| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
A dominant-negative transcriptional repressor, Id2 has been shown to regulate cell differentiation and proliferation. Id2 knockout mice have lean phenotype. Id2 deficiency conferred resistance to obesity and fatty liver development in a mouse model. Id2 knockout mice showed increased glucose tolerance and insulin sensitivity. Id2 was induced by insulin and mediated by phosphatidylinositol-3 kinase pathway. An increase of Id2 expression by insulin may be indispensable for adipocyte differentiation. Modulation of Id2 expression is thought to be a potential therapeutic target for fatty liver, metabolic syndrome, and furthermore, lifestyle-related diseases.
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