| Project/Area Number |
24659435
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
SAIKI Shinji 順天堂大学, 医学部, 准教授 (00339996)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Kojiro 大阪工業大学, 情報科学部, 准教授 (10612442)
AMO Taku 防衛大学校, 応用化学群, 助教 (40453922)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳神経疾患 / 再生医療 / 細胞死 / オートファジー / 蛋白分解 / 国際情報交換 |
|---|
| Research Abstract |
20-30 % of HeLa cells transiently expressing PINK1/parkin, Parkinson's disease-asssociated genes, have shown apoptotic changes characterized by elevation of levels of cleaved caspase-8/9/3. The apoptosis induced by PINK1/parkin overexpression is inhibited by zVAD as well as caspase-8 inhibitors. Now we try to sort out cells with less mitochondria without apoptotic tendency and figure out the characteristics.
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