The role of fibrocyte in intestinal fibrosis and screening of anti-fibrotic therapy targeting fibrocyte.

• Project/Area Number: 24659374
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: HIBI Toshifumi 慶應義塾大学, 医学部, 教授 (50129623)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: クローン病 / 腸管線維化 / fibrocyte

Research Abstract

We have found the increase of fibrocytes in peripheral blood of the patients with Crohn’s disease. We have investigated the risk factors of intestinal fibrosis in Crohn’s disease. Furthermore, we have started development of a novel mice model which reveal

Research Products

• [Journal Article] CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion (2013)
  • Author(s): Nakamura Y, Kanai T, Saeki K, Takabe M, Irie J, Miyoshi J, Mikami Y, Teratani T, Suzuki T, Miyata N, Hisamatsu T, Nakamoto N, Yamagishi Y, Higuchi H, Ebinuma H, Hozawa S, Saito H, Itoh H, Hibi T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol
  • Peer Reviewed
• [Journal Article] Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice (2013)
  • Author(s): Handa T, Kanai T, Sato T, Mikami Y, Sujino T, Hayashi A, Mizuno S, Matsumoto A, Hisamatsu T, Hibi T.
  • Journal Title: Immunol Lett.
  • Peer Reviewed
• [Journal Article] CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion. (2013)
  • Author(s): Nakamura Y, Kanai T, Saeki K, Takabe M, Irie J, Miyoshi J, Mikami Y, Teratani T, Suzuki T, Miyata N, Hisamatsu T, Nakamoto N, Yamagishi Y, Higuchi H, Ebinuma H, Hozawa S, Saito H, Itoh H, Hibi T.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 304 Issue: 8 Pages: G700-G707
  • DOI: 10.1152/ajpgi.00318.2012
  • Peer Reviewed
• [Journal Article] Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice. (2013)
  • Author(s): Handa T, Kanai T, Sato T, Mikami Y, Sujino T, Hayashi. A, Mizuno S, Matsumoto A, Hisamatsu T, Hibi T.
  • Journal Title: Immunology Letters Volume: 150 Issue: 1-2 Pages: 123-9
  • DOI: 10.1016/j.imlet.2013.01.010
  • Peer Reviewed
• [Journal Article] TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. (2013)
  • Author(s): Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T.
  • Journal Title: Immunology Volume: 139(1) Issue: 1 Pages: 19-29
  • DOI: 10.1111/imm.12045
  • Peer Reviewed
• [Journal Article] Immune aspects of the pathogenesis of inflammatory bowel disease (2012)
  • Author(s): Hisamatsu T, Kanai T, Yohei Mikami, Yoneno K, Matsuoka K, Hibi T
  • Journal Title: Pharmacol Ther.
  • Peer Reviewed
• [Journal Article] Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis (2012)
  • Author(s): Kimura K, Kanai T, Hayashi A, Mikami Y, Sujino T, Mizuno S, Handa T, Matsuoka K, Hisamatsu T, Sato T Hibi T
  • Journal Title: Biochem Biophys Res Commun Volume: 427 Pages: 694-700
  • Peer Reviewed
• [Journal Article] T-helper 17 and Interleukin-17-Producing Lymphoid Tissue Inducer-Like T Cells Make Different Contributions to Colitis in Mice (2012)
  • Author(s): Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T .
  • Journal Title: Gastroenterology. Volume: 143 Pages: 1288-97
  • Peer Reviewed
• [Journal Article] Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14+ macrophage activation (2012)
  • Author(s): Uo M, Hisamatsu T, Miyoshi J, Kaito D, Yoneno K, Kitazume MT, Mori M, Sugita A, Koganei K,Matsuoka K, Kanai T, Hibi T
  • Journal Title: Gut.
  • Peer Reviewed
• [Journal Article] Is the dendritic cell a missing piece in the pathogenesis model of post-infectious irritable bowel syndrome?-Editorial for "Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome. (2012)
  • Author(s): Hisamatsu T, Hibi T
  • Journal Title: J Gastroenterol Hepatol. Volume: 27 Pages: 847-8
  • Peer Reviewed
• [Journal Article] A Case of Intestinal Behcet's Disease Treated with Infliximab Monotherapy Who Successfully Maintained Clinical Remission and Complete Mucosal Healing for Six Years (2012)
  • Author(s): Maruyama Y, Hisamatsu T, Matsuoka K, Naganuma M, Inoue N, Ogata H, Iwao Y, Kanai T, Hibi T
  • Journal Title: Intern Med Volume: 51 Pages: 2125-9
  • Peer Reviewed
• [Journal Article] Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells. (2012)
  • Author(s): Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A.
  • Journal Title: J Exp Med. Volume: 209(13) Issue: 13 Pages: 2383-94
  • DOI: 10.1084/jem.20112631
  • Peer Reviewed
• [Journal Article] Anticoagulation therapy dramatically improved severe sigmoiditis with findings resembling inflammatory bowel disease, which was caused by mesenteric venous thrombosis. (2012)
