Significance of reciprocal expression of myocardian and MRTF-A during the development of vascular disease

• Project/Area Number: 24659386
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: KUWAHARA Koichiro 京都大学, 医学(系)研究科(研究院), 講師 (30402887)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 分子血管病態学 / 転写調節 / 血管病変 / 動脈硬化 / 血管平滑筋

Research Abstract

Expression of myocardin-related transcription factor (MRTF)-A, a Rho signaling-responsive co-activator of serum response factor (SRF), was found to be increased in injured arteries and to be involved in the increase in proliferation and migration capacity in undifferentiated, activated vascular smooth muscle cells. Moreover, the MRTF-A inhibitor CCG1423 significantly reduced neointima formation following vascular injury in mice. MRTF-A could thus be a novel therapeutic target for the treatment of vascular diseases.

Research Products

• [Journal Article] The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis (2014)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
  • Journal Title: PLoS One Volume: 9(3)
  • NAID: 120007100132
• [Journal Article] The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis. (2014)
  • Author(s): Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
  • Journal Title: PLoS One Volume: 25 Issue: 3 Pages: e92314-e92314
  • DOI: 10.1371/journal.pone.0092314
  • NAID: 120007100132
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage-Specific Manner with Pluripotent Stem Cells (2013)
  • Author(s): Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK.
  • Journal Title: Circ Cardiovasc Genet Volume: 6(6) Pages: 624-33
• [Journal Article] Role of NRSF/REST in the Regulation of Cardiac Gene Expression and Function (2013)
  • Author(s): Kuwahara K.
  • Journal Title: Circ J Volume: 77(11) Pages: 2682-6
  • NAID: 10031196813
• [Journal Article] Angiotensin II Type 1a receptor signaling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy (2013)
  • Author(s): Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K.
  • Journal Title: Br J Pharmacol Volume: 170(7) Pages: 1384-95
• [Journal Article] Adrenomedullin in Cardiovascular Disease : A Useful Biomarker, Its Pathological Roles and Therapeutic Application (2013)
  • Author(s): Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Nakao K.
  • Journal Title: Curr Protein Pept Sci Volume: 14(4) Pages: 256-267
• [Journal Article] Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts (2013)
  • Author(s): Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K.
  • Journal Title: J Am Heart Assoc Volume: 2(3)
• [Journal Article] Cardiac nuclear High Mobility Group Box 1 prevents the development of cardiac hypertrophy and heart failure (2013)
  • Author(s): Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe JI, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
  • Journal Title: Cardiovasc Res Volume: 99(4) Pages: 657-64
• [Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure (2013)
  • Author(s): Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K.
  • Journal Title: PLoS One Volume: 8(1)
  • NAID: 120005241437
• [Journal Article] Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16 (2013)
  • Author(s): Matsumoto E, Sasaki S, Kinoshita H, Kito T, Ohta H, Konishi M, Kuwahara K, Nakao K, Itoh N.
  • Journal Title: Genes Cells Volume: 18(7) Pages: 544-553
• [Journal Article] Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice (2013)
  • Author(s): Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S.
  • Journal Title: Biochem Biophys Res Commun Volume: 434(2) Pages: 210-6
• [Journal Article] Determination of the B-type Natriuretic Peptide Level as a Criterion for Abnormalities in Japanese Individuals in Routine Clinical Practice : The J-ABS Multi-center Study (Japan Abnormal BNP Standard) (2013)
  • Author(s): Kawai M, Yoshimura M, Harada M, Mizuno Y, Hiramitsu S, Shimizu M, Shoda T, Kuwahara K, Miyagishima K, Ueshima K, Nakao K.
  • Journal Title: Intern Med Volume: 52(2) Pages: 171-7
  • NAID: 130003365857
• [Journal Article] Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells (2013)
  • Author(s): Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK
  • Journal Title: Circ Cardiovasc Genet Volume: 6(6) Issue: 6 Pages: 624-33
  • DOI: 10.1161/circgenetics.113.000330
  • Peer Reviewed
• [Journal Article] Role of NRSF/REST in the Regulation of Cardiac Gene Expression and Function (2013)
  • Author(s): Kuwahara K
  • Journal Title: Circ J Volume: 77 Pages: 2682-6
  • NAID: 10031196813
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy (2013)
  • Author(s): Yasuno, S., Kuwahara, K., Kinoshita, H., Yamada, C., Nakagawa, Y., Usami, S., Kuwabara, Y., Ueshima, K., Harada, M., Nishikimi, T., Nakao, K.
