| Project/Area Number |
24659369
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUJISAWA Koichi 山口大学, 医学(系)研究科(研究院), 助教 (00448284)
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| Co-Investigator(Kenkyū-buntansha) |
TERAI Shuji 山口大学, 大学院医学系研究科, 准教授 (00332809)
TAKAMI Taro 山口大学, 大学院医学系研究科, 講師 (60511251)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アデニル酸カイネース / ゼブラフィッシュ / 肝臓 |
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| Research Abstract |
We examined the analysis of energy metabolism of the ATP. Adenylate kinase isozyme expression was related to energy metabolism. In addition, an oxygen consumption rate changed by a knockdown of the adenylate kinase was evaluated by using the flux analyzer, and the change of the metabolic syndrome light included in TCA cycles such as the fumaric acid was recognized by the metabolome analysis, and importance of the adenylate kinase in the metabolism was shown.
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