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The novel fat-derived hormone as a therapeutic target for acute coronary syndrome

Research Project

Project/Area Number 24659384
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNagoya University

Principal Investigator

OUCHI NORIYUKI  名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)

Co-Investigator(Kenkyū-buntansha) OHASHI Koji  名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei  名古屋大学, 医学系研究科, 特任講師 (70343689)
MUROHARA Toyoaki  名古屋大学, 医学系研究科, 教授 (90299503)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords分子心臓病態学 / 急性冠症候群
Research Abstract

Here, we investigated the impacts of the fat-derived hormone omentin on acute myocardial injury in animal models of ischemia/reperfusion (I/R). We found that systemic administration of human omentin protein to mice reduced myocardial infarct size and apoptosis following I/R. Furthermore, intracoronary injection of omentin improved cardiac injury and dysfunction in a pig model of I/R. Thus, omentin represents a novel target molecule for the treatment of acute coronary syndrome.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (16 results) (of which Invited: 7 results)

  • [Journal Article] Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 152013

    • Author(s)
      Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N
    • Journal Title

      PLoS One

      Volume: 8(12) Issue: 12 Pages: e83183-e83183

    • DOI

      10.1371/journal.pone.0083183

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema2013

    • Author(s)
      Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N
    • Journal Title

      J Am Heart Assoc

      Volume: 2 Issue: 5

    • DOI

      10.1161/jaha.113.000438

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Reendothelialization by Induced Pluripotent Stem Cells After Vascular Injury2013

    • Author(s)
      Yamamoto T, Shibata R, Ishii M, Kanemura N, Kito T, Suzuki H, Miyake H, Maeda K, Tanigawa T, Ouchi N, Murohara T
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33 Issue: 9 Pages: 2218-21

    • DOI

      10.1161/atvbaha.113.301313

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis.2013

    • Author(s)
      Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.
    • Journal Title

      Sci Rep

      Volume: 11:3 Issue: 1 Pages: 1418-1418

    • DOI

      10.1038/srep01418

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation2013

    • Author(s)
      Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
    • Journal Title

      FASEB J

      Volume: 27 Issue: 1 Pages: 25-33

    • DOI

      10.1096/fj.12-213744

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models2012

    • Author(s)
      Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
    • Journal Title

      Circulation

      Volume: 126 Issue: 14 Pages: 1728-38

    • DOI

      10.1161/circulationaha.112.115089

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Omentin as a novel biomarker of metabolic risk factors2012

    • Author(s)
      Shibata R, Ouchi N, Takahashi R, Terakura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T
    • Journal Title

      Diabetol Metab Syndr

      Volume: 4 Issue: 1 Pages: 37-37

    • DOI

      10.1186/1758-5996-4-37

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism2012

    • Author(s)
      Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 23 Pages: 18965-73

    • DOI

      10.1074/jbc.m112.357939

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] アディポサイトカインと血管病2013

    • Author(s)
      大内乗有
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮ソニックシティー(さいたま市)埼玉
    • Year and Date
      2013-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ディポサイトカインと心血管病2013

    • Author(s)
      大内乗有柴田玲大橋浩二室原豊明
    • Organizer
      第17回日本心血管内分泌代謝学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)大阪
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧合併症とアディポサイトカインの関連2013

    • Author(s)
      大内乗有柴田玲大橋浩二室原豊明
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(豊中市)大阪
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of adipocytokines in cardiovascular disease2013

    • Author(s)
      Ouchi N.
    • Organizer
      The 2nd International Congress on Lipid Metabolism & Atherosclerosis
    • Place of Presentation
      Seoul Korea
    • Year and Date
      2013-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of adipocytokines in the cardiovascular system2012

    • Author(s)
      Ouchi N.
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine (Fukuoka) Fukuoka, Japan
    • Year and Date
      2012-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 心血管系における新規アディポサイトカインの役割2012

    • Author(s)
      大内乗有
    • Organizer
      33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都市)京都
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] アディポサイトカインによる炎症調節機構2012

    • Author(s)
      大内乗有
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)福岡
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] アディポサイトカインによる疾患制御2012

    • Author(s)
      大内乗有
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      みやこめっせ(京都市)京都
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of adipocytokines in cardiovascular disease.

    • Author(s)
      大内乗有
    • Organizer
      The 2nd International Congress on Lipid Metabolism & Atherosclerosis
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 高血圧合併症とアディポサイトカインの関連

    • Author(s)
      大内乗有 柴田玲 大橋浩二 室原豊明
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(豊中市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アディポサイトカインと心血管病

    • Author(s)
      大内乗有 柴田玲 大橋浩二 室原豊明
    • Organizer
      第17回日本心血管内分泌代謝学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アディポサイトカインと血管病

    • Author(s)
      大内乗有
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮ソニックシティー(埼玉県さいたま市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アディポサイトカインによる炎症調節機構

    • Author(s)
      大内乗有
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] アディポサイトカインによる疾患制御

    • Author(s)
      大内乗有
    • Organizer
      第49回日本臨床分子医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 心血管系における新規アディポサイトカインの役割

    • Author(s)
      大内乗有
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Role of adipocytokines in the cardiovascular system

    • Author(s)
      大内乗有
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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