How do Kampo formulations work?
| Project/Area Number |
24659348
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
SAIKI Ikuo 富山大学, 和漢医薬学総合研究所, 教授 (80133776)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Satoru 富山大学, 和漢医薬学総合研究所, 助教 (90613498)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 漢方薬 / 構成生薬 / 細胞内シグナル |
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| Outline of Final Research Achievements |
Kampo formulations comprise a number of crude natural drugs/herbs as constituents. The crude drugs/herbs have been traditionally classified by their traditional classifications or efficacies in Kampo medicines; however, it has been difficult to establish the scientific link between experimental evidence and traditional classifications in Kampo medicine.
Consideringour results supported by the grant, the traditional categories of crude drugs/herbs in Kampo medicine may be positively associated with the effects on intracellular signaling using reporter assay unless there are significant differences in their botanical origin and active constituents. Alternatively, our results imply that the crude drugs/herbs belonging to the same category in Kampo medicine share a common effect on intracellular signaling activity in vitro.
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Report
(4 results)
Research Products
(108 results)
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[Journal Article] TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.2015
Author(s)
Xue R, Han N, Xia M, Ye C, Hao Z, Wang L, Wang Y, Yang J, Saiki I, Yin J.
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Journal Title
Steroids
Volume: 94
Pages: 51-59
DOI
Related Report
Peer Reviewed
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[Journal Article] Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.2015
Author(s)
Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M.S., Koizumi K., Yokoyama S., Saiki I., and Sakurai H.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 458
Issue: 4
Pages: 856-861
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2014
Author(s)
Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
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Journal Title
BMC Cancer.
Volume: 14
Issue: 1
Pages: 949-949
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation.2013
Author(s)
Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.
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Journal Title
Cancer Science
Volume: 104
Issue: 10
Pages: 1315-1322
DOI
Related Report
Peer Reviewed
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[Journal Article] A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.2013
Author(s)
Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S, Svasti J, Saiki I.
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Journal Title
Oncol Rep.
Volume: 30
Issue: 5
Pages: 2357-2364
DOI
Related Report
Peer Reviewed
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[Journal Article] The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination.2013
Author(s)
Saiki I, Koizumi K, Goto H, Inujima A, Namiki T, Raimura M, Kogure T, Tatsumi T, Inoue H, Sakai S, Oka H, Fujimoto M, Hikiami H, Sakurai H, Shibahara N, Shimada Y, Origasa H.
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Journal Title
Evid Based Complement Alternat Med.
Volume: 2013
Pages: 568074-568074
DOI
Related Report
Peer Reviewed
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