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Establishing the basic study for unmyelinated and myelinated central nervous system

Research Project

Project/Area Number 24659436
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

NUKINA Nobuyuki  独立行政法人理化学研究所, 脳科学総合研究センター, 客員主管研究員 (10134595)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords無髄線維 / 線条体投射線維 / sodium channel / beta4 subunit / Nav1.2 / ナトリウムチャンネル / 線条体中型有棘細胞 / 線条体 / 無髄神経
Outline of Final Research Achievements

The role of unmyelinated fiber in central nervous system is not well elucidated. Even which nervous system is unmylinated is well unknown. We recently found the striatal projection fibers are unmylinated suggested by the distribution pattern of sodium channel beta4 subunit. In this study we further confirm this fact and identified several features of those unmyelinated fibers(Miyazaki et al Nat Commun2014)

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.2015

    • Author(s)
      Wimmer VC, Harty RC, Richards KL, Phillips AM, Miyazaki H, Nukina N, Petrou S.
    • Journal Title

      J Comp Neurol.

      Volume: 523 Issue: 5 Pages: 814-30

    • DOI

      10.1002/cne.23715

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2014

    • Author(s)
      Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
    • Journal Title

      Nat Commun.

      Volume: 5 Issue: 1 Pages: 5525-5525

    • DOI

      10.1038/ncomms6525

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization2014

    • Author(s)
      Yamanaka, T., Tosaki, A., Kurosawa, M., Matsumoto, G., Koike, M., Uchiyama, Y., Maity, S.N., Shimogori, T., Hattori, N. & Nukina, N.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3354-3354

    • DOI

      10.1038/ncomms4354

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-22014

    • Author(s)
      Asada, A., Yamazaki, R., Kino, Y., Saito, T., Kimura, T., Miyake, M., Hasegawa, M., Nukina, N. & Hisanaga, S.
    • Journal Title

      Neurosci. Lett.

      Volume: 563 Pages: 112-117

    • DOI

      10.1016/j.neulet.2014.01.046

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease2014

    • Author(s)
      Maheshwari, M., Bhutani, S., Das, A., Mukherjee, R., Sharma, A., Kino, Y., Nukina, N. & Jana, N.R.
    • Journal Title

      Hum. Mol. Genet.

      Volume: 23 Issue: 10 Pages: 2737-2751

    • DOI

      10.1093/hmg/ddt667

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis2014

    • Author(s)
      Nomura, T., Watanabe, S., Kaneko, K., Yamanaka, K., Nukina, N. & Furukawa, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 2 Pages: 1192-1202

    • DOI

      10.1074/jbc.m113.516492

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains2013

    • Author(s)
      Yamanaka, T., Tosaki, A., Kurosawa, M., Akimoto, K., Hirose, T., Ohno, S., Hattori, N. & Nukina, N.
    • Journal Title

      PloS one

      Volume: 8 Issue: 12 Pages: e84036-e84036

    • DOI

      10.1371/journal.pone.0084036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis2013

    • Author(s)
      Furukawa, Y., Kaneko, K., Watanabe, S., Yamanaka, K. & Nukina, N.
    • Journal Title

      FEBS Lett.

      Volume: 587 Issue: 16 Pages: 2500-2505

    • DOI

      10.1016/j.febslet.2013.06.046

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional diversity of protein fibrillar aggregates from physiology to RNA granules to neurodegenerative diseases2013

    • Author(s)
      Furukawa, Y. & Nukina, N.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1832 Issue: 8 Pages: 1271-1278

    • DOI

      10.1016/j.bbadis.2013.04.011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of voltage-gated K+ channels by the sodium channel beta1 subunit2012

    • Author(s)
      Nguyen, H.M.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 109 Issue: 45 Pages: 18577-18582

    • DOI

      10.1073/pnas.1209142109

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012

    • Author(s)
      Klionsky, D. J.
    • Journal Title

      Autophagy

      Volume: 8 Pages: 445-544

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT2012

    • Author(s)
      Bauer PO
    • Journal Title

      Molecular Neurodegeneration

      Volume: 7(1) Issue: 1 Pages: 43-43

    • DOI

      10.1186/1750-1326-7-43

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates2012

    • Author(s)
      Mitomi, Y.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 41 Pages: 34764-34775

    • DOI

      10.1074/jbc.m112.387035

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates2012

    • Author(s)
      Ding, F.
    • Journal Title

      Journal of Molecular Biology

      Volume: 421 Issue: 4-5 Pages: 548-560

    • DOI

      10.1016/j.jmb.2011.12.029

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The pathomechanism of Huntington disease:factors related to its pathological cascades(ハンチントン病の分子病態)2015

    • Author(s)
      Nukina, N.
    • Organizer
      第120回日本解剖学会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸ポートアイランド)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Autophagic machinery for degrading the misfolded proteins2012

    • Author(s)
      Nukina, N.
    • Organizer
      The 6th International Symposium of Autophagy 2012
    • Place of Presentation
      Nago, Japan
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Role of NF-Y transcription factor in neuronal cell maintenance and chaperone gene expression2012

    • Author(s)
      Yamanaka, T.
    • Organizer
      MBO | EMBL Symposia 2012: Quality Control - From Molecules to Organelles
    • Place of Presentation
      Heiderberg, Germany
    • Related Report
      2012 Research-status Report
  • [Remarks] 大脳における抑制性の無髄神経線維束の発見

    • URL

      http://www.juntendo.ac.jp/graduate/pdf/news13.pdf

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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