Elucidation of cardiovascular pathologies by regulating the processing of the peptide
Project/Area Number |
24659383
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
SUZUKI Toru 東京大学, 医学部附属病院, 准教授 (90359620)
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Co-Investigator(Kenkyū-buntansha) |
AIZAWA Kenichi 東京大学, 医学部附属病院, 特任助教 (70436484)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 循環器・高血圧 / 蛋白質 / プロテオーム / ストレス / 動脈硬化 |
Research Abstract |
It is revealed that endocrine control participates in the condition of a patient of the cardiovascular disease and in late years attracts attention as the field of cardiovascular endocrinology. We pursued the generation mechanism of the fragment which selective bioactive peptide caught the processing to heart seen at the time of arteriosclerosis. We examined whether human recombinant performed a process of this bioactive peptide using a mass spectrometer. In addition, we performed examination whether or not the activity of this enzyme was seen in blood and examined correlation with the condition of a patient. As a result, in the coronary restenotic condition of a patient, we made clear that a piece of the specific bioactive peptide decreased. It is expected future arteriosclerotic new diagnostic agent, that, besides, it is a beginning of the development of the antiarteriosclerotic drug.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population : a cross-sectional study2013
Author(s)
Enokoku K, Ikeda H, Kato R, Kume Y, Yoshida H, Ono T, Aizawa K, Suzuki T, Yamzaki T, Yatomi Y.
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Journal Title
Clin. Chim. Acta
Volume: 421
Pages: 147-151
Related Report
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[Journal Article] Stroke and outcomes in patients with acute type A aortic dissection.2013
Author(s)
Bossone E, Corteville DC, Harris KM, Suzuki T, Fattori R, Hutchison S, Ehrlich MP, Pyeritz RE, Steg PG, Greason K, Evangelista A, Kline-Rogers E, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA.
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Journal Title
Circulation
Volume: 128
Issue: 11_suppl_1
DOI
Related Report
Peer Reviewed
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[Journal Article] Extent of preoperative false lumen thrombosis does not influence long-term survival in patients with acute type a aortic dissection.2013
Author(s)
Larsen M, Bartnes K, Tsai TT, Eagle KA, Evangelista A, Nienaber CA, Suzuki T, Fattori R, Froehlich JB, Hutchison S, Sundt TM, Januzzi JL, Isselbacher EM, Montgomery DG, Myrmel T
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Journal Title
J Am Heart Assoc
Volume: 2
Issue: 4
DOI
Related Report
Peer Reviewed
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[Journal Article] Type-selective benefits of medications in treatment of acute aortic dissection; (from the International Registry of Acute Aortic Dissection [IRAD])2012
Author(s)
Suzuki T , Isselbacher EM, Nienaber CA, Pyeritz RE, Eagle KA, Tsai TT, Cooper JV, Januzzi JL Jr, Braverman AC, Montgomery DG, Fattori R, Pape L, Harris KM, Booher A, Oh J, Peterson M, Ramanath VS, Froehlich JB.
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Journal Title
Am J Cardiol
Volume: 109
Pages: 122-127
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