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How do Kampo formulations work?

Research Project

Project/Area Number 24659348
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of Toyama

Principal Investigator

SAIKI Ikuo  富山大学, 和漢医薬学総合研究所, 教授 (80133776)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Satoru  富山大学, 和漢医薬学総合研究所, 助教 (90613498)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords漢方薬 / 構成生薬 / 細胞内シグナル
Outline of Final Research Achievements

Kampo formulations comprise a number of crude natural drugs/herbs as constituents. The crude drugs/herbs have been traditionally classified by their traditional classifications or efficacies in Kampo medicines; however, it has been difficult to establish the scientific link between experimental evidence and traditional classifications in Kampo medicine.
Consideringour results supported by the grant, the traditional categories of crude drugs/herbs in Kampo medicine may be positively associated with the effects on intracellular signaling using reporter assay unless there are significant differences in their botanical origin and active constituents. Alternatively, our results imply that the crude drugs/herbs belonging to the same category in Kampo medicine share a common effect on intracellular signaling activity in vitro.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (108 results)

All 2015 2014 2013 2012 Other

All Journal Article (41 results) (of which Peer Reviewed: 41 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (63 results) (of which Invited: 10 results) Book (1 results) Remarks (3 results)

  • [Journal Article] TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.2015

    • Author(s)
      Xue R, Han N, Xia M, Ye C, Hao Z, Wang L, Wang Y, Yang J, Saiki I, Yin J.
    • Journal Title

      Steroids

      Volume: 94 Pages: 51-59

    • DOI

      10.1016/j.steroids.2014.12.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer2015

    • Author(s)
      Toge M, Yokoyama S, Kato S, Sakurai H, Senda K, Doki Y, Hayakawa Y, Yoshimura N, Saiki I
    • Journal Title

      Int. J. Oncol.

      Volume: 46 Issue: 4 Pages: 1844-1848

    • DOI

      10.3892/ijo.2015.2861

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage.2015

    • Author(s)
      Lou C, Yokoyama S, Saiki I, Hayakawa Y.
    • Journal Title

      Oncol Rep.

      Volume: 33 Issue: 4 Pages: 2072-2076

    • DOI

      10.3892/or.2015.3796

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.2015

    • Author(s)
      Refaat A., Aminullah, Zhou Y., Kawanishi M., Tomaru R., Abdelhamed S., Shin M.S., Koizumi K., Yokoyama S., Saiki I., and Sakurai H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 458 Issue: 4 Pages: 856-861

    • DOI

      10.1016/j.bbrc.2015.02.044

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-inflammatory Effect of Cinnamaldehyde in <i>Helicobacter pylori</i> Induced Gastric Inflammation2015

    • Author(s)
      Muhammad JS, Zaidi SF, Shaharyar S, Refaat A, Usmanghani K, Saiki I, Sugiyama T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 1 Pages: 109-115

    • DOI

      10.1248/bpb.b14-00609

    • NAID

      130004872218

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of keishibukuryogan on genetic and dietary obesity models.2015

    • Author(s)
      Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y.
    • Journal Title

      Evid Based Complement Alternat Med.

      Volume: 2015 Pages: 801291-801291

    • NAID

      120006389608

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small cell lung cancer2014

    • Author(s)
      Kaneto N, Yokoyama S, Hayakawa Y, Kato S, Sakurai H, Saiki I
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 7 Pages: 788-794

    • DOI

      10.1111/cas.12425

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis.2014

    • Author(s)
      Habibie, Yokoyama S, Abdelhamed S, Awale S, Sakurai H, Hayakawa Y, Saiki I.
    • Journal Title

      Int J Oncol.

      Volume: 45 Pages: 895-901

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-kB activation2014

    • Author(s)
      Chenghua Lou, Kei Takahashi, Tatsuro Irimura, Ikuo Saiki and Yoshihiro Hayakawa
    • Journal Title

      International Journal of Oncology

      Volume: 45 Issue: 5 Pages: 2085-2091

    • DOI

      10.3892/ijo.2014.2624

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.2014

    • Author(s)
      Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.
    • Journal Title

      BMC Cancer.

