| Project/Area Number |
24659356
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SHIMOUCHI Akito 独立行政法人国立循環器病研究センター, 研究所, 室長 (80211291)
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| Co-Investigator(Kenkyū-buntansha) |
SATA Makoto 国立循環器病研究センター, 病院, 医長 (00280892)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Takaharu 中部大学, 生命健康科学部, 教授 (20135388)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 呼気水素 / 呼気成分 / 食物繊維 / 難消化性多糖類 / 代替医療 / 抗酸化作用 / 水素分子 / 呼気低分子化合物 / 酸化ストレス / 腸内嫌気性発酵 / 嫌気性発酵 |
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| Outline of Final Research Achievements |
Human body possesses H2-producing process via colonic fermentation. Ingestion of milk causes a marked and sustained rise in breath H2. Breath H2 levels after milk ingestion had a significantly positive correlation to the venous Biological Anti-oxidant Potential. Milk and dairy decrease the risks of mortality from cerebrovascular disease or stroke. It is also reported that preventive effect of arcabose on cardiovascular events in diabetic patients might be attributed to H2 increase in the body. Breath H2 significantly decreases depending upon ages. Thus, we propose a hypothesis that molecular H2 production by colonic fermentation may play a role of "endogenous" antioxidant weakly but for long-term periods of life. In the present study, we examined effects of various foods containing plenty of unabsorbable fibers on exhaled breath in adult humans.
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