Mechanisms for systemic inflammation in COPD

• Project/Area Number: 24659405
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Kochi University
• Principal Investigator: YOKOYAMA AKIHITO 高知大学, 教育研究部医療学系, 教授 (30191513)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Tetsuya 高知大学, 教育研究部医療学系, 准教授 (30274377) ; IKEZOE Takayuki 高知大学, 教育研究部医療学系, 講師 (80294833) ; OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: COPD / 併存症 / 内臓脂肪 / 全身性炎症 / 閉塞性肺疾患 / TNF

Research Abstract

We collected visceral fat tissues (n=120) during abdominal surgery for mainly early abdominal malignancies and investigated inflammatory cells including macrophages and cytokines. The COPD group having obstructive ventilatory impairment and smoking history did not have significantly increased number of macrophages which is a marker for fat tissue inflammation, when compared to non-smokers or healthy smokers. Further, in the COPD group with high serum CRP tended to have higher visceral fat macrophages than those with low CRP, but did not reach to be significant. In the entire study, both BMI and %VC were significantly correlated with the number of visceral fat macrophages independently by multivariate analysis. These results suggest that visceral fat inflammation is not involved in systemic inflammation of COPD, but is associated with lower lung volume.

Research Products

• [Journal Article] Cross-sectional and prospective study of the association between lung function and prediabetes (2013)
  • Author(s): Yamane T, Yokoyama A, Kitahara Y*, Miyamoto S, Haruta Y, Hattori N, Yamane K, Hara H, Kohno N
  • Journal Title: BMJ Open Volume: 3 Issue: 2 Pages: 3-3
  • DOI: 10.1136/bmjopen-2012-002179
  • NAID: 120006799354
  • Peer Reviewed
• [Journal Article] A novel lung injury animal model using KL-6-measurable human MUC1- expressing mice (2013)
  • Author(s): Sakai M, Kubota T, Ohnishi H, Yokoya ma A
  • Journal Title: Biochem Biophys Res Commun Volume: 432 Issue: 3 Pages: 460-5
  • DOI: 10.1016/j.bbrc.2013.01.123
  • Peer Reviewed
• [Journal Article] A novel treatment strategy targ eting shugoshin 1 in hematological ma lignancies (2013)
  • Author(s): Yang J, Ikezoe T, Nishioka C, Yokoya ma A.
  • Journal Title: Leuk Res Volume: 37 Pages: 76-82
  • Peer Reviewed
• [Journal Article] The combination of IκB kinase β inhibitor and everolimus modulates expression of inter leukin-10 in human T-cell lymphotropic virus type-1-infected T cells. (2013)
  • Author(s): Nishioka C
  • Journal Title: Immunology. Volume: 138 Issue: 3 Pages: 216-227
  • DOI: 10.1111/imm.12035
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Mishima M,et al.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 2 Pages: 305-312
  • DOI: 10.1016/j.jaci.2013.04.050
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases (2012)
  • Author(s): Ishikawa N, Hattori N, Yokoyama A, Kohno N
  • Journal Title: Respir Investig Volume: 50 Issue: 1 Pages: 3-13
  • DOI: 10.1016/j.resinv.2012.02.001
  • Peer Reviewed
• [Journal Article] Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels (2012)
  • Author(s): Horimasu Y, Hattori N, Ishikawa N, K awase S, Tanaka S, Yoshioka K, Yokoy ama A, Kohno N, Bonella F, Guzman J, Ohshimo S, Costabel U
  • Journal Title: Respir Med Volume: 106 Issue: 12 Pages: 1756-64
  • DOI: 10.1016/j.rmed.2012.09.001
  • Peer Reviewed
• [Journal Article] Levels of Surfactant proteins A and D, and KL-6 are elevated in the induced sputum of COPD ; a sequential sputum analysis (2011)
  • Author(s): Ishikawa N, et al
  • Journal Title: Respiration Volume: 82 Issue: 1 Pages: 10-18
  • DOI: 10.1159/000324539
  • Peer Reviewed
• [Journal Article] Chronic Hepatitis C Virus Infection is Associated with More Severe Asthma (2011)
  • Author(s): Nakashima T, Yokoyama A, Ohnishi H, 他7名
  • Journal Title: Allergology International Volume: 60 Issue: 3 Pages: 299-304
  • DOI: 10.2332/allergolint.10-OA-0240
  • NAID: 130004723041
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Effect of mustard gas exposure on incidence of lung cancer : a longitudinal study (2011)