      Volume: 14 Issue: 1 Pages: 949-949

    • DOI

      10.1186/1471-2407-14-949

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.2014

    • Author(s)
      Kee JY, Inujima A, Andoh T, Tanaka K, Li F, Kuraishi Y, Sakurai H, Shibahara N, Saiki I, Koizumi K.
    • Journal Title

      J Nat Med.

      Volume: 69 Issue: 2 Pages: 209-217

    • DOI

      10.1007/s11418-014-0880-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.2014

    • Author(s)
      Zhou Y., Tanaka T., Sugiyama N., Yokoyama S., Kawasaki Y., Sakuma T., Ishihama Y., Saiki I., and Sakurai H.
    • Journal Title

      FEBS Letters

      Volume: 588 Issue: 1 Pages: 131-137

    • DOI

      10.1016/j.febslet.2013.11.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique.2014

    • Author(s)
      Yurika Saitoh, Nobuo Terada, Nobuhiko Ohno, Akiei Hamano, Nobuo Okumura, Takashi Jin, Ikuo Saiki, Shinichi Ohno
    • Journal Title

      Microvasc. Res.

      Volume: 91 Pages: 73-83

    • DOI

      10.1016/j.mvr.2013.11.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B2014

    • Author(s)
      Kato S, Hayakawa Y, Sakurai H, Saiki I, Yokoyama S
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 3 Pages: 281-289

    • DOI

      10.1111/cas.12336

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] (+)-Grandifloracin, a novel Antiausterity Agent, Induces Autophagic PANC-1 Pancreatic Cancer Cell Death.2014

    • Author(s)
      Ueda J., Athikomkulchai S., Miyatake R., Saiki I, Esumi H., Awale S.
    • Journal Title

      Drug Des. Dev. Ther.

      Volume: 8 Pages: 39-47

    • DOI

      10.2147/dddt.s52168

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the "in vivo cryotechnique".2014

    • Author(s)
      Lei T, Huang Z, Ohno N, Wu B, Sakoh T, Saitoh Y, Saiki I, Ohno S.
    • Journal Title

      J Histochem Cytochem.

      Volume: 62 Issue: 4 Pages: 251-264

    • DOI

      10.1369/0022155413520313

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Piperine Enhances the Efficacy of TRAIL-based Therapy for Triple-negative Breast Cancer Cells.2014

    • Author(s)
      Abdelhamed S, Yokoyama S, Refaat A, Ogura K, Yagita H, Awale S, Saiki I.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 1893-1899

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation.2013

    • Author(s)
      Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, Awale S, Ruchirawat S, Svasti J, Saiki I.
    • Journal Title

      Int J Oncol.

      Volume: 43 Issue: 1 Pages: 329-337

    • DOI

      10.3892/ijo.2013.1926

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationships studies of brartemicin analogs as anti-invasive agents.2013

    • Author(s)
      Jiang YL, Miyanaga S, Han XZ, Tang LQ, Igarashi Y, Saiki I, Liu ZP.
    • Journal Title

      J Antibiot (Tokyo).

      Volume: 66 Issue: 9 Pages: 531-537

    • DOI

      10.1038/ja.2013.37

    • NAID

      10031201648

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation.2013

    • Author(s)
      Sato K., Shin M.S., Sakimura A., Zhou Y., Tanaka T., Kawanishi M., Kawasaki Y., Yokoyama S., Koizumi K., Saiki I., and Sakurai H.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 10 Pages: 1315-1322

    • DOI

      10.1111/cas.12225

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp.2013

    • Author(s)
      Shirouzu T, Watari K, Ono M, Koizumi K, Saiki I, Tanaka C, van Soest RW, Miyamoto T.
    • Journal Title

      J Nat Prod.

