| Project/Area Number |
24659397
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Toho University (2013-2014)
Tohoku University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Yukitsuka 東北大学, 加齢医学研究所, 教授 (80375203)
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| Research Collaborator |
OKUNI Ikuko
SATO Ryuhei
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 肺アミロイドーシス / in vivoイメージング / PETプローブ / 近赤外線 / アミロイド / 蛍光プローブ / PET / ブレオマイシン / コンゴレッド染色 / Aβ1-42 |
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| Outline of Final Research Achievements |
Pulmonary amyloidosis is a disease characterized by extracellular deposition of protein in an abnormal fibrillar form in the lung. The identification of amyloid requires biopsy procedures and Congo red staining that produces green birefringence under polarized light. However, the biopsy procedures have risk such as bleeding. Moreover, Congo red staining of amyloid is not a very sensitive test and requires adequate observer experience. Recently, amyroid imaging for Altzheimer disease has been developed using flurocent probes. These probes might be useful for amyloid imaging for lung amyloidosis. Therefore, the ultimate aim of this study was to estabilsh the method for amyloid imaging for the lung amyloidosis. To achieve this model poupose, we developed a mouse model for pulmonary amyloidosis. Using this model and THK-265, we detected amyloid deposition in the lung. The results suggest that it is feasible to perform amyloid imaging for pulonary amyloidosis patients.
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