Epigenetic mechanisms underlying renal derangement in hypertension and diabetes
Project/Area Number |
24659410
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
FUJITA Toshiro 東京大学, 先端科学技術研究センター, 特任研究員、名誉教授 (10114125)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 糖尿病性腎症 / 高血圧 / 食塩 / エピジェネティクス / 糖尿病 / DNAメチル化 |
Research Abstract |
Diabetes is often complicated with hypertension, but the underlying mechanisms have not been clarified. We investigated whether epigenetic derangement in the kidney underlies hypertension in diabetic model animals. Because kidney is composed with multiple cell types, we sorted proximal tubule cells and investigated the differential DNA methylation status. In normal mice, DNA methylation of multiple genes including those involved in blood pressure regulation was selectively demethylated in proximal tubules. In db/db mice, diabetic mice with salt sensitive hypertension, aberrant DNA methylation and mRNA changes were detected in some of the genes related to blood pressure regulation. These results suggest that epigenetic abnormalities may underlie hypertension in diabetes.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency.2014
Author(s)
Jimbo, R., Kawakami-Mori, F., Mu, S., Hirohama, D., Majtan, B., Shimizu, Y., Yatomi, Y., Fukumoto, S., Fujita, T., and Shimosawa, T.
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Journal Title
Kidney Int
Volume: in press
Issue: 5
Pages: 1103-1111
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.2013
Author(s)
Yamamoto, T., Izumi-Yamamoto, K., Iizuka, Y., Shirota, M., Nagase, M., Fujita, T., and Gotoda, T.
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Journal Title
Biochem Biophys Res Commun
Volume: 440
Issue: 4
Pages: 521-526
DOI
Related Report
Peer Reviewed
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