Establishment of disease iPS cells and molecular analysis of age-related changes in progeroid syndrome

• Project/Area Number: 24659346
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Chiba University
• Principal Investigator: YOKOTE Koutaro 千葉大学, 医学(系)研究科(研究院), 教授 (20312944)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Takahiko 千葉大学, 大学院医学研究院, 寄附講座教員 (40301791)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: Werner症候群 / iPS細胞 / 早老症候群 / 老化 / 遺伝子発現

Research Abstract

Werner syndrome (WS) is a progeroid disorder caused by mutations in the WRN gene, which encodes a RecQ type DNA helicase. In order to clarify molecular mechanism of pathogenesis of WS, we gene-transferred Yamanaka's four factors, such as Oct-4, Sox2, Klf4, c-Myc, into skin fibroblasts of WS patients. We isolated iPS clone cells and confirmed them with highly proliferative ability as well as pluripotency, indicating establishment of WS iPS cells by reprogramming. Furthermore, we investigated the protective effect of read-thorough drugs on WS fibroblasts with a nonsense mutation and discussed the therapeutic potentiality of the drugs to WS.

Research Products

• [Journal Article] Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with T2DM inadequately controlled on sulfonylurea alone (SUCCESS-2): a multicenter, randomized, open-label, non-inferiority trial. (2014)
  • Author(s): Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S,Yokote K, on behalf of the SUCCESS Study Group.
  • Journal Title: Diabetes, Obesity and Metabolism Volume: - Issue: 8 Pages: 761-765
  • DOI: 10.1111/dom.12264
  • Peer Reviewed
• [Journal Article] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. (2013)
  • Author(s): Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A.
  • Journal Title: The Journal of Experimental Medicine Volume: 210(12) Issue: 12 Pages: 2627-39
  • DOI: 10.1084/jem.20131144
  • Peer Reviewed
• [Journal Article] Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis. (2013)
  • Author(s): Watanabe K, Shibuya S, Koyama H, Ozawa Y, Toda T, Yokote K, Shimizu T.
  • Journal Title: International Journal of Molecular Sciences Volume: 14(6) Issue: 6 Pages: 10998-11010
  • DOI: 10.3390/ijms140610998
  • Peer Reviewed
• [Journal Article] Sitagliptin Improves Postprandial Hyperglycemia by Inhibiting Glucagon Secretion in Werner Syndrom With Diabetes. (2013)
  • Author(s): Watanabe K, Kobayashi K, Takemoto M, Ishibashi R, Yamaga M, Kawamura H, Fujimoto M, Ishikawa T, Ohnishi S, Okabe E, Peng He, Yokote K.
  • Journal Title: Diabetes Care Volume: ‐ Issue: 8 Pages: e119-e119
  • DOI: 10.2337/dc13-0709
  • Peer Reviewed
• [Journal Article] Executive Summary of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan —2012 Version (2013)
  • Author(s): Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama c, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 6 Pages: 517-523
  • DOI: 10.5551/jat.15792
  • NAID: 130004845437
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Metabplic predictions of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age. (2013)
  • Author(s): Hayashi T, Araki A, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Kubota K, Noda M, Noto H, Ina K, Nomura H; Japan CDM group
  • Journal Title: Cardiovasc Diabetol Volume: - Issue: 1 Pages: 10-10
  • DOI: 10.1186/1475-2840-12-10
  • Peer Reviewed
• [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma (2013)
  • Author(s): Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
  • Journal Title: Br J Haematol Volume: 163(2) Issue: 2 Pages: 277-280
  • DOI: 10.1111/bjh.12467
  • Peer Reviewed
• [Journal Article] Distinct Roles for CXCR6+ and CXCR6- CD4+ T Cells in the Pathogenesis of Chronic Colitis (2013)
  • Author(s): Mandai Y, Takahashi D, Hase K, Obata Y, Furusawa Y, Ebisawa M, Nakagawa T, Sato T, Katsuno T, Saito Y, Shimaoka T, Yokosuka O, Yokote K, Ohno H
  • Journal Title: PloS One Volume: 8(6) Issue: 6 Pages: e65488-e65488
  • DOI: 10.1371/journal.pone.0065488
  • Peer Reviewed
• [Journal Article] Detection of adrenal veins on selective retrograde CT adrenal venography in comparison with digital subtraction angiography in subjects with established diagnosis of one-sided adrenal aldosterone- producing tumor confirmed by adrenal vein sampling, histopathology and clinical course. (2013)
  • Author(s): Higashide T, Funabashi N, Yanaka T, Inoue K, Kazama T, Motoori K, Nagano H, Takaoka H, Uehara M, Nishiyama A, Kato H, Yokote K, Kobayashi Y, Uno T.
