Genetic analysis of smoking behavior
Project/Area Number |
24659400
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 喫煙習慣 / 禁煙 / 遺伝因子 / 喫煙 / 禁煙外来 / 網羅的ゲノム解析 / ニコチン依存 / COPD / セロトニン / ニューレキシン / GWAS |
Outline of Final Research Achievements |
We have conducted GWAS for smoking behaviour using 1369 healthy Japanese adults. Smoking behaviour was evaluated by smoking status (current, ex or never) and smoking index. Although we failed to identify significant associations at any chromosomal regions at the GWAS level significance, some of the previously reported genes for smoking behaviour in non-Japanese populations showed some associations with smoking status and/or smoking index. These genes included genes encoding serotonin 2A receptor (HTR2A) and neurexin 1 (NRXN1). In 56 smoking individuals who completed 8 weeks of smoking cessation clinic, none of these genetic factors were related to success or failure of smoking cessation.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Genomewide association study identifies HAS2 as a novel susceptibility gene for adult asthma in a Japanese population2014
Author(s)
Yatagai Y, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Konno S, Nishimura M, Hizawa N
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Journal Title
Clin Exp Allergy
Volume: 44
Issue: 11
Pages: 1327-1334
DOI
Related Report
Peer Reviewed
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[Journal Article] The effects of a Gly16Arg ADRB2 polymorphism on responses to salmeterol or montelukast in Japanese patients with mild persistent asthma2014
Author(s)
Konno S, Hizawa N, Makita H, Shimizu K, Sakamoto T, Kokubu F, Saito T, Endo T, Ninomiya H, Iijima H, Kaneko N, Ito YM, Nishimura M
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Journal Title
Pharmacogenet Genomics
Volume: 24
Issue: 5
Pages: 246-255
DOI
Related Report
Peer Reviewed
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[Journal Article] 北海道上士幌町における成人喘息,アレルギー性鼻炎有病率の検討―2006年,2011年の比較―2014
Author(s)
清水薫子, 今野 哲, 木村孔一, 荻 喬博,谷口菜津子, 清水健一, 伊佐田朗, 服部健史,檜澤伸之, 谷口正実, 赤澤 晃, 西村正治
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Journal Title
アレルギー
Volume: 63
Pages: 928-937
NAID
Related Report
Peer Reviewed
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[Journal Article] アレルゲン特異的IgE反応性から分類した喘息フェノタイプ―Thymic stromal lymphopoietin(TSLP)遺伝子と喫煙の役割―2014
Author(s)
飯島弘晃, 山田英恵, 谷田貝洋平, 金子美子, 内藤隆志, 坂本透, 増子裕典, 広田朝光, 玉利真由美, 今野哲, 西村正治, 檜澤伸之
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Journal Title
アレルギー
Volume: 63
Pages: 33-44
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of thymic stromal lymphopoietin (TSLP) genotypes on asthma phenotypes defined by the atopy cluster -influence of smoking habits-2014
Author(s)
Iijima H, Yamada H, Yatagai Y, Kaneko Y, Naito T, Sakamoto T, Masuko H, Hirota T, Tamari M, Konno S, Nishimura M, Hizawa N
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Journal Title
アレルギー
Volume: 63(1)
Pages: 33-44
NAID
Related Report
Peer Reviewed
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