PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis
| Project/Area Number |
24659395
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
SANO Motoaki 慶應義塾大学, 医学部, 講師 (30265798)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 分子心臓病態学 / 線維化 / 慢性腎臓病 / プロスタグランジン / Ｔ細胞 / サイトカイン |
|---|
| Research Abstract |
Urinary excretion of lipocalin-type PGD(2) synthase (L-PGDS), which converts PG H(2) to PGD(2), increases in early diabetic nephropathy. In addition, L-PGDS expression in the tubular epithelium increases in adriamycin-induced nephropathy, suggesting that
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Report
(2 results)
Research Products
(13 results)
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[Journal Article] Lipocalin-type prostaglandin D2 synthase promotes renal interstitial fibrosis via Th2 lymphocyte activation in unilateral ureteral obstruction2012
Author(s)
Ito H, Sano M, Nagata N, Aritake K, Katsumata Y, Xiaoxiang Y, Morizane S, Matsuhashi T, Urade Y, Asano K, Utsunomiya Y, Hosoya T, Fukuda K
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Journal Title
J Am Soc Nephrol.
Volume: 23
Pages: 1797-809
Related Report
Peer Reviewed
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