  • Journal Title: Int J Cardiol Volume: 168(4) Issue: 4 Pages: 3254-3258
  • DOI: 10.1016/j.ijcard.2013.04.140
  • Peer Reviewed
• [Journal Article] Utility of 320 slice mapping CT for adrenal vein sampling in subjects suspected of having primary-aldosteronism compared with digital -subtraction-angiography and selective retrograde CT adrenal venography. (2013)
  • Author(s): Higashide T, Funabashi N, Tanaka T, Inoue K, Kazama T, Motoori K, Nagano H, Takaoka H, Uehara M, Nishiyama A, Kato H, Yokote K, Kobayashi Y, Uno T.
  • Journal Title: Int J Cardiol Volume: 168(3) Issue: 3 Pages: 3033-3034
  • DOI: 10.1016/j.ijcard.2013.04.143
  • Peer Reviewed
• [Journal Article] 日本人2型糖尿病患者に対するインスリン分泌促進系薬剤の臨床検討-DPP-4阻害薬シタブリプチンとSU薬グリメピリドの1年間比較- (2013)
  • Author(s): 栗林伸一、澤梨乃、横手幸太郎
  • Journal Title: Therapeutic Research Volume: 34(4) Pages: 521-530
• [Journal Article] 糖尿病患者におけるしびれ症状の発現頻度について-外来患者122例を対象としたアンケート調査に基づく解析- (2013)
  • Author(s): 竹本稔、小林一貴、河村治清、横手幸太郎
  • Journal Title: Therapeutic Research Volume: 34(4) Pages: 531-537
• [Journal Article] Alteration of VEGF and Angiopoietins expressions in diabetic glomeruli implicated in the development of diabetic nephropathy. (2013)
  • Author(s): Sonezaki K
  • Journal Title: dvanced Studies in Medical Sciences Volume: 1 Pages: 11-28
  • Peer Reviewed
• [Journal Article] Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy: The Japan Diabetes Complications Study. (2013)
  • Author(s): Kawasaki R
  • Journal Title: Opthalmology Volume: 120 Pages: 574-582
  • Peer Reviewed
• [Journal Article] Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey. (2013)
  • Author(s): Takemoto M
  • Journal Title: Geriatr Gerontol Int Volume: 13 Pages: 475-481
  • Peer Reviewed
• [Journal Article] Incidence and characteristics of metabolic disorders and vascular complications in Werner syndrome patients in Japan (2012)
  • Author(s): Okabe E, Takemoto M, Onishi S, Ishikawa T, Ishibashi R, He P, Kobayashi K, Fujimoto M, Kawamura H, Yokote K
  • Journal Title: J Am Geriatr Soc Volume: 60(5) Issue: 5 Pages: 997-998
  • DOI: 10.1111/j.1532-5415.2012.03944.x
  • Peer Reviewed
• [Journal Article] Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer. (2012)
  • Author(s): Onishi S
  • Journal Title: Acta Diabetol Volume: 49 Issue: S1 Pages: 259-260
  • DOI: 10.1007/s00592-012-0424-z
  • Peer Reviewed
• [Journal Article] Sitagliptin successfully ameliorates glycemic control in werner syndrome with diabetes (2012)
  • Author(s): Kitamoto T, Takemoto M, Fujimoto M, Ishikawa T, Onishi S, Okabe E, Ishibashi R, Kobayashi K, Kawamura H, Yokote K
  • Journal Title: Diabetes Care Volume: Diabetes Care Issue: 12 Pages: e83-e83
  • DOI: 10.2337/dc12-1179
  • Peer Reviewed
• [Journal Article] A case of Werner syndrome without metabolic abnormality : Implications for the early pathophysiology (2012)
  • Author(s): Takada-Watanabe A, Yokote K, Takemoto M, Fujimoto M, Irisuna H, Honjo S, Futami K, Furuichi Y, Saito Y.
