| Project/Area Number |
24659378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KOJIMA Soichi 独立行政法人理化学研究所, 分子リガンド生物研究チーム, チームリーダ (10202061)
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| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | Transglutaminase 2 (TG2) / Tumor (cancer) / Retinoblastoma (RB) protein / Enhancer of Zeste Homologue 2 (EZH2) / Vasohibin 1 (VASH1) / 遺伝子 / 細胞・組織 / 食品 / 蛋白質 / 内科 / トランスグルタミナーゼ |
|---|
| Research Abstract |
We found an essential role of TG2 in tumor-induced angiogenesis through a comparison between TG2+/+ and TG2-/- mice, which show no abnormal manifestation during development. We provide evidence that TG2 controls crosslinking and phosphorylation of RB proteins and trans-activation of E2F that results in induction of EZH2, which suppresses an anti-angiogenic factor, vasohibin 1 (VASH1), thereby sustaining tumor angiogenesis. Thus, TG2 and under signaling molecules maybe a novel target for anti-angiogenic therapy against cancer, without affecting tissue remodeling.
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