| Project/Area Number |
24659341
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATAKE Katsuhiko 奈良県立医科大学, 医学部, 教授 (40164842)
MARUMO Mikio 兵庫医科大学, 医学部, 講師 (40333950)
TAKEDA Yuji 山形大学, 医学部, 助教 (90302299)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アルコール / 循環動態 / 血圧 / フラッシング / ペプチドーム解析 / プロテアーゼ / フラッシング反応 |
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| Research Abstract |
In order to clarify the mechanism for the action of alcohol on the circulatory system, we tried to find the peptides that change in relation to blood pressure after alcohol drinking. Blood pressure significantly decreased at 45 minutes after drinking, and the decrease in blood pressure was still observed at 2 ~ 3 hours after drinking. Drinking caused a significant decrease in levels of the peptides with m/z 2662 and m/z 2380 and a significant increase in a level of the peptide with m/z 1467. The peptides with m/z 1467 and m/z 2662 were identified to be parts of fibrinogen alpha chain, while the peptide with m/z 2380 was identified to be a part of complement 4a. The peptides with m/z 1467 and m/z 2662 were the same as the peptides that have been reported to change after abstinence in chronic alcoholic patients.
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