Modification of diabetic phenotype by Alzheimer's disease
| Project/Area Number |
24659349
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
SATO Naoyuki 大阪大学, 医学(系)研究科(研究院), 准教授 (70372612)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 糖尿病 / アルツハイマー病 / βアミロイド / 認知症 / 脳科学 / 分子生物学 / ベータ・アミロイド / 相互病態修飾 / 糖代謝 |
|---|
| Research Abstract |
We previously showed that Alzheimer's disease (AD) aggravates the diabetic phenotype in mice. To explore this mechanism, we initiated to create APP Tet-off mice. Plasma Abeta may mediate peripheral insulin resistance. We found plasma Abeta level is increased after glucose loading in an AD model. In humans, although the magnitude of changes is much smaller than in AD transgenic mice, the changes in plasma Abeta levels after oral glucose loading are different between AD and non-AD patients. These data suggest that one of the possible mechanisms by which AD aggravates the diabetic phenotype might be attributable to plasma Abeta. We are now constructing APP Tet-off plasmid and will create APP tet-off mice to control the periods of APP expression and exposure to diabetes.
|
Report
(3 results)
Research Products
(51 results)
-
-
-
-
-
-
-
-
[Journal Article] HIG1, a novel regulator of mitochondrial y-secretase, maintains normal mitochondrial function2012
Author(s)
Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y. HIG1
-
Journal Title
FASEB J J
Volume: 26(6)
Pages: 2306-17
DOI
Related Report
-
-
-
-
-
-
[Presentation] Possible involvements of Abeta, insulin signaling and tau phosphorylation in the pathological interaction between Alzheimer disease and diabetes2013
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
AAIC 2013 The Alzheimer's Association International Conference 2013
Place of Presentation
Boston
Year and Date
2013-07-14
Related Report
-
-
-
-
-
-
-
-
-
[Presentation] Diabetes increases tau phosphorylation in APP mice : evidence that Abeta is prerequisite, but insufficient to cause tau phosphorylation2013
Author(s)
N Sato, M Mori-Ueda, T Tanaka, S Takeda, K Uchio-Yamada, H Ueda, M Shinohara, S Murayama, M Takeda, H Rakugi, R Morishita
Organizer
The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
Place of Presentation
Italy
Year and Date
2013-03-10
Related Report
-
[Presentation] Amyloid precursor protein/presenilin 1 interaction is differentially regulated during Abeta40/42 production : detection using fusion constructs2013
Author(s)
N Sato, M Okochi, M Shinohara, G Thinakaran, S Takeda, A Fukumori, M Shinohara-Noma, M Mori-Ueda, H Hamada, M Takeda, H Rakugi, R Morishita
Organizer
The 11th International Conference on Alzheimer's & Parkinson's Diseases AD/PD 2013
Place of Presentation
Italy
Year and Date
2013-03-09
Related Report
-
-
-
[Presentation] Tau phosphorylation is ncreased by diabetes mellitus in APP transgenic mice2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
The 17th Takeda Science Foundation Symposium on Bioscience
Place of Presentation
Osaka
Year and Date
2012-12-07
Related Report
-
[Presentation] Amyloid Precursor Protein/Presenilin 1 Interaction is Differentially Regulated during A1340/42 Production : Detection Using Fusion Constructs2012
Author(s)
Naoyuki Sato, Masayasu Okochi, Mitsuru Shinohara, Gopal Thinakaran, Shuko Takeda, Akio Fukumori, Motoko Shinohara-Noma, Mari Mori-Ueda, Hizuki Hamada, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
The 17th Takeda Science Foundation Symposium on Bioscience
Place of Presentation
Osaka
Year and Date
2012-12-07
Related Report
-
-
-
[Presentation] The mechanisms by which diabetes mellitus increases the risk of Alzheimer's disease2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Keystone Symposia, Aging and Diseases of Aging
Place of Presentation
Tokyo
Year and Date
2012-10-25
Related Report
-
[Presentation] Old APPxob/ob mice showed highly increased level of tau phosphorylation in brain2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Neuroscience 2012
Place of Presentation
New Orleans
Year and Date
2012-10-15
Related Report
-
[Presentation] The mechanism by which diabetes mellitus increase the risk of Alzheimer disease2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Neuroscience2012
Place of Presentation
Nagoya
Year and Date
2012-09-18
Related Report
-
-
-
[Presentation] Roles of beta-amyloid and insulin resistance in the interaction between diabetes mellitus and Alzheimer's disease2012
Author(s)
Naoyuki Sato, Mari Mori-Ueda, Toshihisa Tanaka, Shuko Takeda, Kozue Uchio-Yamada, Hironori Ueda, Mitsuru Shinohara, Shigeo Murayama, Masatoshi Takeda, Hiromi Rakugi, Ryuichi Morishita
Organizer
Gordon Research Conferences, Neurobiology of Brain Disorders. Chair: Jie Shen, Vice Chair: Joachim J. Herz
Place of Presentation
Stonehill College
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