  • Journal Title: British Journal of Pharmacology Volume: 170(7) Issue: 7 Pages: 1384-1395
  • DOI: 10.1111/bph.12328
  • Peer Reviewed
• [Journal Article] Adrenomedullin in Cardiovascular Disease: A Useful Biomarker, Its Pathological Roles and Therapeutic Application (2013)
  • Author(s): Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Nakao K
  • Journal Title: Curr Protein Pept Sci Volume: 14 Pages: 256-267
  • Peer Reviewed
• [Journal Article] Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts. (2013)
  • Author(s): Kuwabara, Y., Kuwahara, K., Takano, M., Kinoshita, H., Arai, Y., Yasuno, S., Nakagawa, Y., Igata, S., Usami, S., Minami, T., Yamada, Y., Nakao, K., Yamada, C., Shibata, J., Nishikimi, T., Ueshima, K., Nakao, K.
  • Journal Title: Journal of the American Heart Association Volume: 2(3) Issue: 3
  • DOI: 10.1161/jaha.113.000150
  • Peer Reviewed
• [Journal Article] Cardiac nuclear High Mobility Group Box 1 prevents the development of cardiac hypertrophy and heart failure. (2013)
  • Author(s): Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe JI, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
  • Journal Title: Cardiovasc Res. Volume: 99 Issue: 4 Pages: 657-64
  • DOI: 10.1093/cvr/cvt128
  • Peer Reviewed
• [Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure (2013)
  • Author(s): Nishikimi, T., Okamoto, H., Nakamura, M., Ogawa, N., Horii, K., Nagata, K., Nakagawa, Y., Kinoshita, H., Yamada, C., Nakao, K., Minami, T., Kuwabara, Y., Kuwahara, K., Masuda, I., Kangawa, K., Minamino, N., Nakao, K.
  • Journal Title: PLoS ONE Volume: 8(1) Issue: 1 Pages: e53233-e53233
  • DOI: 10.1371/journal.pone.0053233
  • NAID: 120005241437
  • Peer Reviewed
• [Journal Article] Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice. (2013)
  • Author(s): Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S
  • Journal Title: Biochem Biophys Res Commun. Volume: 434 Issue: 2 Pages: 210-216
  • DOI: 10.1016/j.bbrc.2013.03.040
  • Peer Reviewed
• [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure. (2013)
  • Author(s): Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Minamino N, Nakao K.
  • Journal Title: Heart Volume: 99 Pages: 677-679
  • Peer Reviewed
• [Journal Article] [109th Scientific Meeting of the Japanese Society of Internal Medicine : symposium : 2. Translational research and evidence-based medicine (EBM) in internal medicine in Japan, translational research; 4) Translational research of endocrinology and metabolism] (2012)
  • Author(s): Hosoda K, Yasoda A, Ebihara K, Kuwahara K, Mukouyama M, Nakao K.
  • Journal Title: Nihon Naika Gakkai Zasshi Volume: 101(9) Pages: 2552-62
• [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure (2012)
  • Author(s): Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Minamino N, Nakao K.
  • Journal Title: Heart Volume: 99(10) Pages: 677-679
• [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice (2012)
  • Author(s): Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R and Nakao K.
  • Journal Title: EMBO J Volume: 31(23) Pages: 4428-40
• [Journal Article] In vivo site-specific transfection of naked plasmid DNA in mice using a tissue suction device (2012)
  • Author(s): Shimizu K, Kawakami S, Hayashi K, Kinoshita H, Kuwahara K, Nakao K, Hashida M, Konishi S.
  • Journal Title: Plos One Volume: 7(7)
• [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice. (2012)
  • Author(s): Minami T, Nakao K, et al
  • Journal Title: EMBO J. Volume: 31 Issue: 23 Pages: 4428-4440
  • DOI: 10.1038/emboj.2012.296
  • Peer Reviewed
• [Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure (2012)
  • Author(s): Nishikimi T, Nakao K, et al
  • Journal Title: Heart Volume: 98 Issue: 2 Pages: 152-161
  • DOI: 10.1136/heartjnl-2011-300102
  • Peer Reviewed
• [Journal Article] Fixed-dose combination therapy of candesartan cilexetil and amlodipine besilate for the treatment of hypertension in Japan. (2012)
  • Author(s): Yasuno S, Fujimoto A, Nakagawa Y, Kuwahara K, Ueshima K.