      Volume: 76 Issue: 7 Pages: 1337-1342

    • DOI

      10.1021/np400297p

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.2013

    • Author(s)
      Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S, Svasti J, Saiki I.
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 5 Pages: 2357-2364

    • DOI

      10.3892/or.2013.2667

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress.2013

    • Author(s)
      Li P, Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Zhao QL, Saiki I, Kondo T.
    • Journal Title

      Int J Hyperthermia.

      Volume: 29 Issue: 7 Pages: 688-695

    • DOI

      10.3109/02656736.2013.828104

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer.2013

    • Author(s)
      Refaat A, Abdelhamed S, Yagita H, Inoue H, Yokoyama S, Hayakawa Y, Saiki I.
    • Journal Title

      Oncol Lett. 2013 Sep;6(3):840-844. Epub 2013 Jul 1.

      Volume: 6 Pages: 840-844

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epitheli al-to-mesenchymal transition in the A549 lung cancer cell line2013

    • Author(s)
      Kin R, Kato S, Kaneto N, Sakurai H, Hayakawa Y, Li F, Tanaka K, Saiki I, Yokoyama S
    • Journal Title

      International Journal of Oncology

      Volume: 43 Issue: 6 Pages: 1901-1906

    • DOI

      10.3892/ijo.2013.2139

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel.2013

    • Author(s)
      Bahar MA, Andoh T, Ogura K, Hayakawa Y, Saiki I, Kuraishi Y.
    • Journal Title

      Evid Based Complement Alternat Med.

      Volume: 2013 Pages: 849754-849754

    • DOI

      10.1155/2013/849754

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination.2013

    • Author(s)
      Saiki I, Koizumi K, Goto H, Inujima A, Namiki T, Raimura M, Kogure T, Tatsumi T, Inoue H, Sakai S, Oka H, Fujimoto M, Hikiami H, Sakurai H, Shibahara N, Shimada Y, Origasa H.
    • Journal Title

      Evid Based Complement Alternat Med.

      Volume: 2013 Pages: 568074-568074

    • DOI

      10.1155/2013/568074

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper.2013

    • Author(s)
      Li F, Tanaka K, Watanabe S, Tezuka Y, Saiki I.
    • Journal Title

      Chem Pharm Bull (Tokyo).

      Volume: 61 Pages: 1318-1322

    • NAID

      130003381796

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of plant extracts sensitizing breast cancer cells to TRAIL.2013

    • Author(s)
      Abdelhamed S, Yokoyama S, Hafiyani L, Kalauni SK, Hayakawa Y, Awale S, Saiki I.
    • Journal Title

      Oncology Reports

      Volume: 29 Issue: 5 Pages: 1991-1998

    • DOI

      10.3892/or.2013.2293

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-KB pathway to induce metastatic potential2013

    • Author(s)
      Kei Takahashi, Kazuyoshi Takeda, Ikuo Saiki, Tatsuro Irimura and Yoshihiro Hayakawa
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 5 Pages: 558-562

    • DOI

      10.1111/cas.12112

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs.2013

    • Author(s)
      Jeong D, Watari K, Shirouzu T, Ono M, Koizumi K, Saiki I, Kim YC, Tanaka C, Higuchi R, Miyamoto T.
    • Journal Title

      Biol Pharm Bull

      Volume: 36 Pages: 152-157

    • NAID

      130003361357

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model.2013

    • Author(s)
      Ji-Ye Kee et al.
    • Journal Title

      Oncology Reports

      Volume: 29(3) Issue: 3 Pages: 975-982

    • DOI

      10.3892/or.2012.2185

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas.2013

    • Author(s)
      Xue R, Han N, Sakurai H, Saiki I, Ye C, Yin J.
    • Journal Title

      Planta Med

      Volume: 79 Issue: 02 Pages: 157-162

    • DOI

      10.1055/s-0032-1328021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein.2012

    • Author(s)
      Waiwut P, Shin MS, Yokoyama S, Saiki I, Sakurai H.
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 1997-2003

