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A correct assessment of myocardial infarction

Research Project

Project/Area Number 24659334
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

SHINTANI-ISHIDA Kaori  東京大学, 医学(系)研究科(研究院), 講師 (50345047)

Co-Investigator(Renkei-kenkyūsha) YOSHIDA Ken-ichi  東京大学, 大学院医学系研究科, 教授 (40166947)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords心筋梗塞 / ミトコンドリア / カルパイン / mPTP / Complex I / カルシウム
Research Abstract

Opening of the mitochondrial permeability transition pore (mPTP) is involved in ischemia-reperfusion injury. Isoforms of Ca2+-activated cysteine proteases, calpains, are implicated in the development of myocardial infarction in ischemia-reperfusion. We demonstrated for the first time the presence of mitochondrial calpain, and the contribution to Complex I inactivation and mPTP opening after postischemic reperfusion in heart.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats2014

    • Author(s)
      Shintani-Ishida K, Saka K, Yamaguchi K, Hayashida M, Nagai H, Takemura G, Yoshida K
    • Journal Title

      Biochimca et Biophysica Acta

      Volume: 1842 Issue: 5 Pages: 691-700

    • DOI

      10.1016/j.bbadis.2014.01.013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Connexin-43 hemichannels contribute to the propagation of μ-calpain-mediated neuronal death in a cortical ablation injury model.2013

    • Author(s)
      Ishii Y, Shintani-Ishida K, Yoshida K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Issue: 2 Pages: 457-462

    • DOI

      10.1016/j.bbrc.2013.10.091

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic humanlivers2013

    • Author(s)
      Kashima J, Shintani-Ishida K, Nakajima M, Maeda H, Unuma K, Uchiyama Y, Yoshida K
    • Journal Title

      Hepatol Res

      Volume: 413 Issue: 7 Pages: 779-787

    • DOI

      10.1111/hepr.12183

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart2013

    • Author(s)
      Hideyuki Maeda, Hisashi Nagai, GenzouTakemura, Masaaki Komatsu, Sayoko Ogura, Kaori Shintani-Ishida, Toshihiko Aki, Mikiyasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
    • Journal Title

      Biochimicaet Biophysica Acta

      Volume: 1832 Issue: 8 Pages: 1159-1166

    • DOI

      10.1016/j.bbadis.2013.02.014

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemia-reperfusion induces myocardial infarction through mitochondrial Ca^2+ overload2012

    • Author(s)
      Shintani-Ishida, K., Inui, M., and Yoshida, K
    • Journal Title

      J. Mol. Cell. Cardiol

      Volume: 53 Issue: 2 Pages: 233-239

    • DOI

      10.1016/j.yjmcc.2012.05.012

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] MDMA及びその活性代謝物(DHMA,DHA)のLC-MS/MSを用いた同時定量分析2013

    • Author(s)
      坂幹樹,新谷香,山口晃志,林田眞喜子,大野曜吉,吉田謙一
    • Organizer
      第82回日本法医学会学術関東地方集会
    • Place of Presentation
      はまぎんホールヴィアマーレ(横浜)
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] α2受容体シグナルとストレスによる心収縮不全の関連2013

    • Author(s)
      黒田亮平,新谷香,永井恒志,前田秀将,吉田謙一
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2013 Final Research Report
  • [Presentation] Heart failure induced by intermittent hypoxia in rat fed high-fat diet2013

    • Author(s)
      前田秀将,永井恒志,山口るつ子,加島淳平,新谷香,吉田謙一
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2013 Final Research Report
  • [Presentation] Mitochondrial calpains contribute to opening of mitochondrial permeability transition pore in ischemia-reperfusion2013

    • Author(s)
      Shintani-Ishida K, Yoshida K.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Final Research Report
  • [Presentation] α2受容体シグナルとストレスによる心収縮不全の関連2013

    • Author(s)
      黒田亮平,新谷香,永井恒志,前田秀将,吉田謙一
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heart failure induced by intermittent hypoxia in rat fed high-fat diet2013

    • Author(s)
      前田秀将,永井恒志,山口るつ子,加島淳平,新谷香,吉田謙一
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mitochondrial calpains contribute to opening of mitochondrial permeability transition pore in ischemia-reperfusion.2013

    • Author(s)
      Shintani-Ishida K, Yoshida K
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 睡眠時無呼吸症候群・糖尿病合併モデルラットにおける心機能低下2012

    • Author(s)
      奈良明奈,永井恒志,加島淳平,前田秀将,黒田亮平,Lisa Wingenfeld,新谷香,吉田謙一
    • Organizer
      第81回日本法医学会学術関東地方会
    • Place of Presentation
      高崎シティーギャラリー(高崎)
    • Year and Date
      2012-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] MDMAはeNOS活性化を介して酸化ストレスによる心機能低下を惹起する2012

    • Author(s)
      新谷香,坂幹樹,石井康博,中嶋信,吉田謙一
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティー浜松(浜松)
    • Related Report
      2013 Final Research Report
  • [Presentation] Intermittent hypoxia induces autophagy to prevent heart failure in rats2012

    • Author(s)
      前田秀将,永井恒志,新谷香,Lisa Wingenfeld,吉田謙一
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティー浜松(浜松)
    • Related Report
      2013 Final Research Report
  • [Presentation] Immobilization stress causes the transient cardiac contractile deficiency in rat2012

    • Author(s)
      黒田亮平,前田秀将,永井恒志,新谷香,吉田謙一
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティー浜松(浜松)
    • Related Report
      2013 Final Research Report
  • [Presentation] MDMA及びその活性代謝物(DHMA,DHA)のLC-MS/MSを用いた同時定量分析

    • Author(s)
      坂幹樹,新谷香,山口晃志,林田眞喜子,大野曜吉,吉田 謙一
    • Organizer
      第82回日本法医学会学術関東地方集会
    • Place of Presentation
      はまぎんホールヴィアマーレ(横浜)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東大法医学教室ホームページ

    • URL

      http://plaza.umin.ac.jp/~forensic/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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