  • Journal Title: Geriat Gerontol Int Volume: 12(1) Issue: 1 Pages: 140-146
  • DOI: 10.1111/j.1447-0594.2011.00743.x
  • Peer Reviewed
• [Journal Article] Comparison of Various Lipid Variables as Predictors of Coronary Heart Disease in Japanese Men and Women with Type 2 Diabetes. Subanalysis of the Japan Diabetes Complications Study (JDCS) (2012)
  • Author(s): Sone H, Tanaka S, Tanaka S, Iimuro S, Ishibashi S, Oikawa S, Shimano H, Katayama S, Ohashi Y, Akanuma Y, Yamada N
  • Journal Title: Diabetes Care Volume: (in press) Issue: 5 Pages: 1150-1157
  • DOI: 10.2337/dc11-1412
  • Peer Reviewed
• [Journal Article] The role of the hypoxia-inducible factor 1 binding site in the induction of aquaporin-1 mRNA expression by hypoxia. (2012)
  • Author(s): Tanaka A
  • Journal Title: DNA Cell Biol Volume: 30(8) Pages: 539-544
  • Peer Reviewed
• [Journal Article] Smad3 contributes to positioning of proliferating cells in colonic crypts by inducing EphB receptor protein expression. (2012)
  • Author(s): Furukawa K
  • Journal Title: Biochem Biophys Res Commun Volume: 405(4) Pages: 521-526
  • Peer Reviewed
• [Journal Article] Factors associated with the efficiency of PBSC collection in POEMS syndrome patients undergoing autologous PBSC transplantation. (2012)
  • Author(s): Shimizu N
  • Journal Title: Bone Marrow Transplantation Volume: 47 Pages: 1010-1012
  • Peer Reviewed
• [Journal Article] Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice (2012)
  • Author(s): Koshizaka M, Takemoto M, Sato S, Tokuyama H, Fujimoto M, Okabe E, Ishibashi R, Ishikawa T, Tsurutani Y, Onishi S, Mezawa M, He P, Honjo S, Ueda S, Saito Y, Yokote K
  • Journal Title: Exp Diabetes Res Volume: 1 Pages: 159874-159874
  • DOI: 10.1155/2012/159874
  • Peer Reviewed
• [Journal Article] Incidence and characteristics of metabolic disorders and vascular complications in individuals with Werner syndrome in Japan. (2012)
  • Author(s): Okabe E
  • Journal Title: J Am Geriatr Soc Volume: 60(5) Pages: 997-998
  • Peer Reviewed
• [Journal Article] Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor. (2012)
  • Author(s): Shimizu N
  • Journal Title: Bone Marrow Transplant Volume: 47(12) Pages: 1587-1588
  • Peer Reviewed
• [Journal Article] Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. (2012)
  • Author(s): Tanaka S
  • Journal Title: Blood Volume: 120(5) Pages: 1107-1017
  • Peer Reviewed
• [Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias. (2012)
  • Author(s): Sakai S
  • Journal Title: Clin Chim Acta Volume: 413 Pages: 1542-1548
  • Peer Reviewed
• [Journal Article] The reduced form of coenzyme Q10 improves glycemic control in patients with type 2 diabetes: An open label pilot study. (2012)
  • Author(s): Mezawa M
  • Journal Title: Biofactors Volume: 38(6) Pages: 416-421
  • Peer Reviewed
• [Journal Article] The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. (2012)
  • Author(s): Matsumoto T
  • Journal Title: Eur J Pharmacol Volume: 685 Pages: 213-217
  • Peer Reviewed
