| Project/Area Number |
24659405
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Tetsuya 高知大学, 教育研究部医療学系, 准教授 (30274377)
IKEZOE Takayuki 高知大学, 教育研究部医療学系, 講師 (80294833)
OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | COPD / 併存症 / 内臓脂肪 / 全身性炎症 / 閉塞性肺疾患 / TNF |
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| Research Abstract |
We collected visceral fat tissues (n=120) during abdominal surgery for mainly early abdominal malignancies and investigated inflammatory cells including macrophages and cytokines. The COPD group having obstructive ventilatory impairment and smoking history did not have significantly increased number of macrophages which is a marker for fat tissue inflammation, when compared to non-smokers or healthy smokers. Further, in the COPD group with high serum CRP tended to have higher visceral fat macrophages than those with low CRP, but did not reach to be significant. In the entire study, both BMI and %VC were significantly correlated with the number of visceral fat macrophages independently by multivariate analysis. These results suggest that visceral fat inflammation is not involved in systemic inflammation of COPD, but is associated with lower lung volume.
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