| Project/Area Number |
24659384
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei 名古屋大学, 医学系研究科, 特任講師 (70343689)
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子心臓病態学 / 急性冠症候群 |
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| Research Abstract |
Here, we investigated the impacts of the fat-derived hormone omentin on acute myocardial injury in animal models of ischemia/reperfusion (I/R). We found that systemic administration of human omentin protein to mice reduced myocardial infarct size and apoptosis following I/R. Furthermore, intracoronary injection of omentin improved cardiac injury and dysfunction in a pig model of I/R. Thus, omentin represents a novel target molecule for the treatment of acute coronary syndrome.
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