• [Journal Article] Intestinal epithelial cells with impaired autophagy lose their adhesive capacity in the presence of TNF-α. (2012)
  • Author(s): Saito M
  • Journal Title: Dig Dis Sci Volume: 57(8) Pages: 2022-2030
  • Peer Reviewed
• [Journal Article] Posterior reversible encephalopathy syndrome in an adult patient with acute lymphoblastic leukemia after remission induction chemotherapy. (2012)
  • Author(s): Tsukamoto S
  • Journal Title: Int J Hematol Volume: 95(2) Pages: 204-208
  • Peer Reviewed
• [Journal Article] Severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone developed as initial manifestation of human herpesvirus-6-associated acute limbic encephalitis after unrelated bone marrow transplantation. (2012)
  • Author(s): Kawaguchi T
  • Journal Title: Transpl Infect Dis Volume: 15 Issue: 2
  • DOI: 10.1111/tid.12029
  • Peer Reviewed
• [Journal Article] Multicenter Study to Determine the Diagnosis Criteria of Heterozygous Familial Hypercholesterolemia in Japan. (2012)
  • Author(s): Harada-Shiba M
  • Journal Title: J Atheroscler Thromb Volume: 19(11) Pages: 1019-1026
  • Peer Reviewed
• [Journal Article] Guidelines for the Management of Familial Hypercholesterolemia. (2012)
  • Author(s): Harada-Shiba M
  • Journal Title: J Atheroscler Thromb Volume: 19 (12) Pages: 1043-1060
  • Peer Reviewed
• [Presentation] Achievement of Healthy Aging : from a Japanese Medical Point of View (2013)
  • Author(s): Yokote, K.
  • Organizer: China Medical University
  • Place of Presentation: Shenyang, China
  • Year and Date: 2013-11-05
  • Invited
• [Presentation] Multidisciplinary approach for the treatment of diabetes in the elderly (2013)
  • Author(s): Yokote, K.
  • Organizer: 4^<th> International Association of Gerontology and Geriatrics Master Class on Ageing-Kyoto
  • Place of Presentation: Kyoto
  • Year and Date: 2013-10-30
  • Invited
• [Presentation] (シンポジスト)New diagnostic criteria and treatment guideline for werner syndrome (2013)
  • Author(s): Yokote, K.
  • Organizer: The 20^<th> IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Seoul Korea
  • Year and Date: 2013-06-25
• [Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeroid syndrome (2013)
  • Author(s): Shimizu, T., Koyama, H., Shibuya, S., Shimamoto, A., Takemoto, M., Yokote, K.
  • Organizer: The 20^<th> IAGG World Congress of Gerontology and Geriatrics (IAGG 2013)
  • Place of Presentation: Seoul Korea
• [Presentation] Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer (2013)
  • Author(s): Onishi, S., Takemoto, M., Ishikawa, T., Okabe, E., Ishibashi, R., He, P., Kobayashi, K., Fujimoto, M., Kawamura, H., Yokote, K.
  • Organizer: 20th World Congress of the International Association of Gerontology and Geriatrics (IAGG2013)
  • Place of Presentation: Seoul, Korea
• [Presentation] Incidence and characteristics of metabolic disorders and vascular complications in Werner syndrome patients in Japan (2013)
  • Author(s): Okabe, E., Onishi, S., Takemoto, M., Ishikawa, T., Ishibashi, R., He, P., Kobayashi, K., Fujimoto, M., Kawamura, H., Yokote, K.
