Calorie restriction associated microRNA: Possibility of biomarkers of human aging-dependent diseases
Project/Area Number |
24659351
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
General internal medicine (including Psychosomatic medicine)
|
Research Institution | Nagasaki University |
Principal Investigator |
SHIMOKAWA Isao 長崎大学, 医歯(薬)学総合研究科, 教授 (70187475)
|
Co-Investigator(Kenkyū-buntansha) |
MAEDA Takahiro 長崎大学, 大学院医歯薬学総合研究科, 教授 (40284674)
|
Co-Investigator(Renkei-kenkyūsha) |
MORI Ryoichi 長崎大学, 大学院医歯薬学総合研究科, 講師 (30509310)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 老年医学 / microRNA / バイオマーカー / Mi-RNA / 代謝疾患 / 生活習慣病 / カロリー制限 / 老化 / マイクロRNA |
Research Abstract |
MicroRNAs (miRNAs) belong to a small, non-coding RNA family and regulate the translational process of target messenger RNAs (mRNAs). It is reported that miRNAs circulate throughout a body (as circulating miRNA, c-miRNA), and that some c-miRNA expressions are altered with the physiological condition. We investigated the function of c-miRNAs in human blood plasma and their application as a biomarker. We identified the c-miRNAs associated with hypertension and obesity by using quantitative PCR, which suggested that c-miRNAs might regulate the metabolic state among distant organs. Thus, the identification of c-miRNAs in blood plasma has a high potential use both for diagnosis and for establishing a therapeutic target among lifestyle-related diseases.
|
Report
(3 results)
Research Products
(40 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Hyperadipo-nectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation2012
Author(s)
Otabe S, Wada N, Hashinaga T, Yuan X, Shimokawa I, FukutaniT, Tanaka K, Ohki T, Kakino S, Kurita Y, Nakayama H, Tajiri Y, Yamada K
-
Journal Title
Journal of Endocrinology
Volume: 213
Issue: 1
Pages: 67-76
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012
Author(s)
Shimokawa I, Chiba T, Park S, Komatsu T, Chung H, Mori R, Kusudo T, Yamashita H, Park D
Organizer
2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint meeting
Place of Presentation
Osong, Korea
Related Report
Invited
-
-
-
-