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Identification of novel transporter for exporting iron to establish effective therapy for chronic liver disorder

Research Project

Project/Area Number 24659358
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionUniversity of Tsukuba

Principal Investigator

MIZOKAMI Yuji  筑波大学, 医学医療系, 准教授 (70268556)

Co-Investigator(Kenkyū-buntansha) 蕨 栄治  筑波大学, 医学医療系, 講師 (70396612)
正田 純一  筑波大学, 医学医療系, 教授 (90241827)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝臓学 / 鉄代謝 / トランスポーター
Research Abstract

As excess iron accumulation in body cause oxidative stress, it is needed that effective iron excretion system. Surprisingly, there is only one molecule named FPN1 has been identified in this system. In this study, we aimed to identify novel iron exporting protein by focusing on the genes that expressions are regulated by Nrf2 having central role for anti-oxidative stress gene induction. By using microarray analysis, some candidates such as SLC40A1, HFE, FECH, CYBRD1, ISCU, SLC25A37 and TFRC were listed up, however, all of those did not have iron exporting activity.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2014 2013

All Presentation (2 results)

  • [Presentation] Obesity in p62-KO mice is prevented by estradiol2014

    • Author(s)
      Eiji Warabi, Kentaro Akiyama, Junichi Shoda and Tetsuro Ishii
    • Organizer
      The Environmental Response
    • Place of Presentation
      Sendai
    • Year and Date
      2014-02-28
    • Related Report
      2013 Final Research Report
  • [Presentation] p62/Sqstm1欠損は中枢におけるレプチン抵抗性により過食を引き起こす2013

    • Author(s)
      蕨栄治、石井哲郎、正田純一
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      松本
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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