H, Hashizume H, Yoshimura N
  • Journal Title: J Bone Miner Metab Volume: 31 Issue: 3 Pages: 329-336
  • DOI: 10.1007/s00774-012-0415-8
  • Peer Reviewed
• [Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: A longitudinal cohort study. Osteoporosis Int (inpress) Volume: 21(Epub ahead of print) Issue: 2 Pages: 459-466
  • DOI: 10.1007/s00198-012-1967-0
  • Peer Reviewed
• [Journal Article] Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study. (2012)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Tanaka S, and Akune T
  • Journal Title: BMJ Open (in press) Volume: 2 Issue: 6 Pages: 2001520-2001520
  • DOI: 10.1136/bmjopen-2012-001520
  • Peer Reviewed
• [Journal Article] Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. (2012)
  • Author(s): Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Issue: 11 Pages: 1217-1226
  • DOI: 10.1016/j.joca.2012.06.006
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: a longitudinal population-based cohort study. (2012)
  • Author(s): Muraki S, Tokimura F
  • Journal Title: Arthritis Rheum. Volume: 64(5) Issue: 5 Pages: 1147-56
  • DOI: 10.1002/art.33508
  • Peer Reviewed
• [Journal Article] Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women: the ROAD study. (2012)
  • Author(s): Muraki S, Tokimura F
  • Journal Title: Osteoarthritis Cartilage. Volume: 20(7) Issue: 7 Pages: 712-8
  • DOI: 10.1016/j.joca.2012.03.009
  • Peer Reviewed
• [Presentation] Association between diffuse idiopathic skeletal hyperostosis, bone mineral density, and CTX2: The ROAD study (2015)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N
  • Organizer: Annual Meeting of American Academy of Orthopedic Surgeons
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2015-03-24 – 2015-03-28
• [Presentation] Dose Osteophytosis at the Knee Predict Health-related Quality of Life Decline? A 3-Years follow-up of the ROAD Study. (2014)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Organizer: The European League Against Rheumatism (EULAR) 2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Mutual associations among musculoskeletal diseases, metabolic syndrome, and cognitive impairment: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The European League Against Rheumatism (EULAR) 2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Assessment of joint destruction at the knee in rheumatoid arthritis using semi-automated software for magnetic resonance image analysis (2014)
  • Author(s): Oka H, Ohashi S, Kadono Y, Yasui T, Ono K, Isawa K, Yoshimura N, Nishino J, Tanaka S
  • Organizer: The European League Against Rheumatism (EULAR) 2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Mutual associations among diseases causing disability, such as musculoskeletal diseases, metabolic syndrome components, and mild cognitive impairment: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The Annual Congress of European Calcified Tissue Society (ECTS) 2014
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2014-05-17 – 2014-05-20
• [Presentation] Osteoarthritis: Assessment of clinical and structural outcomes. (2013)
  • Author(s): Yoshimura N
  • Organizer: IOF Regionals -4th Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Hong Kong
  • Invited
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: The ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: European Congress on Osteoporosis and Osteoarthritis
  • Place of Presentation: Rome, Italy
• [Presentation] Higher levels of serum 25(OH)D prevents the occurrence of osteoporosis, but deteriorates knee osteoarthritis: A 3-year follow-up of the ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Tanaka S, Kawaguchi H, Akune T
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
• [Presentation] Risk factors for multiple falls in Japanese men and women: The ROAD Study. (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura, K, Oka H, Yoshimura N
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR)
  • Place of Presentation: Kobe, Japan
• [Presentation] Prevalence of sarcopenia and its association with exercise habits in the elderly of Japanese population-based cohorts: The ROAD Study. (2013)
  • Author(s): Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Organizer: IOF Regionals -4th Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Hong Kong
• [Presentation] Accumulation of metabolic risk factors raises the risk of occurrence and progression of knee osteoarthritis: the ROAD study. (2012)
  • Author(s): Yoshimura N
  • Organizer: Annual European Congress of Rheumatology (EULAR) 2012
  • Place of Presentation: Berlin, Germany
• [Presentation] Mild Cognitive Impairment Increases The Risk of Knee Osteoarthritis: A 3-Year Follow-Up in The ROAD Study. (2012)
  • Author(s): Yoshimura N
  • Organizer: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and women: The ROAD Study. (2012)
  • Author(s): Muraki S
  • Organizer: IOF Regionals - 3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Book] インフォームドコンセントのための図説シリーズ 骨粗鬆症 改訂3版 (2015)
  • Author(s): 吉村典子(分担執筆）
  • Total Pages: 83
  • Publisher: 医薬ジャーナル社
• [Book] 骨ペディア.骨疾患・骨代謝キーワード事典 (2015)
  • Author(s): 吉村典子(分担執筆）
  • Total Pages: 128
  • Publisher: 羊土社
• [Book] 骨粗鬆症の予防と治療ガイドライン2015年版 (2015)
  • Author(s): 吉村典子(分担執筆）
  • Publisher: ライフサイエンス出版
• [Book] 変形性膝関節症の運動療法ガイド－保存的治療から術後リハまで (2014)
  • Author(s): 吉村典子(分担執筆）
  • Total Pages: 219
  • Publisher: 日本医事新報社
• [Book] ロコモティブシンドローム (2014)
  • Author(s): 吉村典子(分担執筆）
  • Publisher: メディカルレビュー社
• [Book] 変形性膝関節症の運動療法ガイド－保存的治療から術後リハまで (2014)
  • Author(s): 吉村典子(分担執筆)
  • Publisher: 日本医事新報社
• [Book] II. 骨粗鬆症の疫学 2. 骨折の疫学 3) 非脊椎骨折（大腿骨頚部骨折を除く）「骨粗鬆症診療ハンドブック改訂５版」 (2012)
  • Author(s): 吉村典子
  • Publisher: 医薬ジャーナル社
• [Book] ロコモティブシンドロームの疫学．ロコモティブシンドロームと栄養 (2012)
  • Author(s): 吉村典子
  • Publisher: 建帛社