The predictive ability of endogenous secretory receptor for advanced glycation end products for fragility Fractures and cardiovascular diseases.

• Project/Area Number: 24659332
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Osaka Medical College (2013); Kinki University (2012)
• Principal Investigator: TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356)
• Co-Investigator(Kenkyū-buntansha): IKI Masayuki 近畿大学, 医学部, 教授 (50184388) ; SATO Yuho 仁愛大学, 生活科学学科, 教授 (10337115) ; KOUDA Katsuyasu 近畿大学, 医学部, 准教授 (60273182)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 成人保健 / 骨折 / 循環器疾患

Research Abstract

We conducted the 5-year follow-up survey of FORMEN Study which enrolled 2012 men at the baseline, as part of a prospective cohort study of Fujiwara-kyo study. There was no significant difference in esRAGE values at the baseline survey in men who suffered coronary artery diseases when compared to men who did not. The higher values of esRAGE were significantly correlated with the lower values of intima-media thickness of carotid artery (IMT) measured at the 5-year follow-up survey, while there was no significant correlation between esRAGE- to pentosidine ratio and IMT values. Higher values of esRAGE-to-pentosidine ratio were associated with a decreased risk of fragility fractures independently of age and BMD among Japanese elderly men.

Research Products

• [Journal Article] Renal function and bone mineral density in community-dwelling elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2013)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Bone Volume: 56 Issue: 1 Pages: 61-66
  • DOI: 10.1016/j.bone.2013.05.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population : FORMEN Study (2011)
  • Author(s): Iki M, Tamaki J, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int Volume: 23 Issue: 2 Pages: 761-770
  • DOI: 10.1007/s00198-011-1600-7
  • Peer Reviewed
• [Journal Article] Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men : the FORMEN study (2011)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int Volume: 23 Issue: 2 Pages: 705-714
  • DOI: 10.1007/s00198-011-1594-1
  • Peer Reviewed
• [Presentation] 男性骨粗鬆症コホート研究5年次追跡による脆弱性骨折のリスク要因の検討-FORMEN Study (2013)
  • Author(s): 玉置淳子
  • Organizer: 第72回日本公衆衛生学会総会
  • Place of Presentation: 三重
  • Year and Date: 2013-10-23
• [Presentation] Serum Pentosidine and its Decoy Receptor, endogenous secretory receptor for Advanced Glycation End Products, Predict Fragility Fractures in Elderly Men : the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study (2013)
  • Author(s): Tamaki J.
  • Organizer: ASBMR 2013 Annual Meeting
  • Place of Presentation: Baltimore, Maryland, USA
  • Year and Date: 2013-10-04
• [Presentation] INCIDENT CLINICAL FRACTURE INCREASES THE RISK OF MORTALITY IN COMMUNITY-DWELLING ELDERLY MEN : FUJIWARA-KYO OSTEOPOROSIS RISK IN MEN (FORMEN) STUDY (2012)
  • Author(s): Iki M.
  • Organizer: the IOF Regionals–3rd Asia-Pacific Osteoporosis Meeting
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2012-12-13
• [Presentation] 高齢男性の新規骨折は生命予後を悪化させる : 藤原京スタディ男性骨粗鬆症研究 (2012)
  • Author(s): 伊木雅之
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口
  • Year and Date: 2012-10-24
• [Presentation] Serum Pentosidine and its Decoy receptor, endogenous secretory receptor for Advanced Glycation End products, Predict Fragility Fractures in Elderly Men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study
  • Author(s): Junko TAMAKI, Katsuyasu KOUDA, Yuki FUJITA, Masayuki IKI, Akiko YURA, Eiko KADOWAKI, Masakazu MIURA, Yuho SATO, Nozomi OKAMOTO, Norio KURUMATANI
  • Organizer: ASBMR
  • Place of Presentation: ボルチモア、アメリカ合衆国