Familial pathogenesis of lung cancer with the epidermal growth factor receptor (EGFR) gene mutation
| Project/Area Number |
24659399
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KIKUCHI Toshiaki 東北大学, 医学(系)研究科(研究院), 非常勤講師 (10280926)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Yoichi , 国立成育医療研究センター, 所長 (00209602)
INOUE Akira 東北大学, 病院, 准教授 (70361087)
SAKAKIBARA Tomohiro 東北労災病院, 副部長 (80422111)
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| Research Collaborator |
TODE Naoki 東北大学, 病院, 医員
HIRANO Taizou 東北大学, 大学院医学系研究科, 非常勤講師
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 家族性癌 / エクソーム解析 |
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| Outline of Final Research Achievements |
Lung cancer is globally the leading cause of cancer death with the estimated number of the annual deaths as around 1.4 million. Cigarette smoking is a predominant etiological factor of lung carcinogenesis. Further attention has been paid to a growing number of lung carcinomas occurring in never-smokers, suggesting a biologically different disease with a genetic susceptibility. In this regard, the epidermal growth factor receptor (EGFR) gene mutation is more frequent in lung adenocarcinomas of never smokers. In this study, we acquired two 2-generational pedigrees containing more than 2 family members affected with lung adenocarcinoma with EGFR gene mutations, and performed exome capture and sequencing of whole-blood DNA. A de novo mutation was identified in lung cancer patients, but was not in two control subjects. The mutation alters the amino acid sequence, and confers dominant-negative activity that potentially underlies the pathogenesis of EGFR-mutated lung adenocarcinoma.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia.2015
Author(s)
Nihei M, Okazaki T, Ebihara S, Kobayashi M, Niu K, Gui P, Tamai T, Nukiwa T, Yamaya M, Kikuchi T, Nagatomi R, Ebihara T, Ichinose M.
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Journal Title
J Pathol
Volume: ;235
Issue: 4
Pages: 632-45
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mesenchymal Stem Cells Correct Inappropriate Epithelial-mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1.2015
Author(s)
Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
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Journal Title
Mol Ther
Volume: 23
Issue: 3
Pages: 549-560
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy.2015
Author(s)
Shibahara I, Saito R, Zhang R, Chonan M, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, Tominaga T.
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Journal Title
Mol Cancer.
Volume: 14
Pages: 41-41
NAID
Related Report
Peer Reviewed
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[Journal Article] Mycobacterium avium genotype is associated with the therapeutic response to lung infection.2014
Author(s)
Kikuchi T, Kobashi Y, Hirano T, Tode N, Santoso A, Tamada T, Fujimura S, Mitsuhashi Y, Honda Y, Nukiwa T, Kaku M, Watanabe A, Ichinose M.
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Journal Title
Clin Microbiol Infect.
Volume: 20
Issue: 3
Pages: 256-262
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 非結核性抗酸菌症の治療2014
Author(s)
菊地利明
Organizer
第89回日本結核病学会総会
Place of Presentation
長良川国際会議場（岐阜県・岐阜市）
Year and Date
2014-05-09 – 2014-05-10
Related Report
Invited
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