Analysis of mitochondrial regeneration with cellular models of Parkinson's disease
| Project/Area Number |
24659435
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
SAIKI Shinji 順天堂大学, 医学部, 准教授 (00339996)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Kojiro 大阪工業大学, 情報科学部, 准教授 (10612442)
AMO Taku 防衛大学校, 応用化学群, 助教 (40453922)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳神経疾患 / 再生医療 / 細胞死 / オートファジー / 蛋白分解 / 国際情報交換 |
|---|
| Research Abstract |
20-30 % of HeLa cells transiently expressing PINK1/parkin, Parkinson's disease-asssociated genes, have shown apoptotic changes characterized by elevation of levels of cleaved caspase-8/9/3. The apoptosis induced by PINK1/parkin overexpression is inhibited by zVAD as well as caspase-8 inhibitors. Now we try to sort out cells with less mitochondria without apoptotic tendency and figure out the characteristics.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] p150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.2014
Author(s)
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N
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Journal Title
PLOS ONE
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] ATP13A2 Deficiency Induces a Decrease in Cathepsin D Activity, Fingerprint-like Inclusion, and Selective Degeneration of Dopaminergic Neurons2013
Author(s)
Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.
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Journal Title
FEBS Letters
Volume: 587(9)
Pages: 1316-1325
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] p150glued-associated disorders are caused by activation of intrinsic apoptotic pathway
Author(s)
Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
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Journal Title
PLOS ONE
Volume: (in press)
Related Report
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