Trends in Intraparenchymal Hemorrhage Subtypes and Its Risk Factors.

• Project/Area Number: 24659321
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Fukushima Medical University
• Principal Investigator: OHIRA Tetsuya 福島県立医科大学, 医学部, 教授 (50448031)
• Co-Investigator(Kenkyū-buntansha): YAMAGISHI Kazumasa 筑波大学, 医学医療系, 講師 (20375504) ; KITAMURA Akihiko 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター, 予防推進部・循環器病・その他部局等, その他 (80450922) ; IMANO Hironori 大阪大学, 医学研究科, 助教 (90450923) ; EGUCHI Eri 愛媛大学, 医学研究科, 講師 (60635118)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 疫学 / 脳出血 / 推移 / 前向き研究 / 危険因子 / 脳内出血 / トレンド / 病型 / 高血圧 / 低コレステロール / 飲酒

Research Abstract

The incidence of intraparenchymal hemorrhage (IPH) from 1986 to 2010 was ascertained by systematic surveillance in three Japanese Communities. The incidence of deep IPH has tended to have increased from 1986 to 2010, while the incidence of lobar and cerebellar IPH has been flat.
A prospective study of Japanese subjects aged 40-69 years was undertaken using data collected from 9,086 participants in cardiovascular risk surveys conducted in three communities between 1985 and 1994. The incidence of IPH between 1985 and 2010 was ascertained by systematic surveillance. During an average follow up of 20.5-years, 144 incident IPHs occurred. Systolic blood pressure, body mass index, major ST-T abnormality on electrocardiogram, and excess ethanol intake (>=46g/day) were associated with increased risk of deep ICH, while serum total cholesterol levels were inversely associated with incidence of lobar and cerebellar IPH, even after adjustment for potential confounding variables.

Research Products

• [Journal Article] An association between central aortic pressure and subclinical organ damage of the heart among a general Japanese cohort : Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): Cui R, Li Y, K Gero, Yamagishi K, Umesawa M, Imano H, Ohira T, Kiyama M, Okada T, Kitamura A, Hitsumoto S, Tanigawa T, Iso H.
  • Journal Title: Atherosclerosis Volume: 232 Pages: 94-8
• [Journal Article] Adult height and body mass index in relation to risk of total stroke and its subtypes : the Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): Shimizu Y, Imano H, Ohira T, Kitamura A, Kiyama M, Okada T, Ishikawa Y, Shimamoto T, Yamagishi K, Tanigawa T, Iso H.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 23 Pages: 667-674
• [Journal Article] Heavy alcohol consumption and risk of atrial fibrillation : Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): Sano F, Ohira T, Kitamura A, Imano H, Cui R, Kiyama M, Okada T, Yamagishi K, Sankai T, Tanigawa T, Kario K, Iso H.
  • Journal Title: Circ J Volume: 78 Pages: 955-961
  • NAID: 130003391047
  • Peer Reviewed
• [Journal Article] CIRCS Investigators. High-density lipoprotein subclasses and risk of stroke and its subtypes in Japanese population : the Circulatory Risk in Communities Study (2013)
  • Author(s): Chei CL, Yamagishi K, Kitamura A, Kiyama M, Imano H, Ohira T, Cui R, Tanigawa T, Sankai T, Ishikawa Y, Sato S, Hitsumoto S, Iso H.
  • Journal Title: Stroke Volume: 44 Pages: 327-333
• [Journal Article] Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels (2013)
  • Author(s): Saito I, Yamagishi K, Chei CL, Cui R, Ohira T, Kitamura A, Kiyama M, Imano H, Okada T, Kato T, Hitsumoto S, Ishikawa Y, Tanigawa T, Iso H.
  • Journal Title: Atherosclerosis Volume: 229 Pages: 222-227
• [Journal Article] Alkaline Phosphatase (ALP) and risk of stroke among Japanese : The Circulatory Risk in Communities Study (CIRCS) (2013)
  • Author(s): Shimizu Y, Imano H, Ohira T, Kitamura A, Kiyama M, Okada T, Ishikawa Y, Shimamoto T, Yamagishi K, Tanigawa T, Iso H.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 22 Pages: 1046-1055
• [Journal Article] Cardiovascular disease epidemiology in Asia: an overview. (2013)
  • Author(s): Ohira T, Iso H.
  • Journal Title: Circ J Volume: 77 Pages: 1646-1652
  • NAID: 10031173739
  • Peer Reviewed
• [Journal Article] Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels. (2013)
  • Author(s): Saito I, Yamagishi K, Chei CL, Cui R, Ohira T, Kitamura A, Kiyama M, Imano I, Okada T, Kato T, Hitsumoto S, Ishikawa Y, Tanigawa T, Iso H.
  • Journal Title: Atherosclerosis Volume: 229 Issue: 1 Pages: 222-227
  • DOI: 10.1016/j.atherosclerosis.2013.04.014
  • Peer Reviewed
• [Journal Article] High-density lipoprotein subclasses and risk of stroke and its subtypes in Japanese population: the Circulatory Risk in Communities Study. (2013)
  • Author(s): Chei CL
  • Journal Title: Stroke Volume: 44 Issue: 2 Pages: 327-333
  • DOI: 10.1161/strokeaha.112.674812
  • Peer Reviewed
• [Presentation] 脳出血の部位別にみた危険因子の検討 : the Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): 大平哲也、今野弘規、江口依里、北村明彦、木山昌彦、山岸良匡、山海知子、崔仁哲、岡田武夫、梅澤光政、谷川武、磯博康
  • Organizer: 日本疫学会総会
  • Place of Presentation: 仙台
• [Presentation] 脳出血の部位別にみた危険因子の検討: the Circulatory Risk in Communities Study (CIRCS) (2014)
  • Author(s): 大平哲也
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台
• [Presentation] for the CIRCS investigators. Risk Factors for intraparenchymal hemorrhage subtypes : the Circulatory Risk in Communities Study (CIRCS) (2013)
  • Author(s): Ohira T, Eguchi E, Imano H, Kitamura A, Kiyama M, Yamagishi K, Sankai T, Cui R, Okada T, Tanigawa T, Ishikawa Y, Iso H.
  • Organizer: American Heart Association 53th Annual Conference on Cardiovascular Disease Epidemiology and Prevention
  • Place of Presentation: New Orleans, LA
• [Presentation] for the CIRCS investigators. Trends in Hemorrhagic Stroke in Japan, from 1986 to 2010 : Circulatory Risk in Communities Study (CIRCS) (2013)
  • Author(s): Eguchi E, Ohira T, Imano H, Kitamura A, Kiyama M, Okada T, Yamagishi K, Sankai T, Umesawa M, Cui R, Maruyama M, Tanigawa T, Ishikawa Y, Iso H.
  • Organizer: American Heart Association 53th Annual Conference on Cardiovascular Disease Epidemiology and Prevention
  • Place of Presentation: Orleans, LA
• [Presentation] Risk factors for intraparenchymal hemorrhage subtypes: the Circulatory Risk in Communities Study (CIRCS). (2013)
  • Author(s): Ohira T
  • Organizer: American Heart Association 53th Annual Conference on Cardiovascular Disease Epidemiology and Prevention
  • Place of Presentation: New Orleans
• [Presentation] Trends in hemorrhagic stroke in Japan, from 1986 to 2010: the Circulatory Risk in Communities Study (CIRCS). (2013)
  • Author(s): Eguchi E
  • Organizer: American Heart Association 53th Annual Conference on Cardiovascular Disease Epidemiology and Prevention
  • Place of Presentation: New Orleans