  • Journal Title: Expert Rev Cardiovasc Ther. Volume: 10(5) Issue: 5 Pages: 577-83
  • DOI: 10.1586/erc.12.34
  • Peer Reviewed
• [Journal Article] In vivo site-specific transfection of naked plasmid DNA in mice using a tissue suction device (2012)
  • Author(s): Shimizu K, Nakao K, et al
  • Journal Title: PloS One Volume: 0 Issue: 7 Pages: e41319-e41319
  • DOI: 10.1371/journal.pone.0041319
  • Peer Reviewed
• [Presentation] Contribution of renin-angiotensin system to the generation of arrhythmogenic substrate in mice with dilated cardiomyopathy and lethal arrhythmia (2013)
  • Author(s): Chinatsu Yamada, Koichiro Kuwahara, et al.
  • Organizer: 第30回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: San Diego
  • Year and Date: 2013-06-29
• [Presentation] Elucidation of molecular mechanisms underlying the regulation and action of cardiovascular hormones to find novel therapeutic targets for cardiovascular diseases (2013)
  • Author(s): Koichiro Kuwahara
  • Organizer: The77th Annual Scientific Meeting of The Japanese CirculationSociety
  • Place of Presentation: Pacifico Yokohama, Yokohama Japan
• [Presentation] Multi-organ communication in sudden arrhythmic death accompanied with heart failure (2013)
  • Author(s): Koichiro Kuwahara, Kazuwa Nakao
  • Organizer: The77th Annual Scientific Meeting of The Japanese CirculationSociety
  • Place of Presentation: Pacifico Yokohama, Yokohama Japan
• [Presentation] 心不全・突然死モデルマウスを用いた心不全の病態解明と新規治療標的の同定 (2013)
  • Author(s): 桑原宏一郎、中尾一和
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 血管壁ナトリウム利尿ペプチド系の意義の解明-血管内皮細胞特異的C型ナトリウム利尿ペプチド( C N P )ノックアウトマウスの解析- (2013)
  • Author(s): 中尾一泰桑原宏一郎錦見俊雄中川靖章木下秀之宇佐美覚桑原佳宏南丈也山田千夏山田優子保野慎治上嶋健治曽根正勝寒川賢治中尾一和
  • Organizer: 第50回臨床分子医学会
  • Place of Presentation: 東京
• [Presentation] 拡張型心筋症モデルマウスにおける左室リモデリング及び不整脈源性基質形成におけるレニン―アンジオテンシン系の意義 (2013)
  • Author(s): 山田千夏,桑原宏一郎,木下秀之,錦見俊雄,中尾一泰,桒原佳宏,中川靖章,中尾一和
  • Organizer: 第50回臨床分子医学会
  • Place of Presentation: 東京
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニンーアンジオテンシン系の検討 (2013)
  • Author(s): 山田千夏、桑原宏一郎、木下秀之、錦見俊雄、中尾一泰、桒原佳宏、保野慎治、中川靖章、上嶋健治、中尾一和
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 透析患者における血中N端proBNPの糖鎖修飾と測定系への影響について (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、中尾一和
  • Organizer: 第2回臨床高血圧フォーラム
  • Place of Presentation: JPタワーホール&カンファレンス(東京)
• [Presentation] 肺動脈性肺高血圧症に対する新規治療標的としてのTRPC3/6阻害効果の検討 (2013)
  • Author(s): 木下秀之、桑原宏一郎、清中茂樹、森泰生、赤木達、中村一文、桒原佳宏、中川靖章、錦見俊雄、中尾一和
  • Organizer: 第2回日本肺循環学会学術集会
  • Place of Presentation: 東京
• [Presentation] Myocardin-related transcription factor-A plays a pivotal role in vascular remodeling (2013)
  • Author(s): Koichiro Kuwahara, Kazuwa Nakao
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 東京
• [Presentation] Effect of O-linked Glycosylation of plasma N-terminal proBNP on NT-proBNP assay in hemodyalysis patients (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、中尾一和
  • Organizer: 心筋代謝研究会
  • Place of Presentation: キャノンマーケティングジャパン株式会社3階ホール(東京)
• [Presentation] 透析患者における血中B型(脳性)ナトリウム利尿ペプチド前駆体proBNPについての検討 (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、中尾一和
  • Organizer: 第61回心臓病学会
  • Place of Presentation: ホテル日航熊本、鶴やホール(熊本)
• [Presentation] TRPC3/6阻害による肺動脈性肺高血圧症抑制効果の検討 (2013)
  • Author(s): 木下秀之、桑原宏一郎、清中茂樹、森泰生、赤城達、中村一文、山田千夏、桒原佳宏、中川靖章、中尾一和
