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Role of secreted FSP1 in the progression of diabetic nephropathy, especially in podocyte-mesangial crosstalk.

Research Project

Project/Area Number 24659415
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionUniversity of Fukui

Principal Investigator

IWANO MASAYUKI  福井大学, 医学部, 教授 (20275324)

Co-Investigator(Kenkyū-buntansha) KASUNO Kenji  福井大学, 医学部, 准教授 (60455243)
TAKAHASHI Naoki  福井大学, 医学部附属病院, 助教 (30377460)
MIKAMI Daisuke  福井大学, 医学部附属病院, 助教 (90464586)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsFSP1 / RAGE / ポドサイト / メサンギウム細胞 / FSP1 / RAGE
Research Abstract

FSP1-positive podocytes were observed in active glomerular damage. In this study, we investigated whether secreted FSP1 from podocytes has some biological effects on cultured mesangial cells through secreted FSP1 receptor, RAGE. We newly found that recombinant FSP1 induced five renoprotective factors and suppressed one factor associated with glomerular injury in cultured mesangial cells and these induction and suppression were not mediated through RAGE. These results suggest that secreted FSP1 has renoprotective effects and play a role in podocyte-mesangial crosstalk.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Down-regulation of renal type IIa sodium-dependent phosphate co-transporter during lipopolysaccharide-induced acute inflammation2014

    • Author(s)
      Ikeda S, Yamamoto H, Masuda M, Miyamoto K(他9名)
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 306(7) Issue: 7 Pages: 744-750

    • DOI

      10.1152/ajprenal.00474.2013

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014

    • Author(s)
      Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
    • Journal Title

      PLoS One.

      Volume: 9(1):e86301 Issue: 1 Pages: 1-1

    • DOI

      10.1371/journal.pone.0086301

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells.2014

    • Author(s)
      Mikami D, Iwano M, et al.
    • Journal Title

      Hypertens Res.

      Volume: 37 Issue: 5 Pages: 422-431

    • DOI

      10.1038/hr.2013.157

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease2014

    • Author(s)
      Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y.
    • Journal Title

      Kidney Int

      Volume: 85(2) Issue: 2 Pages: 393-403

    • DOI

      10.1038/ki.2013.339

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of renal biopsy in patients with presumed diabetic nephropathy2013

    • Author(s)
      Harada K, Akai Y, Sumida K, Yoshikawa M, Takahashi H, Yamaguchi Y, Kubo A, Iwano M, Saito Y.
    • Journal Title

      J Diabetes Invest

      Volume: 4 Issue: 1 Pages: 88-93

    • DOI

      10.1111/j.2040-1124.2012.00233.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid detection of the Mycobacterium tuberculosis complex by use of quenching probe PCR (geneCube)2012

    • Author(s)
      Hida Y, Hisada K, Shimada A, Yamashita M, Kimura H, Yoshida H, Iwasaki H, Iwano M.
    • Journal Title

      J Clin Microbiol

      Volume: 50(11) Issue: 11 Pages: 3604-8

    • DOI

      10.1128/jcm.01654-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 新規TLR4阻害因子・分泌型FSP1を介したポドサイトーメサンギウム細胞連関2014

    • Author(s)
      横井靖二、岩野正之, 他
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規TLR4阻害因子・分泌型FSP1を介したポドサイトーメサンギウム細胞連関2014

    • Author(s)
      横井靖二、糟野健司、高橋直生、三上大輔、横山由就、木村秀樹、岩野正之
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 結節病変を有した糖尿病性腎症例における腎予後と臨床および病理組織学的指標との関連性2012

    • Author(s)
      森本勝彦、岩野正之, 他
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 結節病変を有した糖尿病性腎症例における腎予後と臨床および病理組織学的指標との関連性2012

    • Author(s)
      森本勝彦、岩野正之
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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