A comprehensive analysis of the TGF-beta family genes in the patients with abnormal pulmonary vessels
| Project/Area Number |
24659408
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 肺血管異常 / TGF-β / エキソーム / アミノ酸変異 / エクソーム / 血管異常 / 形態形成 / 肺 / エクソーム解析 / TGF-beta / アミノ酸変化 |
|---|
| Outline of Final Research Achievements |
Genomic DNA isolated from patients who has abnormal lung vessel structure has been investigated by exome sequencing. Non-synonymous variants found were as follows: pP2T in BMPR1A, pM630L in CHRD, pG213R in GDF-3, pS276A in GDF-5, pA330S in GDF-7, pV9L and pS48T in DGF-15, pD322A and pR33Q in LEFTY, pH165R in Nodal, pD399E, pD415E, and pD423E in RGMA, and c1314_1315insC in Smad5. The effects these variant gives to the pulmonary vessel structure should be investigated.
|
Report
(4 results)
Research Products
(2 results)
