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The role of sarcomere-specific isoform of docking protein Gab1in heart failure

Research Project

Project/Area Number 24659391
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

NAKAOKA Yoshikazu  大阪大学, 医学系研究科, 助教 (90393214)

Co-Investigator(Renkei-kenkyūsha) KOMURO Issei  東京大学, 医学系研究科, 教授 (30260483)
Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsGab1 / ドッキングタンパク質 / neuregulin-1 / サルコメア / アイソフォーム
Research Abstract

We are focusing on the role of Gab docking proteins in the cardiovascular field. In the present study, we identified a novel isoformof Gab1 (120 kDa) expressed exclusively in cardiac muscle and skeletal muscle, which is different from a ubiquitous isoform of Gab1 expressed in all the tissues. We succeeded in cloning of sarcomere-specific Gab1 isoform cDNA and found the existence of extra-exon in sarcomere-specific Gab1 isoform in mammals. RT-PCR analysis revealed that the expression of this extra-exon was confined to myocardium and skeletal muscle in mice. In addition, we created rabbit polyclonal antibody specific to the amino acid sequences of this extra-exon, and found that this isoform is indeed expressed in the embryonic murine heart at E12.5.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (34 results)

All 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (18 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Gab docking proteins in cardiovascular disease, cancer, and inflammation2013

    • Author(s)
      Nakaoka Y.
    • Journal Title

      International Journal of Inflammation 2012 Article ID 141068

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大型血管炎-高安病を中心に2013

    • Author(s)
      中岡良和
    • Journal Title

      臨床検査

      Volume: 57 Pages: 298-305

    • Related Report
      2012 Final Research Report
  • [Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway.2013

    • Author(s)
      Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y
    • Journal Title

      Cell Mol Life Sci

      Volume: 70 Issue: 6 Pages: 1123-1133

    • DOI

      10.1007/s00018-012-1198-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gab docking proteins in cardiovascular disease, cancer, and inflammation2013

    • Author(s)
      Nakaoka Y, Komuro I
    • Journal Title

      Int J Inflam

      Volume: 2013 Pages: 141068-141068

    • DOI

      10.1155/2013/141068

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大型血管炎―高安病を中心に2013

    • Author(s)
      中岡良和
    • Journal Title

      臨床検査

      Volume: 57 Pages: 298-305

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation andAtherosclerosis in Apolipoprotein E Knockout Mice2012

    • Author(s)
      Higuchi K
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 2031-2040

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akttransduction pathway2012

    • Author(s)
      Rodriguez-Araujo G
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 70 Pages: 1123-1133

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管体性幹細胞2012

    • Author(s)
      中岡良和
    • Journal Title

      BioClinica

      Volume: 27 Pages: 844-848

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] トラスツズマブの心毒性から明らかにされたNeuregulin-1/ErbBシグナルの重要性2012

    • Author(s)
      中岡良和
    • Journal Title

      心臓

      Volume: 44 Pages: 698-699

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 高安動脈炎の治療2012

    • Author(s)
      中岡良和
    • Journal Title

      日本臨床(増刊号 血管炎)

      Volume: 71 Supple 1 Pages: 173-178

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation and Atherosclerosis in Apolipoprotein E Knockout Mice2012

    • Author(s)
      Higuchi K
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 8 Pages: 2031-2040

    • DOI

      10.1253/circj.CJ-11-1507

    • NAID

      10030505176

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高安動脈炎の治療2012

    • Author(s)
      中岡良和
    • Journal Title

      日本臨床 (増刊号 血管炎)

      Volume: 71 Supple 1 Pages: 173-178

    • Related Report
      2012 Annual Research Report
  • [Presentation] Tocilizumab Ameliorates Vascular Inflammation and Clinical Symptoms in the Patients with TakayasuArteritis Refractory to Glucocorticoids2013

    • Author(s)
      Nakaoka Y
    • Organizer
      American College of Cardiology (ACC) 2013
    • Place of Presentation
      米国カリフォルニア州サンフランシスコ
    • Related Report
      2012 Final Research Report
  • [Presentation] Blockade of Interleukin-6 (IL-6) signaling by Anti-IL-6 Receptor Monoclonal Antibody might be aPromising Therapeutic Strategy for Pulmonary Arterial Hypertension2013

