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Analysis of unknown pathogen using human hepatocyte chimeric mouseand massive parallel sequencing

Research Project

Project/Area Number 24659368
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionHiroshima University

Principal Investigator

CHAYAMA Kazuaki  広島大学, 大学院・医歯薬保健学研究院, 教授 (00211376)

Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsウイルス、ゲノム / 細胞・組織 / 肝細胞キメラマウス / ウイルス / ゲノム / 肝細胞キメラマウス / 次世代シーケンサー
Research Abstract

We attempted to identify unknown pathogen from a patient with eruption and liver disorder with massive parallel sequencing. We found DNA sequences of cytomegalovirus from this patient. Further assembly of remaining non-human sequence is now going on.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (63 results)

All 2013 2012 2011 2010 Other

All Journal Article (36 results) (of which Peer Reviewed: 36 results) Presentation (7 results) Book (18 results) Remarks (2 results)

  • [Journal Article] Inhibition of hepatocellular carcinoma by PegIFNα2a in patients with chronic hepatitis C: a nationwide multi-center cooperative study.2013

    • Author(s)
      Izumi N, Asahina Y, Kumada H et al
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 3 Pages: 382-390

    • DOI

      10.1007/s00535-012-0641-9

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis2012

    • Author(s)
      Nagaoki Y, Aikata H, Kobayashi T, Fukuhara T, Masaki K, Tanaka M, et al
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 7 Pages: 847-55

    • DOI

      10.1007/s00535-012-0679-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetics of IL28B and HCV-response to infection and treatment2012

    • Author(s)
      Hayes CN
    • Journal Title

      Nat Rev Gastroenterol Hepato

      Volume: 9 Issue: 7 Pages: 406-17

    • DOI

      10.1038/nrgastro.2012.101

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.2012

    • Author(s)
      Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H
    • Journal Title

      Nature Genetic

      Volume: 44 Issue: 7 Pages: 760-764

    • DOI

      10.1038/ng.2291

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of rosuvastatin for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label2012

    • Author(s)
      Nakahara T, Hyogo H, Kimura Y, Ishitobi T, Arihiro K, Aikata H, et al
    • Journal Title

      pilot study. Hepatol Res

      Volume: 42 Issue: 11 Pages: 1065-1072

    • DOI

      10.1111/j.1872-034x.2012.01034.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication2012

    • Author(s)
      Chayama K
    • Journal Title

      Hepatol Res

      Volume: 42 Issue: 9 Pages: 841-53

    • DOI

      10.1111/j.1872-034x.2012.01002.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus2012

    • Author(s)
      Kobayashi M, Suzuki F, Akuta N, Sezaki H, Suzuki Y, Hosaka T, et al
    • Journal Title

      J Gastroenterol

      Volume: 47 Issue: 5 Pages: 596-605

    • DOI

      10.1007/s00535-012-0531-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL28B SNP of donors and recipients can predict virological response to PE GIFN/RBV therapy in patients with recurrent hepatitis C after living donor liver transplantation2012

    • Author(s)
      Kawaoka T, Takahashi S, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Aikata H, Ochi H, Onoe T, Tashiro H, Ohdan H, Chayama K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: (In press) Issue: 9 Pages: 1467-1472

    • DOI

      10.1111/j.1440-1746.2012.07129.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Follow up of the 987 blood donors found with hepatitis C virus infection over 9-18 years.2012

    • Author(s)
      Matsuo J, Mizui M, Okita H, Katayama K, Aimitsu S, Sakata T, Obayashi M, Nakanishi T, Chayama K, Miyakawa Y, Yoshizawa H, Tanaka J, ( Hiroshima Hepatitis Study Group)
    • Journal Title

      Hepatology Research

      Volume: 42 Issue: 7 Pages: 637-647

    • DOI

      10.1111/j.1872-034x.2012.00966.x

    • NAID

      10031144280

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients2012

    • Author(s)
      Ohnishi M, Tsuge M, Kohno T, Zhang Y, Abe H, Hyogo H, Kimura Y, Miki D, Hiraga N, Imamura M, Takahashi S, Ochi H, Hayes CN, Tanaka S, Arihiro K, Chayama K
    • Journal Title

      J Gastroenterol

      Volume: (in press) Issue: 7 Pages: 834-844

    • DOI

      10.1007/s00535-012-0550-y

    • NAID

      10030962375

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular carcinoma : towards personalized medicine2012

    • Author(s)
      Miki D, Ochi H, Nelson Hayes C, Aikata H, Chayama K
    • Journal Title