    • NAID

      130001872260

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uvaridacols E-H, Highly Oxygenated Antiausterity Agents from Uvaria dac.2012

    • Author(s)
      Awale S, Ueda JY, Athikomkulchai S, Dibwe DF, Abdelhamed S, Yokoyama S, Saiki I, Miyatake R.
    • Journal Title

      J Nat Prod

      Volume: 75 Pages: 1999-2002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-austerity agents from Uvaria dac and their preferential cytotoxic activity against human pancreatic cancer cell lines in nutrient deprived condition.2012

    • Author(s)
      Awale S,Ueda J,Athikomkulchai S,Abdelhamed S,Yokoyama S,Saiki I,Miyatake R.
    • Journal Title

      J Nat Prod

      Volume: 75 Issue: 6 Pages: 1177-1183

    • DOI

      10.1021/np300295h

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations.2012

    • Author(s)
      Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao QL, Nomura T, Saiki I, Kondo T.
    • Journal Title

      Radiat Res

      Volume: 177 Pages: 766-774

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tobe K. SRT1720, a SIRT1 activator pomotes tumor cell migration, and lung metasiasis of breast cancer in mice2012

    • Author(s)
      Suzuki K
    • Journal Title

      Oncol Rep

      Volume: 27 Pages: 1726-1732

    • DOI

      10.3892/or.2012.1750

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation2012

    • Author(s)
      Prangsaengtong O
    • Journal Title

      Human Cell

      Volume: 25 Issue: 2 Pages: 36-44

    • DOI

      10.1007/s13577-012-0042-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.2012

    • Author(s)
      Igarashi Y, Iida T, Fukuda T, Miyanaga S, Sakurai H, Saiki I, Miyanouchi K.
    • Journal Title

      J Antibiot (Tokyo)

      Volume: 65 Issue: 4 Pages: 207-209

    • DOI

      10.1038/ja.2011.137

    • NAID

      10030641353

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] omisin N enhances TRAIL-induced apoptosis via reactive oxgen species-mediated up-regultion of death receptor 4 and 52012

    • Author(s)
      Inoue H
    • Journal Title

      omisin N enhances TRAIL-induced apoptosis via reactive oxgen species-mediated up-regultion of death receptor 4 and 5

      Volume: 40 Pages: 1058-1065

    • DOI

      10.3892/ijo.2011.1299

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 腫瘍増殖におけるNK細胞産生IFN-gの初期エフェクター機構としての重要性2014

    • Author(s)
      28) 小倉圭介、松下(佐藤)まりも、田原秀晃、早川芳弘
    • Organizer
      第43回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Metabolomic analysis of bioactive constituents produced by fermentation of brown rice.2014

    • Author(s)
      29) Tanaka K., Horie Y., Nemoto H., Kosaka H., Doumi S. and Saiki I.
    • Organizer
      Joint Symposium of the 3rd International Symposium on Rice and Disease prevention Pre-symposium of 9th Asia Pacific Conference on Clinical Nutrition.
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of Keishibukuryogan on genetic and diet-induced obesity models.2014

    • Author(s)
      Gao F., Yokoyama S., Fujimoto M., Shimada Y., Saiki I. and Hayakawa Y.
    • Organizer
      17th International Conference of Oriental Medicine
    • Place of Presentation
      Taiwan
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Secretory CTGF mediates autonomous MET-like alterations in mesenchymal-transitioned A549 cells.2014

    • Author(s)
      Kato S., Yokoyama S., Hayakawa Y. and Saiki I.
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Piperine enhances the efficacy of trail-based therapy for triple-negative breast cancer cells.2014

    • Author(s)
      Abdelhamed S., Yokoyama S., Refaat A., Ogura K., Awale S. and Saiki I.
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] メラノーマの転移抑制を目指したSLUGに対する脱ユビキチン化酵素の探索2014

    • Author(s)
      岩上雄亮、横山 悟、兼頭直希、加藤真一郎、早川芳弘、済木育夫
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腫瘍増殖におけるNK細胞産生IFN-gの初期エフェクター機構としての重要性2014