    • Author(s)
      Nakaoka Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiopoietin-1 Derived fromcardiomyocytes is Essential for Coronary Vein Formation through Attraction of Tie2-positive Endothelial Cells from Sinus Venosus.2013

    • Author(s)
      Arita Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Blockaede of interleukin-6 signaling might be a promising therapeutic option for pulmonary arterial hypertension via regulating macrophage polarization.2013

    • Author(s)
      Hashimoto-Kataoka T
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Tocilizumab Ameliorates Vascular Inflammation and Clinical Symptoms in the Patients with Takayasu Arteritis Refractory to Glucocorticoids2013

    • Author(s)
      Nakaoka Y
    • Organizer
      American College of Cardiology (ACC) 2013
    • Place of Presentation
      米国カリフォルニア州サンフランシスコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Blockade of Interleukin-6 (IL-6) signaling by Anti-IL-6 Receptor Monoclonal Antibody might be a Promising Therapeutic Strategy for Pulmonary Arterial Hypertension2013

    • Author(s)
      Nakaoka Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Angiopoietin-1 Derived from cardiomyocytes is Essential for Coronary Vein Formation through Attraction of Tie2-positive Endothelial Cells from Sinus Venosus2013

    • Author(s)
      Arita Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Blockaede of interleukin-6 signaling might be a promising therapeutic option for pulmonary arterial hypertension via regulating macrophage polarization.2013

    • Author(s)
      Hashimoto-Kataoka T
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Angiopoietin-1 is critical for coronary venogenesis in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      17th International Vascular Biology Meeting 2012
    • Place of Presentation
      Wiesbaden, Germany
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ENdothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation andatherosclerosis in apolipoprotein E knockout mice2012

    • Author(s)
      Nakaoka Y
    • Organizer
      17th International Vascular Biology Meeting 2012
    • Place of Presentation
      Wiesbaden, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] 低酸素誘発性肺高血圧マウスに対するIL-6受容体拮抗薬の発症抑制効果2012

    • Author(s)
      橋本崇弘
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      キロロホテルピアノ
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] アンジオポイエチン1の冠静脈の特異化及び遊走における役割2012

    • Author(s)
      有田陽
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      キロロホテルピアノ
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiopoietin-1 is essential for coronary vein formation in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      American Heart Association Scientific Session 2012
    • Place of Presentation
      米国カリフォルニア州ロサンゼルス
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Angiopoietin-1 is essential for coronary vein formation in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      第20回日本血管生物医学会 YIA competition
    • Place of Presentation
      徳島、あわぎんホール
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ENdothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice2012

    • Author(s)
      Nakaoka Y
    • Organizer
      17th International Vascular Biology Meeting 2012
    • Place of Presentation
      Wiesbaden, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] アンジオポイエチン1の冠静脈の特異化及び遊走における役割2012

    • Author(s)
      有田陽
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      北海道キロロ、ホテルピアノ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素誘発性肺高血圧マウスに対するIL-6受容体拮抗薬の発症抑制効果2012

    • Author(s)
      片岡崇弘
    • Organizer
      第1回肺循環学会
    • Place of Presentation
      東京、東京ステーションコンファレンス
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素誘発性肺高血圧マウスに対するIL-6受容体拮抗薬の発症抑制効果

    • Author(s)
      片岡崇弘
    • Organizer
      第1回肺循環学会
    • Place of Presentation
      東京ステーションコンファレンス
    • Related Report
      2012 Final Research Report
  • [Book] 血管新生研究の最先端2013

    • Author(s)
      中岡良和
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 血管新生研究の最先端 (8章2)Angiopoietin/Tie受容体)2013

    • Author(s)
      中岡良和
    • Total Pages
      331
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/cardiology/27research/2784res.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学大学院医学系研究科循環器内科学・心血管サイトカイン制御グループ

    • URL

      http://www.med.osaka-u.ac.jp/pub/cardiology/27research/2781res.html

    • Related Report
      2012 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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