| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have conducted GWAS for smoking behaviour using 1369 healthy Japanese adults. Smoking behaviour was evaluated by smoking status (current, ex or never) and smoking index. Although we failed to identify significant associations at any chromosomal regions at the GWAS level significance, some of the previously reported genes for smoking behaviour in non-Japanese populations showed some associations with smoking status and/or smoking index. These genes included genes encoding serotonin 2A receptor (HTR2A) and neurexin 1 (NRXN1). In 56 smoking individuals who completed 8 weeks of smoking cessation clinic, none of these genetic factors were related to success or failure of smoking cessation.
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