  • Author(s): Doi M, Hattori N, Yokoyama A, Onari Y, Kanehara M, Masuda K, Tonda T, Ohtaki M, Kohno N
  • Journal Title: Am J Epidemiol Volume: 173 Issue: 6 Pages: 659-66
  • DOI: 10.1093/aje/kwq426
  • Peer Reviewed
• [Presentation] Low Lung Volume Is Associated W ith Adipose Tissue Inflammation (2013)
  • Author(s): Kawase S, Miyamoto S, Ohnishi H, Kub ota T, Namikawa T, Hanazaki, Yokoyam a A.
  • Organizer: 2013 American Thoracic Society Internati onal Conference
  • Place of Presentation: Phi ladelphia convention center,Philadel phia,USA
• [Presentation] Low lung volume i s associated with visceral adipose t issue inflammation (2013)
  • Author(s): S Kawase , M Takaoka, S Miyamoto ,H Ohnishi , T Kubota,T Namikawa,K Hana zaki , A Yokoyama.
  • Organizer: European Respira tory Society Annual Congress
  • Place of Presentation: Barcelona convention c enter, BARCELONA Spain
• [Presentation] Assessment of como rbidites in COPD (2013)
  • Author(s): Akihito Yokoyama.
  • Organizer: 18^<th> Congress of th e Asian Pacific Society of Respirolo gy
  • Place of Presentation: パシフィコ横浜,横浜
• [Presentation] Low Lung Volume Is Ass ociated With Visceral Adipose Tissue Inflammation (2013)
  • Author(s): Shigeo Kawase, Shintaro Miyamoto, Hi roshi Ohnishi, Tetsuya Kubota, Tsuto mu Namikawa, Kazuhiro Hanazaki, Akih ito Yokoyama.
  • Organizer: 18^<th> Congress of th e Asian Pacific Society of Respirolo gy
  • Place of Presentation: パシフィコ横浜,横浜
• [Presentation] Preoperative Pulmonary Dysfu nction And Comorbidities In Patients Undergoing Surgery (2013)
  • Author(s): Shigeo Kawase, Masato Takaoka, Mizu Sakai, Shintaro Miyamoto, Hiroshi Oh nishi, Tetsuya Kubota, Kazumasa Orih ashi, Kazuhiro Hanazaki , Akihito Yo koyama
  • Organizer: 18^<th> Congress of th e Asian Pacific Society of Respirolo gy
  • Place of Presentation: パシフィコ横浜,横浜
• [Presentation] Low Lung Volume Is Associated With Adipose Tissue Inflammation (2013)
  • Author(s): Kawase S,Miyamoto S,Ohnishi H,Kubota T,Namikawa T,Hanazaki K,Yokoyama A
  • Organizer: 2013 American Thoracic Society International Conference
  • Place of Presentation: Philadelphia
• [Presentation] Low lung volume is associated with visceral adipose tissue inflammation (2013)
  • Author(s): S Kawase , M Takaoka, S Miyamoto ,H Ohnishi , T Kubota,T Namikawa*,K Hanazaki *,
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: BARCELONA
• [Presentation] Assessment of comorbidites in COPD (2013)
  • Author(s): Akihito Yokoyama
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
  • Invited
• [Presentation] Preoperative Pulmonary Dysfunction And Comorbidities In Patients Undergoing Surgery (2013)
  • Author(s): Shigeo Kawase, Masato Takaoka, Mizu Sakai, Shintaro Miyamoto, Hiroshi Ohnishi,
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
• [Presentation] COPDと腹部脂肪炎症の関連に関する検討 (2013)
  • Author(s): 河瀬成穂
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
• [Presentation] Low lung volume is associated with abdominal adipose tissue inflammation (2013)
  • Author(s): Kawase S
  • Organizer: American Thoracic Society Annual Meeting
  • Place of Presentation: フィラデルフィア
• [Presentation] Lung func tion is inversely related to the inc idence of prediabetes (2011)
  • Author(s): Takashi Yamane, Akihito Yokoyama, Yo shihiro Kitahara, Yoshinori Haruta, Kiminori Yamane, Noboru Hattori, Hit oshi Hara, Nobuoki Kohno .
  • Organizer: EUROPEAN RESP IRATORY SOCIETY, ANNUAL CONGRESS
  • Place of Presentation: Amsterdam conven tion center,Netherlands
• [Book] 縦隔気腫.今日の治療指針2 013 (2013)
  • Author(s): 横山彰仁
  • Publisher: 医学書院
• [Book] CO2ナルコーシス.今日の治療と看護 (2013)
  • Author(s): 横山彰仁
  • Publisher: 南江堂
• [Book] 肺胞低換気症候群 (2013)
  • Author(s): 横山彰仁
  • Publisher: 医歯薬出版
• [Book] 一般検査所見の評価.特発性間質肺炎の治療と管理 (2013)
  • Author(s): 大西広志、横山彰仁
  • Publisher: 克誠堂出版
• [Book] 朝倉内科学 第10版 (2013)
  • Author(s): 横山彰仁
  • Total Pages: 3
  • Publisher: 朝倉書店
• [Book] 血液検査の読み方.間質肺炎を究める (2012)
  • Author(s): 横山彰仁
  • Publisher: メディカルビュー社
• [Book] 薬剤性肺炎・ガス・粉じんによる肺疾患 朝倉内科学第10版
  • Author(s): 横山彰仁