| Project/Area Number |
24659426
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Tetsuya 新潟大学, 医歯学総合病院, 助教 (20515663)
USUKI Fusako 国立水俣病総合研究センター, 臨床部, 室長 (50185013)
FUJIMURA Masatake 国立水俣病総合研究センター, 基礎研究 部・病理室, 室長 (20416564)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 水俣病 / メチル水銀中毒 / 血管内皮細胞増殖因子 / 血液脳関門 / VEGF / 小脳 / ラット |
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| Research Abstract |
Minamata disease and Niigata Minamata disease are methylmercury poisoning in Japan caused by environmental pollution. We analyzed the mechanism by which methyl-mercury causes brain damage from a standpoint of blood brain barrier (BBB) damage. We demonstrated that methylmercury caused up-regulation of vascular endothelial growth factor (VEGF) in rat brain, and caused BBB damage. We also demonstrated that VEGF inhibition by anti-VEGF neutralizing antibody may ameliorate brain damage associated with methylmercury poisoning.
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