    • Author(s)
      小倉圭介、松下(佐藤)まりも、田原秀晃、済木育夫、早川芳弘
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF&#61485;kB activation.2014

    • Author(s)
      Lou C., Takahashi K., Irimura T., Saiki I. and Hayakawa Y.
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腎がん・肺がんの転移抑制活性を有する生薬の探索とその機序解析2014

    • Author(s)
      横山 悟、金 諒英、村田 純、岩下 淳、加藤真一郎、兼頭直希、櫻井宏明、李 峰、田中 謙、早川芳弘、済木育夫
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Curcumin and cancer metastasis2014

    • Author(s)
      Saiki I.
    • Organizer
      ICP2014 Nagoya XXVIIth International Conference on Polyphenols (ICP2014 Nagoya) and The 8th Tannin Conference
    • Place of Presentation
      名古屋
    • Year and Date
      2014-09-02 – 2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 漢方シグナルパネルの構築とその応用2014

    • Author(s)
      江島 静、横山 悟、早川芳弘、阿部貴志、済木育夫
    • Organizer
      第31回和漢医薬学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Sensitization for anti-cancer drug by Saikosaponin B22014

    • Author(s)
      Ma H., Yokoyama S., Saiki I. and Hayakawa Y.
    • Organizer
      第31回和漢医薬学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of novel anti-inflammatory compounds from Morus alba Linne by targeting NF-&#61547;B2014

    • Author(s)
      Hardianti B., Li F., Yokoyama S., Saiki I. and Hayakawa Y.
    • Organizer
      第31回和漢医薬学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vd1 T細胞を起点とする自然炎症はがん悪性化を促進する2014

    • Author(s)
      早川芳弘、木村好孝、永井 直、松下(佐藤)まりも、田原秀晃、善本隆之、済木育夫、入村達郎
    • Organizer
      第18回日本がん免疫学会
    • Place of Presentation
      松山
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内シグナルからみる天然薬物2014

    • Author(s)
      横山 悟、江島 静、阿部貴志、済木育夫
    • Organizer
      天然薬物研究方法論アカデミー 第17回富山シンポジウム ―天然薬物からの創薬―
    • Place of Presentation
      富山
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vd1 T細胞を起点とする自然炎症はがん悪性化を促進する2014

    • Author(s)
      早川芳弘、済木育夫、入村達郎
    • Organizer
      第23回日本がん転移学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生体内凍結技法によるマウス癌初期転移肺組織内微小血行動態のバイオイメージング2014

    • Author(s)
      齊藤百合花、寺田信生、大野伸彦、済木育夫、大野伸一
    • Organizer
      第23回日本がん転移学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肺がんにおけるSNAILに対する脱ユビキチン化酵素の探索2014

    • Author(s)
      横山 悟、兼頭直希、加藤真一郎、早川芳弘、済木育夫
    • Organizer
      第23回日本がん転移学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] TRAIL/DR5を介した炎症性シグナルのがん転移における役割2014

    • Author(s)
      高橋恵生、竹田和由、済木育夫、入村達郎、早川芳弘
    • Organizer
      第23回日本がん転移学会
    • Place of Presentation
      金沢
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] エビデンスによる効果の客観化 ~漢方薬とがん治療~2014

    • Author(s)
      済木育夫
    • Organizer
      第65回日本東洋医学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-27 – 2014-06-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] TRAIL/DR5を介した炎症性シグナルのがん病変における役割2014

    • Author(s)
      高橋恵生、済木育夫、入村達郎、早川芳弘
    • Organizer
      第18回日本がん分子標的治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] NF-kB経路をターゲットした天然物由来乳がん転移抑制化合物の探索2014

    • Author(s)
      早川芳弘、高橋恵生、入村達郎、済木育夫
    • Organizer
      第18回日本がん分子標的治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん治療薬開発のソースとしての漢方薬 ~漢方薬とがん転移~2014