  • Author(s): Mikami Y, Kanai T, Iwasaki E, Naganuma M, Yamagishi Y, Shimoda M, Matsuoka K, Hisamatsu T, Iwao Y, Ogata H, Nakatsuka S, Mukai M, Hibi T.
  • Journal Title: Clinical Journal of Gastroenterology. Volume: 5 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Immune aspects of the pathogenesis of inflammatory bowel disease. (2012)
  • Author(s): Hisamatsu T, Kanai T, Mikami Y, Yoneno K, Matsuoka K, Hibi T.
  • Journal Title: Pharmacology & Therapeutics Volume: 137 Issue: 3 Pages: 283-297
  • DOI: 10.1016/j.pharmthera.2012.10.008
  • Peer Reviewed
• [Journal Article] Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages. (2012)
  • Author(s): Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, and Hibi T.
  • Journal Title: Hepatology Research. Volume: Epub ahead of print Issue: 6 Pages: 658-669
  • DOI: 10.1111/j.1872-034x.2012.01111.x
  • NAID: 10031194568
  • Peer Reviewed
• [Journal Article] Dysregulated balance of retinoid-related orphan receptor _Yt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis. (2012)
  • Author(s): Kimura K, Kanai T, Hayashi A, Mikami Y, Sujino T, Mizuno S, Handa T, Matsuoka K, Hisamatsu T, Sato T, Hibi T.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 427 Issue: 4 Pages: 694-700
  • DOI: 10.1016/j.bbrc.2012.09.091
  • Peer Reviewed
• [Journal Article] Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14+ macrophage activation. (2012)
  • Author(s): Uo M, Hisamatsu T, Miyoshi J, Kaito D, Yoneno K, Kitazume MT, Mori M, Sugita A, Koganei K,Matsuoka K, Kanai T, Hibi T.
  • Journal Title: Gut. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] A Case of Intestinal Behçet's Disease Treated with Infliximab Monotherapy Who Successfully Maintained Clinical Remission and Complete Mucosal Healing for Six Years. (2012)
  • Author(s): Maruyama Y, Hisamatsu T, Matsuoka K, Naganuma M, Inoue N, Ogata H, Iwao Y, Kanai T, Hibi T.
  • Journal Title: Intern Med. Volume: 51(16) Pages: 2125-9
  • NAID: 130002062319
  • Peer Reviewed
• [Journal Article] T-helper 17 and Interleukin-17-Producing Lymphoid Tissue Inducer-Like T Cells Make Different Contributions to Colitis in Mice. (2012)
  • Author(s): Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T.
  • Journal Title: Gastroenterology Volume: 143 Issue: 5 Pages: 1288-1297
  • DOI: 10.1053/j.gastro.2012.07.108
  • Peer Reviewed
• [Journal Article] Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells
  • Author(s): Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A
  • Journal Title: J Exp Med Volume: (in press)
  • Peer Reviewed
• [Journal Article] TGR5 signaling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
  • Author(s): Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, KoganeiK, Sugita A, Kanai T, Hibi T
  • Journal Title: Immunology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Anticoagulation therapy dramatically improved severe sigmoiditis with findings resembling inflammatory bowel disease, which was caused by mesenteric venous thrombosis
  • Author(s): Mikami Y, Kanai T, Iwasaki E, Naganuma M, Yamagishi Y, Shimoda M, Matsuoka K, Hisamatsu T, Iwao Y, Ogata H, Nakatsuka S, Mukai M, Hibi T
  • Journal Title: Clinical Journal of Gastroenterology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages.
  • Author(s): Chang J, Hisamatsu T, Shimamura K, Yoneno K, Adachi M, Naruse H, Igarashi T, Higuchi H, Matsuoka K, Kitazume MT, Ando S, Kamada N, Kanai T, and Hibi T
  • Journal Title: Hepatology Research Volume: (in press)
  • NAID: 10031194568
  • Peer Reviewed
• [Presentation] Early normalization of C-reactive protein (CRP)by infliximab is a predictive factor of sustained longterm clinical efficacy in crohn's disease. (2012)
  • Author(s): Kimura K, Matsuoka K, Kanai T, Okamoto S,Hisamatsu T, Inoue N, Yajima T, Ogata H, I wa o Y, Hibi T
  • Organizer: The 14th Meeting of International Conference on Ulcer Research
  • Place of Presentation: Tokyo
  • Year and Date: 2012-07-14
• [Presentation] Early normalization of C-reactive protein (CRP)by infliximab is a predictive factor of sustained long-term clinical efficacy in crohn’s disease. (2012)
  • Author(s): 26. Kimura K, Matsuoka K, Kanai T, Okamoto S, Hisamatsu T, Inoue N, Yajima T, Ogata H, Iwao Y, Hibi T
  • Organizer: The 14th Meeting of International Conference on Ulcer Research.
  • Place of Presentation: Tokyo