Role of secreted FSP1 in the progression of diabetic nephropathy, especially in podocyte-mesangial crosstalk.
| Project/Area Number |
24659415
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASUNO Kenji 福井大学, 医学部, 准教授 (60455243)
TAKAHASHI Naoki 福井大学, 医学部附属病院, 助教 (30377460)
MIKAMI Daisuke 福井大学, 医学部附属病院, 助教 (90464586)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ＦＳＰ１ / ＲＡＧＥ / ポドサイト / メサンギウム細胞 / FSP1 / RAGE |
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| Research Abstract |
FSP1-positive podocytes were observed in active glomerular damage. In this study, we investigated whether secreted FSP1 from podocytes has some biological effects on cultured mesangial cells through secreted FSP1 receptor, RAGE. We newly found that recombinant FSP1 induced five renoprotective factors and suppressed one factor associated with glomerular injury in cultured mesangial cells and these induction and suppression were not mediated through RAGE. These results suggest that secreted FSP1 has renoprotective effects and play a role in podocyte-mesangial crosstalk.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014
Author(s)
Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
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Journal Title
PLoS One.
Volume: 9(1):e86301
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease2014
Author(s)
Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y.
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Journal Title
Kidney Int
Volume: 85(2)
Issue: 2
Pages: 393-403
DOI
Related Report
Peer Reviewed / Open Access
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