    • Author(s)
      済木育夫
    • Organizer
      文部省新学術領域研究・がん支援「化学療法基盤支援活動」 第3回シンポジウム:アカデミアからの抗がん剤創薬に向けて 天然物の有効利用
    • Place of Presentation
      沖縄
    • Year and Date
      2014-05-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] survivinの抑制がレスベラトロールによる悪性黒色腫のアポトーシスに必須である2014

    • Author(s)
      横山 悟、Habibie、Abdelhamed Sherif、Awale Suresh、櫻井 宏明、早川 弘、済木育夫
    • Organizer
      文部省新学術領域研究・がん支援「化学療法基盤支援活動」 第3回シンポジウム:アカデミアからの抗がん剤創薬に向けて 天然物の有効利用
    • Place of Presentation
      沖縄
    • Year and Date
      2014-05-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Helicobacter pylori induces phosphrylation of epidermal growth factor receptor via p38/ERK activation in gastric epithelial cells in heparin binding-epidermal growth factor independent manner.2013

    • Author(s)
      Faisal S. Z., Refaat A., Saiki I. Sakurai I. and Sugiyama T.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando/USA
    • Related Report
      2013 Research-status Report
  • [Presentation] イメージングによるマウス4T1細胞の腫瘍微小環境における転写因子NF-&#61547;Bを介した炎症性シグナル活性化の時空間的解析2013

    • Author(s)
      高橋恵生、永井 直、済木育夫、入村達郎、早川芳弘
    • Organizer
      第17回日本がん分子標的治療学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 4T1乳がんモデルにおける炎症性腫瘍微小環境形成におけるCD4+ T細胞の重要性2013

    • Author(s)
      早川芳弘、髙橋恵生、永井直、済木育夫、入村達郎
    • Organizer
      第17回日本がん免疫学会総会
    • Place of Presentation
      宇部
    • Related Report
      2013 Research-status Report
  • [Presentation] がん微少環境におけるケモカインCXCL16の二面性、 ー がん免疫監視分子とがん細胞シグナル分子としての役割 ー2013

    • Author(s)
      小泉桂一、奇 知芸、櫻井宏明、入村達郎、済木育夫
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス4T1乳がんモデルでの炎症性腫瘍微小環境形成におけるCD4陽性T細胞の重要性2013

    • Author(s)
      高橋恵生、永井 直、済木育夫、入村達郎、早川芳弘
    • Organizer
      第22回日本がん転移学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Research-status Report
  • [Presentation] Berberine and Cancer metastasis2013

    • Author(s)
      Saiki I.
    • Organizer
      International Seminar on Natural Product Discoveries and Its Impact on Pharmaceutical Sciences
    • Place of Presentation
      Surabaya
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 桂皮由来のProcyanidin C1によるTGF-beta依存性上皮間葉転換を抑制する機能解析2013

    • Author(s)
      金 諒英、加藤真一郎、兼頭直希、櫻井宏明、早川芳弘、李 峰、田中 謙、済木育夫、横山 悟
    • Organizer
      第30回和漢医薬学会総会
    • Place of Presentation
      金沢
    • Related Report
      2013 Research-status Report
  • [Presentation] Enhancing effect of Thevetia peruviana flower extract on trail induced apoptosis in human cervical cancer cells.2013

    • Author(s)
      Managit C., Sakurai H., and Saiki I.
    • Organizer
      The 61st International Congress And Annual Meeting Of The Society For Medicinal Plant And Natural Product Research.
    • Place of Presentation
      Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] 玄米酵素による機能性成分の生成に関する研究2013

    • Author(s)
      堀江裕紀子、田中 謙、根本英幸、小坂弘明、小林 博、済木育夫
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道
    • Related Report
      2013 Research-status Report
  • [Presentation] Resveratrol induces apoptosis in melanoma cells via downregulation of survivin expression.2013

