| Project/Area Number |
24659334
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Ken-ichi 東京大学, 大学院医学系研究科, 教授 (40166947)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 心筋梗塞 / ミトコンドリア / カルパイン / mPTP / Complex I / カルシウム |
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| Research Abstract |
Opening of the mitochondrial permeability transition pore (mPTP) is involved in ischemia-reperfusion injury. Isoforms of Ca2+-activated cysteine proteases, calpains, are implicated in the development of myocardial infarction in ischemia-reperfusion. We demonstrated for the first time the presence of mitochondrial calpain, and the contribution to Complex I inactivation and mPTP opening after postischemic reperfusion in heart.
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