Pathophysiology of gastrointestinal perception in functional gastroduodenal disorder
| Project/Area Number |
24659345
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 機能性ディスペプシア / 消化管知覚 / 脳構造 / 情動 / Voxel-based morphometry / MRI / 認知 / Visceral Sensitivity / Brain Connectivity / structural MRI / Barostat / stress / 機能性消化管消化管障害 / 消化管内臓知覚 / 脳腸相関 / 脳領域間結合 / 消化管内臓知覚異常 / Diffuse Tensor Imaging / Connectome / 機能性胃腸症 |
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| Outline of Final Research Achievements |
This research tested the hypothesis that structural change of brain was the pathophysiological basis of gastrointestinal visceral hypersensitivity. Subjects with functional dyspepsia (FD) and healthy control were carried out brain structural MRI scanning. Brain imaging analysis was performed by Voxel-Based Morphometry (VBM) using SPM12 with the self-rating scores of gastrointestinal symptom and psychological states as covariance. There was a difference in right superior orbitofrontal cortex, left inferior temporal gyrus and right precuneus between FD and control. There was a correlation between psychological state and left lingual gyrus and between abdominal symptom and middle temporal gyrus. These results suggested that structural changes of specific brain area related to visceral sensation and emotional network would be the pathophysiological basis for characteristics of gastrointestinal visceral hypersensitivity.
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Report
(5 results)
Research Products
(10 results)
