Direct Contribution of Mitochondorial Oxidative Stress to Hepatic Fibrogenesis
| Project/Area Number |
24659376
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Naoaki 東海大学, 医学部, 教授 (60096196)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 酸化ストレス / 肝線維化 / マクロファージ / 非アルコール性脂肪肝炎 / 肝線維症 / コラーゲン遺伝子 |
|---|
| Research Abstract |
Oxidative stress is considered to play a key role in the progression of chronic liver diseases. However, since production of oxidative stress may merely represent the consequences of cell damage and subsequent inflammation, it is virtually unknown whether oxidative stress is linked directly to fibrogenesis.
Hepatocytes isolated from Tet-mev-1 mouse, in which mitochondrial reactive oxygen species can be induced, exhibited decreased mitochondrial membrane potential. Tet-mev-1 mice were fed high fat/high sucrose (HFHS)diet, and microarray analyses indicated that CC chemokine expression was remarkably elevated in the liver tissue. However, the number of F4/80-positive cells was substantially decreased, and there was no
apparent liver fibrosis observed in Tet-mev-1 mice fed HFHS diet. These results suggested the important role of macrophages in the progression of liver fibrosis.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice2014
Author(s)
Yamaoka H, Sumiyoshi H, Higashi K, Nakao S, Minakawa K, Sumida K, Saito K, Ikoma N, Mabuchi T, Ozawa A, and Inagaki Y.
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Journal Title
J Dermatol Sci 2014
Volume: (in press)
Issue: 3
Pages: 204-213
DOI
Related Report
Peer Reviewed
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[Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression2013
Author(s)
Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
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Journal Title
Mol. Cancer Res.
Volume: 11
Issue: 11
Pages: 1437-1447
DOI
Related Report
Peer Reviewed
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[Journal Article] Qualitative Rather than Quantitative Changes Are Hallmarks of Fibroblasts in Bleomycin-Induced Pulmonary Fibrosis2013
Author(s)
Tatsuya Tsukui, Satoshi Ueha, Jun Abe, Shin-ichi Hashimoto, Shigeyuki Shichino, Takeshi Shimaoka, Francis H. W. Shand, Yasuka Arakawa, Kenshiro Oshima, Masahira Hattori, Yutaka
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Journal Title
The American Journal of Pathology
Volume: 3
Issue: 3
Pages: 758-773
DOI
Related Report
Peer Reviewed
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[Presentation] Identification of a novel bone marrow cell-derived factor that suppresses fibrogenesis and accelerates regeneration of murine fibrotic liver
Author(s)
Hideaki Sumiyoshi, Hiroshi Fukumitsu, Reiichi Higashiyama, Sachie Nakao, Kaori Minakawa, Minako Sueoka, Hiromi Chikada, Akihide Kamiya, Kiyoshi Higashi, Koichi Saito, Yutaka Inagaki
Organizer
The 20th Annual Meeting of the Japanese Society for the Research of Hepatic Cells
Place of Presentation
大阪
Related Report
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