Analysis and therapeutic application of the neuroimmune system in the neurodegenerative disease models
Project/Area Number |
24659352
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | アルツハイマー病 / アミロイドβ / トランスジェニック / ミクログリア |
Outline of Final Research Achievements |
In the present study, we analyzed the change of neuroimmune system (e.g. microglia) as the reaction to the neurodegeneration to elucidate the neuroprotective effect of that and apply the result to new therapeutic strategy. We observed accumulation of CD68 (which is phagocytic marker) positive activated microglia at Aβ deposition sites in the brain of an intra-hippocampal Aβ-injected mouse model of AD. Those phagocytosed Aβ deposition early after Aβ injection. By contrast, we observed the gradual increase of activated microglia accumulation at Aβ deposition sites in the brain of AD transgenic model mice (APdE9 mice). In the early stage of AD-like pathology, alpha 7 nicotinic acetylcholine receptor (α7nAChR) in microglia was upregulated. On the other hand, CD68 was significantly increased in the late stage of AD-like pathology.
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Report
(5 results)
Research Products
(8 results)
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[Presentation] Temporal changes of microglial activation and alpha7 nAChR in APdE9 mice.2015
Author(s)
松村晃寛, 鈴木紘美, 山内綾乃, 岩原直敏, 松下隆司, 鈴木秀一郎, 久原 真, 川又 純, 高田和幸, 北村佳久, 下濱 俊
Organizer
第56回日本神経学会学術大会
Place of Presentation
新潟コンベンションセンター( 朱鷺メッセ)( 新潟県新潟市)
Year and Date
2015-05-20
Related Report
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[Presentation] アルツハイマー病トランスジェニックマウスモデルにおける脳内グリア細胞の動態解析2013
Author(s)
松村晃寛,鈴木紘美,大橋乃理子,岩原直敏,鈴木秀一郎,津田笑子,林 貴士,齊藤正樹,久原 真,川又 純,今井富裕,下濱 俊,佐々木祐典,本望 修,三國信啓,高田和幸,北村佳久
Organizer
第54回日本神経学会学術大会
Place of Presentation
東京
Related Report
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[Presentation] 脳内アミロイドβに対する脳内グリア細胞の動態解析2012
Author(s)
松村晃寛, 鈴木紘美, 鈴木秀一郎, 山内理香, 林 貴士, 齊藤正樹, 久原 真, 川又 純, 今井富裕, 下濱 俊, 本望 修, 高田和幸, 北村佳久
Organizer
第53回日本神経学会学術大会
Place of Presentation
東京
Related Report