Analysis of a novel transcriptional repressor involved in energy metabolism and application for metabolic liver diseases

• Project/Area Number: 24659360
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: University of Fukui
• Principal Investigator: NEMOTO Tomoyuki 福井大学, 医学部, 助教 (20397277)
• Co-Investigator(Renkei-kenkyūsha): YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 糖代謝 / インスリンシグナル / 転写因子 / Id2

Outline of Final Research Achievements

A dominant-negative transcriptional repressor, Id2 has been shown to regulate cell differentiation and proliferation. Id2 knockout mice have lean phenotype. Id2 deficiency conferred resistance to obesity and fatty liver development in a mouse model. Id2 knockout mice showed increased glucose tolerance and insulin sensitivity. Id2 was induced by insulin and mediated by phosphatidylinositol-3 kinase pathway. An increase of Id2 expression by insulin may be indispensable for adipocyte differentiation. Modulation of Id2 expression is thought to be a potential therapeutic target for fatty liver, metabolic syndrome, and furthermore, lifestyle-related diseases.

Research Products

• [Journal Article] Comparison of hepatic arterial infusion chemotherapy and sorafenib in elderly patients with advanced hepatocellular carcinoma: a case series (2014)
  • Author(s): Tomoyuki Nemoto, Hidetaka Matsuda, Takuto Nosaka, Yasushi Saito, Yoshihiko Ozaki, Ryoko Hayama, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Hiroyuki Suto, Yasunari Nakamoto
  • Journal Title: Molecular and Clinical Oncology Volume: 2 Issue: 6 Pages: 1028-1034
  • DOI: 10.3892/mco.2014.371
  • Peer Reviewed / Open Access
• [Presentation] Comparison of interferon-alpha combined with hepatic arterial infusion chemotherapy and sorafenib in patients with advanced hepatocellular carcinoma (2015)
  • Author(s): Tomoyuki Nemoto, Hidetaka Matsuda, Takuto Nosaka, Yasushi Saito, Yoshihiko Ozaki, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Hiroyuki Suto, Yasunari Nakamoto
  • Organizer: Keystone Symposia
  • Place of Presentation: Banff, Canada
  • Year and Date: 2015-02-11