      Cancer Sci

      Volume: (in press) Issue: 5 Pages: 846-850

    • DOI

      10.1111/j.1349-7006.2012.02242.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe necroinflammatory reaction caused by natural killer by Fas/ FasL interaction and dendritic cells in human hepatocyte chimeric mouse2012

    • Author(s)
      Okazaki A, Hiraga N, Imamura M, NelsonHayes C, Tsuge M, Takahashi S, AikataH, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K
    • Journal Title

      Hepatology

      Volume: (in press) Issue: 2 Pages: 25651-25651

    • DOI

      10.1002/hep.25651

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study2012

    • Author(s)
      Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
    • Journal Title

      J Gastroenterol

      Volume: (in press) Issue: 5 Pages: 586-595

    • DOI

      10.1007/s00535-012-0533-z

    • NAID

      10030650741

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property2012

    • Author(s)
      Hyogo H, Yamagishi SI, Maeda S, Kimura Y, Ishitobi T, Chayama K
    • Journal Title

      Dig Liver Dis

      Volume: (in press) Issue: 6 Pages: 482-486

    • DOI

      10.1016/j.dld.2011.12.013

    • NAID

      120005308251

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum PAI-1 is a novel predictor for response to pegylated interferon-al pha-2b plus ribavirin therapy in chronic hepatitis C virus infection2012

    • Author(s)
      Miki D, Ohishi W, Ochi H, Hayes CN, Abe H, Tsuge M, Imamura M, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Viral Hepat

      Volume: 19 Issue: 2 Pages: 126-133

    • DOI

      10.1111/j.1365-2893.2011.01516.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis C2012

    • Author(s)
      Hayashi N, Okanoue T, Tsubouchi H, Toyota J, Chayama K, Kumada H
    • Journal Title

      J Viral Hepat

      Volume: 19 Issue: 2 Pages: 134-42

    • DOI

      10.1111/j.1365-2893.2011.01528.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor2012

    • Author(s)
      Sainz B, Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL
    • Journal Title

      Nat Med

      Volume: 18 Issue: 2 Pages: 281-285

    • DOI

      10.1038/nm.2581

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population2012

    • Author(s)
      Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T, Jsg-Nafld JS
    • Journal Title

      BMC Gastroenterol

      Volume: (Epub) Issue: 1 Pages: 2-2

    • DOI

      10.1186/1471-230x-12-2

    • NAID

      120005122663

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic arterial infusion chemotherapy using 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma in combination with or without three-dimensional conformal radiotherapy to venous tumor thrombosis in hepatic vein or inferior vena cava2012

    • Author(s)
      Murakami E, Aikata H, Miyaki D, Nagaoki Y, Katamura Y, Kawaoka T, et al
    • Journal Title

      Hepatol Res

      Volume: 42 Issue: 5 Pages: 442-453

    • DOI

      10.1111/j.1872-034x.2011.00943.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward the establishment of a prediction system for thepersonalized treatment of chronic hepatitis C2012

    • Author(s)
      Ochi H, Hayes CN, Abe H, Hayashida Y, Uchiyama T, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      J Infect Dis

      Volume: 205 Issue: 2 Pages: 204-210

    • DOI

      10.1093/infdis/jir726

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B2012

    • Author(s)
      Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, Hige S, Yatsuhashi H, Nagaoka S, Chayama K, Tsuge M, Yokosuka O, Imazeki F, Nishiguchi S, Saito M, Fujiwara K, Torii N, Hiramatsu N, Karino Y, Kumada H
    • Journal Title

      Hepatol Res

      Volume: 42 Issue: 2 Pages: 139-149

    • DOI

      10.1111/j.1872-034x.2011.00910.x

    • NAID

      10031144221

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, inhepatitis C virus genotype1b-infected null responders2012

    • Author(s)
      Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, KumadaH
    • Journal Title

      Hepatology

      Volume: 55 Issue: 3 Pages: 742-748

    • DOI

      10.1002/hep.24724

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 inJapan2012

    • Author(s)
      Kumada H, Toyota J, Okanoue T, ChayamaK, Tsubouchi H, Hayashi N
    • Journal Title

      J Hepatol

      Volume: 56 Issue: 1 Pages: 78-84

    • DOI

      10.1016/j.jhep.2011.07.016

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variati on Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy2012

    • Author(s)
      Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y, Kumada H
    • Journal Title

      Intervirology

      Volume: 55 Issue: 3 Pages: 231-41

    • DOI

      10.1159/000328327

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection2012

    • Author(s)
      Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Issue: 2 Pages: 418-425

    • DOI

      10.1245/s10434-011-1866-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual Oral Therapy with Daclatasvir and Asunaprevir for Patients with HCV Genotype 1b Infection and Limited Treatment Options2012