    • Author(s)
      Habibie, Abdelhamed S., Awale S., Hayakawa Y., Saiki I. and Yokoyama S.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] RAC1 inhibitor suppresses gefitinib-resistant NSCLC cell migration.2013

    • Author(s)
      Kaneto N., Kato S., Yokoyama S. and Saiki I.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Mesenchymal-transitioned cancer cells instigate surrounding cancer cells to metastasis via secretion of WNT ligands.2013

    • Author(s)
      Kato S., Yokoyama S., Hayakawa Y. and Saiki I.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Identification of plant extracts sensitizing breast cancer cells to TRAIL.2013

    • Author(s)
      Abdelhamed S., Yokoyama S., Lia Hafiyani, Kalauni S.K., Hayakawa Y., Awale S. and Saiki I.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Cross-talk between host and cancer cells amplify inflammation triggered by gdT17 cells to promote malignant progression.2013

    • Author(s)
      Kimura Y., Sato-Matsushita M., Yoshimoto T., Tahara H., Saiki I., Irimura T. and Hayakawa Y.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Role of inflammatory microenvironment for acquiring malignant phenotypes in QR32 fibrosarcoma model.2013

    • Author(s)
      Nagai N., Saiki I., Irimura T. and Hayakawa Y.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Requirement of CD4+ T cells for establishing inflammatory tumor microenvironment in 4T1 breast cancer model.2013

    • Author(s)
      Takahashi K., Nagai N., Tsuneyama K., Saiki I., Irimura T. and Hayakawa Y.
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Resveratrol induces apoptosis in melanoma cells via downregulation of survivin expression.2013

    • Author(s)
      Saiki I., Habibie, Abdelhamed S., Awale S., Hayakawa Y. and Yokoyama S.
    • Organizer
      8th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine
    • Place of Presentation
      Greece
    • Related Report
      2013 Research-status Report
  • [Presentation] Curucumin and cancer metastasis2013

    • Author(s)
      Saiki I.
    • Organizer
      Hamdard International Unani Medicine Conference-2013
    • Place of Presentation
      Pakistan
    • Related Report
      2012 Research-status Report
  • [Presentation] Resveratrol induces apoptosis in melanoma cells via downregulation of survivin expression2013

    • Author(s)
      Habibie, Yokoyama S., Abdelhamed S., Awale S., Hayakawa Y. and Saiki I.
    • Organizer
      Second Makassar International Symposium on Pharmaceutical Science
    • Place of Presentation
      Indonesia
    • Related Report
      2012 Research-status Report
  • [Presentation] Thr-669リン酸化によるEGFRチロシンキナーゼのフィードバック阻害機構2012

    • Author(s)
      櫻井宏明,済木育夫
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report
  • [Presentation] TAK1キナーゼを標的としたがん治療法の確立に向けて,シンポジウム2「転移機構を標的とした治療展開」2012

    • Author(s)
      櫻井宏明,済木育夫
    • Organizer
      第21回日本がん転移学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 不均一ながん細胞間の相互作用がEMT/METを制御する2012

    • Author(s)
      加藤真一郎,横山悟,済木育夫
    • Organizer
      第21回日本がん転移学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] ゲフィチニブによる肺がん転移抑制機構の解析2012

    • Author(s)
      兼頭直希,加藤真一郎,横山悟,済木育夫
    • Organizer
      第21回日本がん転移学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] IRF-8を介したTNF-&#61537;誘導生のアポトーシスによるCXCL16高発現大腸がんの肝転移抑制2012

    • Author(s)
      Kee J-Y.,伊東彩,櫻井宏明,入村達郎,済木育夫,小泉桂一
    • Organizer
      第21回日本がん転移学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-17-producing NK1.1– CD27– gdT cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      Hayakawa Y., Kimura Y., Tsunekawa N., Sato-Matsushita M., Tahara H., Saiki I., and Irimura T.
    • Organizer
      第16回日本がん免疫学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Hevetia peruviana enhances TNF-&#61537; induced apoptosis in human cervical cancer cells2012

