| Project/Area Number |
24659317
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takao 国立長寿医療センター研究所, 所長 (30154545)
AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662)
OKA Hiroyuki 東京大学, 医学部附属病院, 特任助手 (60401064)
MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任助手 (40401070)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 医療・福祉 / ビタミンD不足 / 骨粗鬆症 / 変形性関節症 / 要介護 / 危険因子 / コホート調査 / ビタミンＤ不足症 / 血清25(OH)D値 / コホート研究 / 国際比較 / 国際情報交換(英国) / ビタミンD不足症 / 疫学 / 国際情報交換（英国） |
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| Outline of Final Research Achievements |
In this population-based cohort study, assessments of serum 25-hydroxyvitamin D (25D) levels revealed vitamin D insufficiency and deficiency at prevalances of 81.3% and 1.2%, respectively. Serum 25D levels could predict the occurrence of osteoporosis within 3 years, but not the occurrence of osteoarthritis. The mean (SD) annual change in the serum 25 D levels was 7.6 (13.3) %/year, which tended to increase during the 3-year period. Multivariate regression analysis indicated that the L2-4 bone mineral density and total daily energy intake were significant independent associated factors.
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