  • Organizer: 第1回日本肺高血圧学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 透析中の末期腎不全患者における血中proBNPについての検討 (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、南野直人、中尾一和
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] Impact of C-type Natriuretic Peptide Derived from Vascular Endothelial Cells on Blood Pressure (2013)
  • Author(s): Kazuhiro Nakao, Koichiro Kuwahara, Toshio Nishikimi, Yasuaki Nakagawa, Satoru Usami, Hideyuki Kinoshita, Takeya Minami, Yoshihiro Kuwabara, Chinatsu Yamada, Yuko Yamada, Takeshi Tokudome, Yoko M. Nakao, Shinji Yasuno, Kenji Kangawa
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] ナトリウム利尿ペプチド発現制御機構解明による心血管病治療標的の同定 (2013)
  • Author(s): 桑原宏一郎
  • Organizer: 第17回日本心血管内分泌代謝学会総会
  • Place of Presentation: 千里、大阪
• [Presentation] 維持血液透析患者における血中B型(脳性)ナトリウム利尿ペプチド前駆体についての検討 (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、中尾一和
  • Organizer: 第17回日本心血管内分泌代謝学会総会
  • Place of Presentation: 千里、大阪
• [Presentation] 維持血液透析患者におけるproBNPについての検討 (2013)
  • Author(s): 中川靖章、錦見俊雄、桑原宏一郎、保野慎治、木下秀之、桒原佳宏、中尾一泰、山田千夏、上嶋健治、中尾一和
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉)
• [Presentation] 血管壁ナトリウム利尿ペプチド系の意義の解明－血管内皮細胞特異的C型ナトリウム利尿ペプチド(CNP)ノックアウトマウスの解析－ (2013)
  • Author(s): 中尾一泰 桑原宏一郎 錦見俊雄 中川靖章 木下秀之 宇佐美覚 桑原佳宏 南丈也 山田千夏 山田優子 保野慎治 上嶋健治 曽根正勝 寒川賢治 中尾一和
  • Organizer: 第50回 臨床分子医学会
  • Place of Presentation: 東京
• [Presentation] 拡張型心筋症モデルマウスにおける左室リモデリング及び不整脈源性基質形成におけるレニン―アンジオテンシン系の意義 (2013)
  • Author(s): 山田 千夏, 桑原 宏一郎,木下 秀之, 錦見 俊雄, 中尾 一泰, 桒原 佳宏,中川 靖章, 中尾 一和
  • Organizer: 第50回 臨床分子医学会
  • Place of Presentation: 東京
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニンーアンジオテンシン系の検討 (2013)
  • Author(s): 山田千夏、桑原宏一郎、木下秀之、錦見俊雄、中尾一泰、桒原佳宏、保野慎治、中川靖章、上嶋健治、中尾一和
  • Organizer: 第86回 日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 肺動脈性肺高血圧症に対する新規治療標的としてのTRPC3/6阻害効果の検討 (2013)
  • Author(s): 木下秀之、桑原宏一郎、清中茂樹、森泰生、赤木達、中村一文、桒原佳宏、中川靖章、錦見俊雄、中尾一和
  • Organizer: 第2回 日本肺循環学会学術集会
  • Place of Presentation: 東京
• [Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure (2012)
  • Author(s): Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Yasuaki Nakagawa, Chinatsu Yamada, Takeya Minami, Shinji Yasuno, Kazuhiro Nakao, Toshio Nishikimi, Kenji Ueshima, Yasuo Mori, Wataru Shimizu, Kenji Kangawa, Kazuwa Nakao
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 福岡
• [Presentation] Reciprocal expression of MRTF-A and Myocardin is crucial for pathological vascular remodeling in mice (2012)
  • Author(s): Takeya Minami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Kazuhiro Nakao, Yoshihiro Kuwabara, Toshio Nishikimi, Kazuwa Nakao
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 福岡
• [Presentation] Neurohumoral regulation in the process of pathological cardiac remodeling (2012)
  • Author(s): Koichiro Kuwahara, Kazuwa Nakao
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会(Symposium)
  • Place of Presentation: 福岡
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討 (2012)
  • Author(s): 山田千夏桑原宏一郎木下秀之錦見俊雄桑原佳宏南丈也中尾一泰中川靖章中尾一和
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京都
• [Presentation] 血管リモデリングにおける新規治療標的としてのRho依存性転写共役因子MRTF-Aの意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
  • Organizer: 第49回日本臨床分子医学会
  • Place of Presentation: 京都
• [Presentation] ｍｉＲ－１を介したＲｈｏ依存性転写共役因子ＭＲＴＦ－Ａ発現制御の血管リモデリングにおける意義 (2012)