  • Organizer: 20th World Congress of the International Association of Gerontology and Geriatrics (IAGG2013)
  • Place of Presentation: Seoul, Korea
• [Presentation] Achievement of healthy aging : from a Japanese medical point of view (2013)
  • Author(s): Yokote, K.
  • Organizer: The 1st meeting for JST-VINNOVA Scoping Group for university-industry collaboration program
  • Place of Presentation: Tokyo
• [Presentation] Mission of medical research in aging society (2012)
  • Author(s): Yokote, K.
  • Organizer: Kaohsiung Medical University (高雄医学大学)
  • Place of Presentation: Taiwan
  • Year and Date: 2012-05-03
  • Invited
• [Presentation] Marked Increase of Plasma Fibroblast Growth Factor 21 in Dyslipidemic Patients and Specific Peroxisome Proliferator Activated Receptor Alpha Agonist.
  • Author(s): Yokote, K
  • Organizer: American Heart Association Scientific Sessions 2013
  • Place of Presentation: Dallas Convention Center(米国、ダラス)
• [Presentation] Achievement of Healthy Aging: from a Japanese Medical Point of View.
  • Author(s): Yokote, K
  • Organizer: China Medical University
  • Place of Presentation: 中国医科大学(上海、中国)
  • Invited
• [Presentation] Multidisciplinary approach for the treatment of diabetes in the elderly.
  • Author(s): Yokote, K
  • Organizer: 4th International Association of Gerontology and Geriatrics Master Class on Ageing-Kyoto
  • Place of Presentation: kyoto international community house(京都府京都市))
  • Invited
• [Presentation] Treatment of dyslipidemia in postmenopausal women.
  • Author(s): Yokote, K
  • Organizer: The 5th Scientific Meeting of the Asia Pacific Menopause Federation Luncheon Seminar 4
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
• [Presentation] APSAVD Statement on the Management of Lipids for Prevention of Cardiovascular Diseases.
  • Author(s): Yokote, K
  • Organizer: APSAVD-JAS Joint Symposium
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Invited
• [Presentation] New diagnostic criteria and treatment guideline for werner syndrome.
  • Author(s): Yokote, K
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: COEX(韓国、ソウル)
• [Presentation] Oxidative stress, aging and progeric syndrome. Recent progress in basic and clinical research on progeric syndrome.
  • Author(s): Takahiko Shimizu, Hirofumi Koyama, Shuichi Shibuya, Akira Shimamoto, Minoru Takemoto, Koutaro Yokote.
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: COEX(韓国、ソウル)
• [Presentation] Atherosclerosis as a reluctant failure of the protective vascular response.
  • Author(s): Yokote, K
  • Organizer: The 1st Symposium of Leading Graduate School at Chiba University Immune System Regulation and Innovative Therapeutics
  • Place of Presentation: Station Conference Tokyo(東京都千代田区)
• [Presentation] 糖尿病における脂質異常症の治療戦略
  • Author(s): 横手幸太郎
  • Organizer: 第51回日本糖尿病学会関東甲信越地方会共催セミナー
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
• [Presentation] 健康長寿を目指す糖尿病治療
  • Author(s): 横手幸太郎
  • Organizer: 第48回日本成人病（生活習慣病）学会学術集会共催セミナー
