Research Project
Grant-in-Aid for Challenging Exploratory Research
In in vitro experiments, CagA significantly attenuated let-7 expression leading to Ras pathway activation. CagA enhanced c-myc, DNA methyltransferase 3B (DNMT3B) and Enhancer of Zeste homologue 2 (EZH2) expression and attenuated miR-26a and miR-101 expression, which resulted in the attenuation of let-7 expression by histone and DNA methylation. Experiments performed in CagA transgenic mice revealed that c-myc, EZH2 and DNMT3B expression were enhanced and let-7 expression was attenuated to induce Ras oncoprotein expression in the stomach, with no associated inflammation. It is concluded that H pylori CagA induces aberrant epigenetic silencing of let-7 expression, leading to Ras upregulation.
All 2014 2013 2012 Other
All Journal Article (27 results) (of which Peer Reviewed: 22 results) Presentation (8 results)
Dig Endosc.
Volume: 26 Issue: 2 Pages: 243-249
10.1111/den.12123
Gastrointest Endosc.
Volume: 79 Issue: 4 Pages: 679-680
10.1016/j.gie.2013.11.002
日本消化器病学会雑誌
Volume: 111 Pages: 521-528
130003392015
Digestion
Volume: 89 Issue: 2 Pages: 124-132
10.1159/000357229
Dis Esophagus
Volume: 26(Epub 2012 May 9.) Issue: 3 Pages: 343-344
10.1111/j.1442-2050.2012.01351.x
Endoscopy
Volume: 45 Issue: S 02 Pages: 135-135
10.1055/s-0032-1326450
World J Gastroenterol
Volume: 19 Issue: 9 Pages: 1485-1488
10.3748/wjg.v19.i9.1485
Inflamm Bowel Dis.
Volume: 19(2) Issue: 2 Pages: 321-31
10.1097/mib.0b013e318280eade
Gastroenterol Res Pract
Pages: 164530-164530
http://www.ncbi.nlm.nih.gov/pubmed/?term=endosonographic+assessment+of+yamamoto+s
GUT
Volume: 62 Issue: 11 Pages: 1536-1546
10.1136/gutjnl-2011-301625
Gut
Volume: 62 Issue: 10 Pages: 1425-1432
10.1136/gutjnl-2011-301647
Dis Esophagus. 2013 Apr : 26(3) : 349-50.
Volume: 26.(Epub 2012 Aug 7.) Issue: 3 Pages: 349-350
10.1111/j.1442-2050.2012.01387.x
Hepatol Res.
Volume: 43 Issue: 4 Pages: 339-346
10.1111/j.1872-034x.2012.01073.x
Endoscopy.
Volume: 45 Issue: S 02 Pages: 380-381
10.1055/s-0033-1344828
Gastroenterol Res Pract.
Volume: 2013 Pages: 365830-365830
10.1155/2013/365830
Volume: 87 Issue: 4 Pages: 269-80
10.1159/000349953
Volume: 110 Pages: 2127-2135
130003383333
Volume: 87 Issue: 2 Pages: 12-16
10.1159/000334678
Clin Calcium
Volume: 23 Pages: 243-248
Volume: 44(Epub 2012 May 23.) Issue: S 02 Pages: 222-223
10.1055/s-0032-1309353
Gastroenterology
Volume: 142(5) Issue: 5 Pages: 1172-82
10.1053/j.gastro.2012.02.008
Am J Physiol Gastrointest Liver Physiol.
Volume: 302(Epub 2012 Feb 9) Issue: 8 Pages: G773-G780
10.1152/ajpgi.00324.2011
IBD Journal
Volume: 18(9) Issue: 9 Pages: 1723-34
10.1002/ibd.22876
Volume: 2012 Pages: 194530-194530
日本臨床
Volume: 70 Pages: 869-873
40019297884
J Gastroenterol
Volume: (in press)
http://www.ncbi.nlm.nih.gov/pubmed/24356810
Inflamm Bowel Dis
http://www.ncbi.nlm.nih.gov/pubmed/24651581