  • Author(s): 南 丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・錦見俊雄・中尾一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 拡張型心筋症マウスにおけるN型Ca2+チャネル阻害による自律神経活性調節を介した不整脈突然死予防の有用性 (2012)
  • Author(s): 山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章、柴田純子、山田千夏、南丈也、保野慎治、宇佐美覚、中尾一泰、錦見俊雄、上嶋健治、森泰生、中尾一和
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 慢性心不全・突然死モデルマウスの不整脈源性基質形成における、レニンーアンジオテンシン系の関与の検討 (2012)
  • Author(s): 山田千夏 桑原宏一郎 木下秀之 桒原佳宏 南丈也 中尾一泰 宇佐美覚 保野慎治 中川靖章 錦見俊雄 上嶋健治 中尾一和
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Neurohumoral regulation in the process of pathological cardiac remodeling (2012)
  • Author(s): Koichiro Kuwahara, Kazuwa Nakao
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討 (2012)
  • Author(s): 山田 千夏 桑原 宏一郎 木下 秀之 錦見 俊雄 桑原 佳宏 南 丈也 中尾 一泰 中川 靖章 中尾 一和
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京
• [Presentation] Reciprocal expression of MRTF-A and myocardin mediated by miR-1 is crucial for phenotypic modulation of vascular smooth muscle cells (2012)
  • Author(s): Takeya Minami, Koichiro Kuwahara, Yasuaki Nakagawa, Hideyuki Kinoshita, Kazuhiro Nakao, Yoshihiro Kuwabara, Yuko Yamada, Chinatsu Yamada, Junko Shibata, Kazuwa Nakao, et al.
  • Organizer: Arteriosclerosis, Thrombosis and Vascular BiologyScientific Session 2012
  • Place of Presentation: Chicago
• [Presentation] Molecular mechanisms underlying cardioprotective effects of natriuretic peptides (2012)
  • Author(s): Koichiro Kuwahara, Kazuwa Nakao
  • Organizer: The 7th Oulu Symposium
  • Place of Presentation: Oulu
  • Invited
• [Presentation] Overexpression of HCN Channels in Failing Heart Contributes to Increased Ventricular Arrhythmicity (2012)
  • Author(s): Yoshihiro Kuwabara, Koichiro Kuwahara, Hideyuki Kinoshita, Makoto Takano, Yasuaki Nakagawa, Satoru Usami, Kazuhiro Nakao, Takeya Minami, Yuko Yamada, Chinatsu Yamada, Kazuwa Nakao, et al.
  • Organizer: Basic Cardiovascular Sciences 2012 Scientific Sessions
  • Place of Presentation: New Orleans
• [Presentation] Direct renin inhibitor prevents ventricular remodeling and sudden arrhythmic death in mice with dilated cardiomyopathy (2012)
  • Author(s): C. Yamada, K. Kuwahara, T. Minami, Y. Kuwabara, K. Nakao, H. Kinoshita, S. Usami, Y. Nakagawa, T. Nishikimi, K. Nakao
  • Organizer: 2012年欧州心臓学会議
  • Place of Presentation: Munich
• [Presentation] Direct Renin Inhibitor Strongly Prevents Ventricular Arrhythmogenic Remodeling and Sudden Cardiac Death in Mice with Dilated Cardiomyopathy (2012)
  • Author(s): Chinatsu Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Takeya Minami, Kazuhiro Nakao, Shinji Yasuno, Yasuaki Nakagawa, Kenji Ueshima, Kazuwa Nakao,
  • Organizer: 2012年米国心臓病学会議
  • Place of Presentation: Los Angels
• [Book] ガイドライン外来診療2014 (2014)
  • Author(s): 桑原宏一郎、木村剛
  • Publisher: 日経メディカル開発
• [Book] 変貌する心不全診療 (2013)
  • Author(s): 中川靖章、桑原宏一郎
  • Publisher: 南江堂
• [Book] 南江堂 (2013)
  • Author(s): 中川靖章、桑原宏一郎など
  • Total Pages: 310
  • Publisher: 変貌する心不全治療
• [Book] 心不全診療Q&A-エキスパート64人からの回答 (2012)
  • Author(s): 桑原宏一郎など
  • Total Pages: 446
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
• [Remarks] 京都大学大学院医学研究科内分泌代謝内科学講座 心臓グループ
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html
• [Remarks] 京都大学大学院医学研究科内科学講座 内分泌代謝内科学 心臓グループ
  • URL: http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html