  • Place of Presentation: 都市センターホテル(東京都千代田区)
• [Presentation] 未病としての脂質異常と管理のポイント
  • Author(s): 横手幸太郎
  • Organizer: 第20回日本未病システム学会学術総会共催セミナー
  • Place of Presentation: 学術総合センター(東京都千代田区)
• [Presentation] 心血管イベント予防を考慮した2型糖尿病の治療戦略
  • Author(s): 横手幸太郎
  • Organizer: 第34回日本肥満学会共催セミナー
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
• [Presentation] 高齢者の脂質異常症:evidence and experience
  • Author(s): 横手幸太郎
  • Organizer: 第58回日本老年医学会関東甲信越地方会
  • Place of Presentation: 武田薬品工業(東京都中央区)
  • Invited
• [Presentation] 早老症から学ぶ生活習慣病と動脈硬化
  • Author(s): 横手幸太郎
  • Organizer: 動脈硬化Update2013
  • Place of Presentation: 御殿山ガーデンホテルラフォーレ東京(東京都品川区)
• [Presentation] 総合診療医のための脂質異常症～診断と治療のUpdate～
  • Author(s): 横手幸太郎
  • Organizer: 第7回日本病院総合診療医学会学術総会
  • Place of Presentation: ホテルグランビア広島(広島県広島市)
• [Presentation] 動脈硬化予防のための糖尿病治療～メトホルミンへの新たな期待を含めて～
  • Author(s): 横手幸太郎
  • Organizer: 第45回日本動脈効果学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
• [Presentation] 早老症の病態と幹細胞
  • Author(s): 横手幸太郎、清水孝彦、竹本稔
  • Organizer: 第13回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Invited
• [Presentation] 高齢者の糖尿病治療とインクレチン製剤の位置づけ
  • Author(s): 横手幸太郎
  • Organizer: 第28回日本老年学会総会 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪国際会場(大阪府大阪市)
• [Presentation] 高齢者糖尿病の臨床的特徴～他疾患との関わりも含めて～
  • Author(s): 横手幸太郎
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテル日航熊本(熊本県熊本市)
• [Presentation] 動脈硬化をどう防ぐか？脂肪酸の可能性を踏まえて
  • Author(s): 横手幸太郎
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市民会館(熊本県熊本市)
• [Presentation] LDL-C80のサイドから
  • Author(s): 横手幸太郎
  • Organizer: 第56回日本糖尿病学会年次学術集会総会
  • Place of Presentation: 熊本市民会館(熊本)
• [Presentation] 高齢者の糖尿病治療とインクレチン製剤の位置づけ
  • Author(s): 横手幸太郎
  • Organizer: 第30回日本臨床内科医会総会
  • Place of Presentation: 東京商工会議所(東京都千代田区)
• [Presentation] 脂質異常症
  • Author(s): 横手幸太郎
  • Organizer: 第47回日本成人病（生活習慣病）学会学術集会
  • Place of Presentation: 都市センターホール(東京)
• [Presentation] Lipid management guideline in A-P region.
  • Author(s): Yokote K
  • Organizer: 8th Congress of Asian-Pacific Society of Atherosclerosis and Vascular Diseases
  • Place of Presentation: Hilton Phuket Arcadia Resort and Spa( Thailand)
• [Presentation] Familial hypercholesterolemia, model of care in Asian-Pacific region.
  • Author(s): Yokote K
  • Organizer: 8th Congress of Asian-Pacific Society of Atherosclerosis and Vascular Diseases
  • Place of Presentation: Hilton Phuket Arcadia Resort and Spa( Thailand)
• [Presentation] Cellular regulation in diabetic complications.
  • Author(s): Yokote K
  • Organizer: 2012 Shanghai Symposium on Obesity and Diabetes
  • Place of Presentation: Chinese Academy of Sciences(China)
  • Invited
• [Book] 老年医学系統講義テキスト編集日本老年医学会 (2013)
  • Author(s): 横手幸太郎, 他
  • Total Pages: 328
  • Publisher: 西村書店
• [Book] NHKきょうの健康本気で動脈硬化予防!コレステロール対策 (2013)
  • Author(s): 横手幸太郎
  • Publisher: NHK出版
• [Book] コレステロール治療の常識と非常識 (2012)
  • Author(s): 桑島巌、横手幸太郎
  • Publisher: 角川マガジンズ
• [Remarks] ウエルナー症候群の診療ガイドライン2012
  • URL: http://www.m.chiba-u.ac.jp/class/clin-cellbiol/index.html