Identification of novel transporter for exporting iron to establish effective therapy for chronic liver disorder

Research Project

Project/Area Number	24659358
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Gastroenterology
Research Institution	University of Tsukuba
Principal Investigator	MIZOKAMI Yuji 筑波大学, 医学医療系, 准教授 (70268556)
Co-Investigator(Kenkyū-buntansha)	蕨栄治筑波大学, 医学医療系, 講師 (70396612) 正田純一筑波大学, 医学医療系, 教授 (90241827)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	肝臓学 / 鉄代謝 / トランスポーター
Research Abstract	As excess iron accumulation in body cause oxidative stress, it is needed that effective iron excretion system. Surprisingly, there is only one molecule named FPN1 has been identified in this system. In this study, we aimed to identify novel iron exporting protein by focusing on the genes that expressions are regulated by Nrf2 having central role for anti-oxidative stress gene induction. By using microarray analysis, some candidates such as SLC40A1, HFE, FECH, CYBRD1, ISCU, SLC25A37 and TFRC were listed up, however, all of those did not have iron exporting activity.

Report

(3 results)