Investigation of the protective effects of ghrelin on the disease progression of acute lung injury and its clinical application
| Project/Area Number |
24659406
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Nobuhiro 宮崎大学, 医学部, 助教 (70418838)
YANAGI Shigehisa 宮崎大学, 医学部, 助教 (60404422)
TSUBOUCHI Hironobu 宮崎大学, 医学部, 医員 (60573988)
ARIMURA Yasuji 宮崎大学, 医学部, 助教 (70534080)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 急性肺損傷 / トレンスレーショナルリサーチ / グレリン / 六君子湯 / ALI |
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| Research Abstract |
Ghrelin, an acylated peptide produced in the stomach, increases food intake and growth hormone secretion, suppresses inflammation. Rikkunshito (RKT) is known to stimulate ghrelin secretion. In this study, we examined the effects of RKT on acute lung injury (ALI) by using a ALI model in mice. The RKT-treated mice showed a definitively higher survival rate than control mice after injury. The amelioration of neutrophil alveolar infiltration, pulmonary vascular permeability, induction of proinflammatory cytokines, activation of the NF-kappa B pathway and lung fibrosis were notable in the RKT-treated mice. Our results indicate that RKT administration exerts protective effects against ALI. We also investigate the relationship between ghrelin levels and disease severity in ALI patients. Plasma ghrelin concentrations positively correlated with serum CRP levels and APACHEII scores in ALI patients. These data suggest that plasma ghrelin levels might reflect disease severity in ALI patients.
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Report
(3 results)
Research Products
(47 results)
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[Journal Article] Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity2013
Author(s)
Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, Nakazato M
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Journal Title
Am J Respir Crit Care Med
Volume: 187
Issue: 3
Pages: 262-275
DOI
Related Report
Peer Reviewed
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[Journal Article] Nighttime blood pressure, nighttime glucose values, and target-organ damages in treated type 2 diabetes patients.2013
Author(s)
Yano Y, Hayakawa M, Kuroki K, Ueno H, Yamagishi S, Takeuchi M, Eto T, Nagata N, Nakazato M, Shimada K, Kario K.
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Journal Title
Atherosclerosis
Volume: 227
Issue: 1
Pages: 135-139
DOI
Related Report
Peer Reviewed
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.2012
Author(s)
Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Issue: 4
Pages: 512-517
DOI
Related Report
Peer Reviewed
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[Journal Article] Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial.2012
Author(s)
Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K
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Journal Title
PLoS ONE
Volume: 7
Issue: 5
Pages: e35708-e35708
DOI
Related Report
Peer Reviewed
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