    • Author(s)
      Suzuki Y, Ikeda K, Suzuki F, Toyota J, Karino Y, Chayama K, et al
    • Journal Title

      J Hepatol

      Volume: 58 Issue: 4 Pages: 655-662

    • DOI

      10.1016/j.jhep.2012.09.037

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel HCV deletion mutants in chronic hepatitis C patients2012

    • Author(s)
      Kohno T, Tsuge M, Hayes CN, Hatakeyama T, Ohnishi M, Abe H, et al
    • Journal Title

      Antivir Ther

      Volume: 17 Issue: 8 Pages: 1551-1561

    • DOI

      10.3851/imp2265

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir2012

    • Author(s)
      Karino Y, Toyota J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, et al
    • Journal Title

      J Hepatol

      Volume: 58 Issue: 4 Pages: 648-645

    • DOI

      10.1016/j.jhep.2012.11.012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines2012

    • Author(s)
      Chayama K , Hayes CN, Ohishi W,Kawakami Y
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 1 Pages: 1-12

    • DOI

      10.1007/s00535-012-0714-9

    • NAID

      10031145523

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Follow up of the 987 blood donors found with hepatitis C virus infection over 9-18 years.2012

    • Author(s)
      Matsuo J
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 637-647

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.2012

    • Author(s)
      Urabe Y, Tanikawa C, Takahashi A, Okada Y, Morizono T, Tsunoda T, Kamatani N, Kohri K, Chayama K, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      PLoS Genet.

      Volume: 8 Issue: 3 Pages: 134-42

    • DOI

      10.1371/journal.pgen.1002541

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcomes of hepatic arterial port implantation using a coaxial microcatheter system in 176 patients with hepatocellular carcinoma2012

    • Author(s)
      Ishikawa M
    • Journal Title

      Hiroshima J Med Sci

      Volume: 61 Pages: 7-13

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of chronic hepatitis B with nuoleos(t)ide analogues2011

    • Author(s)
      Ohishi W, Chayama K
    • Journal Title

      Hepatol Ees

      Volume: 42 Issue: 3 Pages: 219-25

    • DOI

      10.1111/j.1872-034x.2011.00921.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent trend of clinical features in patients with hepatocellular carcinoma2011

    • Author(s)
      Nagaoki Y, Hyogo H, Aikata H, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Chayama K
    • Journal Title

      Hepatol Res (Epub 13 Dec.)

      Volume: (Epub) Issue: 4 Pages: 368-375

    • DOI

      10.1111/j.1872-034x.2011.00929.x

    • NAID

      10031144249

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Achievement of Sustained Viral Response after Switching Treatment from Pegylated Interferon alpha-2b to alpha-2a and Ribavirin in Patients with Recurrence of Hepatitis C Virus Genotype 1 Infection after Liver Transplantation : A Case Report2011

    • Author(s)
      Kawaoka T, Hiraga N, Takahashi S, Takaki S, Tsuge M, Nagaoki Y, Hashimoto Y, Katamura Y, Muki D, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Ochi H, Tashiro H, Ohdan H, Chayama K
    • Journal Title

      Intervirology (Elpub 25 Aug.)

      Volume: (Epub) Issue: 4 Pages: 306-310

    • DOI

      10.1159/000328661

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle2010

    • Author(s)
      Hayes CN, Akamatsu S, Tsuge M, Miki D, Akiyama R, Abe H, et al
    • Journal Title

      PLoS One

      Volume: 7 Issue: 10 Pages: e47490-e47490

    • DOI

      10.1371/journal.pone.0047490

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Successful Therapy with the NS5A Inhibitor Daclatasvir and NS3 Protease Inhibitor Asunaprevir in HCV Genotype 1B-infected Null Responders or Ineligible /Intolerant to PE

    • Author(s)
      茶山一彰
    • Organizer
      第98回日本消化器病学会総会 第3回国際交流フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] C型慢性肝炎~最新の治療~

    • Author(s)
      茶山一彰
    • Organizer
      日本消化器病学会中国支部 第15回教育講演会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Presentation] C型肝炎治療の最新の話題

    • Author(s)
      茶山一彰
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] C型肝炎に関する研究手法の進歩と臨床応用

    • Author(s)
      茶山一彰
    • Organizer
      第77回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Treatment of Chronic HCV Genotype 1B-Infected Patients with Peg-IFN/Ribavirin/Telaprevir Triple Therapy

    • Author(s)
      茶山一彰
    • Organizer
      第10回日本肝臓学会シングルトピックカンファレンス
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Successful Therapy with the NS5A Inhibitor and NS3 Protease Inhibitor to Chronic HCV Genotype 1B-Infected Patients