    • Author(s)
      Managit C., Samee W., Sakurai H., and Saiki I.
    • Organizer
      International Congress on Natural Products Research
    • Place of Presentation
      New York, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] シンポジウム1「和漢医薬学とがん」漢方薬によるがん転移の抑制とその機序2012

    • Author(s)
      済木育夫
    • Organizer
      第29回和漢医薬学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 上皮間葉転換を抑制する桂皮の機能解析2012

    • Author(s)
      金諒英,加藤真一郎,兼頭直希,櫻井宏明,早川芳弘,李峰,田中謙,横山悟,済木育夫
    • Organizer
      第29回和漢医薬学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Mesenchymal-transitioned Epithelial cancer cells instigate EMT via pancreatic WNT signals.2012

    • Author(s)
      Kato S., Yokoyama S., Hayakawa Y., and Saiki I.
    • Organizer
      14th International Biennial Congress of the Metastasis Research Society
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Research-status Report
  • [Presentation] Gomisin N Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)- Induced Apoptosis2012

    • Author(s)
      Inoue H., Sakurai H., Nogami N., Fujimoto M., Hikiami H., Shibahara N., Saiki I., and Shimada Y.
    • Organizer
      16th International Congress of Oriental Medicine (ICOM)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Berberine-induced sensitization of metastatic breast cancer to TRAIL treatment2012

    • Author(s)
      Refaat A., Diaa S., Yagita H., Yokoyama S., Hayakawa Y. and Saiki I.
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] リガンド濃度に依存したEGF受容体の多次元的リン酸化制御2012

    • Author(s)
      田中智大,周越,申明淑,河崎優希,佐久間勉,済木育夫,櫻井宏明
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 間葉転換した上皮系がん細胞に付与されるパラクラインWNTシグナルはEMTの更なる助長を導く2012

    • Author(s)
      加藤真一郎,横山悟,早川芳弘,済木育夫
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] :IL-17-producing NK1.1–CD27– gdT cells promote tumor malignant progression by inducing inflammatory microenvironment2012

    • Author(s)
      早川芳弘,佐藤(松下)まりも,田原秀晃,済木育夫,入村達郎
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Bioluminescent imaging of inflammatory tissue microenvironment in 4T1 breast cancer model2012

    • Author(s)
      高橋恵生,入村達郎,早川芳弘
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Curucumin and cancer metastasis2012

    • Author(s)
      Saiki I.
    • Organizer
      International Symposium: Medicinal Plant and Natural Product Research Traditional and Modern Aspects
    • Place of Presentation
      Ulaanbaatar, Mongolia.
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Curucumin and cancer metastasis2012

    • Author(s)
      Saiki I.
    • Organizer
      Joint seminar on “Recent Advances in Natural Products and Biotechnology”
    • Place of Presentation
      Cairo, Egypt
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Proteomic identification of biomarkers for diagnosis and treatment of traditional Japanese (Kampo) medicine2012

    • Author(s)
      Saiki I.
    • Organizer
      The 4th Conference on Traditional Medicine in ASEAN countries 2Towards Harmonisation of Traditional Medicine Practices”
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 漢方薬とがん転移,特別企画2「がんの統合医療」2012

    • Author(s)
      済木育夫
    • Organizer
      第16回日本統合医療学会(IMJ大阪大会)
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 「がん漢方」2012

    • Author(s)
      済木育夫
    • Total Pages
      12
    • Publisher
      南山堂
    • Related Report
      2012 Research-status Report
  • [Remarks] 富山大学 和漢研 病態生科学分野 研究業績

    • URL

      http://www.inm.u-toyama.ac.jp/pb/gyoseki/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 富山大学 和漢研 病態生化学分野 研究業績

    • URL

      http://www.inm.u-toyama.ac.jp/pb/gyoseki/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 富山大学 和漢研・病態生化学 研究業績

    • URL

      http://www.inm.u-toyama.ac.jp/pb/gyoseki/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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