    • Author(s)
      茶山一彰
    • Organizer
      第10回日本肝臓学会シングルトピックカンファレンス
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウイルス肝炎 最近の話題

    • Author(s)
      茶山一彰
    • Organizer
      第98回日本消化器病学会中国支部例会
    • Place of Presentation
      宇部
    • Related Report
      2012 Annual Research Report
  • [Book] 特集非B非C型肝厳ー最新の知見わが国における非B非C型肝癌の実態(8)非B非C型k肝癌のリスクの因子2012

    • Author(s)
      茶山一彰
    • Total Pages
      6
    • Publisher
      日本メディカルセンター
    • Related Report
      2012 Final Research Report
  • [Book] 1.総論:ウイルス肝炎・肝癌に関する最新状況2012

    • Author(s)
      茶山一彰
    • Total Pages
      1
    • Publisher
      BIO Clinica
    • Related Report
      2012 Final Research Report
  • [Book] B 型肝炎に関する最近の話題2012

    • Author(s)
      茶山一彰
    • Total Pages
      4
    • Publisher
      広島市内科医会報
    • Related Report
      2012 Final Research Report
  • [Book] B 型肝炎に対する新薬開発の最新情報2012

    • Author(s)
      大石和佳
    • Total Pages
      5
    • Publisher
      医歯薬出版
    • Related Report
      2012 Final Research Report
  • [Book] [2]人体への影響[B]後障害 d.肝がん2012

    • Author(s)
      茶山一彰
    • Total Pages
      8
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 特集 C 型肝炎治療の最前線 5.テラプレビル耐性変異2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      本メディカルセンター
    • Related Report
      2012 Final Research Report
  • [Book] 特集 B 型肝炎治療:克服へのロードマップ2012

    • Author(s)
      大石和佳
    • Total Pages
      8
    • Publisher
      アークメディア
    • Related Report
      2012 Final Research Report
  • [Book] 核酸アナログ薬中止に伴うリスク回避のための指針20122012

    • Author(s)
      田中榮司
    • Total Pages
      6
    • Publisher
      肝臓
    • Related Report
      2012 Final Research Report
  • [Book] 特集消化器疾患の話題 B 型肝炎2012

    • Author(s)
      茶山一彰
    • Total Pages
      1
    • Publisher
      MEDICAMENT NEWS
    • Related Report
      2012 Final Research Report
  • [Book] 特集 非B非C型肝厳ー最新の知見わが国における非B非C型肝癌の実態 (8)非B非C型k肝癌のリスクの因子2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      日本メディカルセンター
    • Related Report
      2012 Annual Research Report
  • [Book] 1.総論:ウイルス肝炎・肝癌に関する最新状況2012

    • Author(s)
      茶山一彰
    • Total Pages
      2
    • Publisher
      BIO Clinica
    • Related Report
      2012 Annual Research Report
  • [Book] B型肝炎に関する最近の話題2012

    • Author(s)
      茶山一彰
    • Total Pages
      4
    • Publisher
      広島市内科医会報
    • Related Report
      2012 Annual Research Report
  • [Book] B型肝炎に対する新薬開発の最新情報2012

    • Author(s)
      大石和佳
    • Total Pages
      5
    • Publisher
      医歯薬出版
    • Related Report
      2012 Annual Research Report
  • [Book] [2]人体への影響 [B]後障害 d.肝がん2012

    • Author(s)
      茶山一彰
    • Total Pages
      8
    • Publisher
      文光堂
    • Related Report
      2012 Annual Research Report
  • [Book] 特集 C型肝炎治療の最前線 5.テラプレビル耐性変異2012

    • Author(s)
      茶山一彰
    • Total Pages
      7
    • Publisher
      日本メディカルセンター
    • Related Report
      2012 Annual Research Report
  • [Book] 特集 B型肝炎治療:克服へのロードマップ2012

    • Author(s)
      大石和佳
    • Total Pages
      8
    • Publisher
      アークメディア
    • Related Report
      2012 Annual Research Report
  • [Book] 核酸アナログ薬中止に伴うリスク回避のための指針20122012

    • Author(s)
      田中榮司
    • Total Pages
      6
    • Publisher
      The Japan Society of Hepatology
    • Related Report
      2012 Annual Research Report
  • [Book] 特集 消化器疾患の話題 B型肝炎2012

    • Author(s)
      茶山一彰
    • Total Pages
      2
    • Publisher
      MEDICAMENT NEWS
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/naika1/research_profile/liver_lab/

    • Related Report
      2012 Final Research Report
  • [Remarks] 広島大学病院消化器代謝内科ホームページ

    • URL

      http://home.hiroshima-u.ac.jp/naika1/research_profile/liver_lab/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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