Role of fatty acid elongase Elovl6 in the sucrose preference formation
| Project/Area Number |
24659441
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKA Takashi 筑波大学, 医学医療系, 准教授 (70400679)
NAKAGAWA Yoshimi 筑波大学, 医学医療系, 講師 (80361351)
石井 清朗 筑波大学, 医学医療系, 助教 (80419150)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 脂肪酸 / 嗜好性 / 食嗜好性 |
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| Research Abstract |
We investigated the effects of Elovl6 deficiency on the food intake and food preference in mice. Three types of diets were used in this study, with one or two diets simultaneously available to wild-type (WT) and Elovl6 knockout (KO) mice. In Experiment 1, mice were fed a standard chow, high fat, or high sucrose diet. In Experiment 2, WT and Elovl6KO mice were fed one of three pairs of diet, chow and HF, HS and HF, or chow and HS. Food intake was sequentially monitored in individually caged mice. In Experiment 1, Elovl6KO mice showed an enhanced ingestion of HS diet than WT mice. In contrast, the standard chow and HF diet intake were similar between WT and Elovl6KO mice. In Experiment 2, as compared with WT mice, Elovl6KO mice showed a greater preference for HS diet than a chow diet, but exhibited an equivalent preference for chow versus HF diet, or HS versus HF diet. With chow and HS diets, the total amount of food and calorie intake, which are the sum of HS and chow diet, were similar between WT and Elovl6 KO mice because chow diet consumption was decreased at all time point in Elovl6KO mice. Elovl6KO mice demonstrated a clear enhanced preference for HS diet. These results indicate that Elovl6 may play a specific and unique role in the control of hedonic eating such as sucrose palatability, but have no effect on homeostatic eating.
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Report
(2 results)
Research Products
(21 results)
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[Journal Article] TFE3 inhibits myoblast differentiation inC2C12 cells via down-regulating geneexpression of myogenin2013
Author(s)
Naka A, Iida KT, Nakagawa Y, IwasakiH, Takeuchi Y, Satoh A, Matsuzaka T, IshiiKA, Kobayashi K, Yatoh S, Shimada M, YahagiN, Suzuki H, Sone H, Yamada N, Shimano H
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Journal Title
Biochem BiophysRes Commun
Volume: 430(2)
Pages: 664-669
Related Report
Peer Reviewed
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[Journal Article] Elovl6 promotes nonalcoholic steatohepatitis2012
Author(s)
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A,Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H
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Journal Title
Hepatology
Volume: 56(6)
Pages: 2199-2208
Related Report
Peer Reviewed
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[Journal Article] Dicer hasa crucial role in the early stage ofadipocyte differentiation, but not inlipid synthesis, in 3T3-L1 cells2012
Author(s)
Fujimoto Y, Nakagawa Y, Shingyouchi A,Tokushige N, Nakanishi N, Satoh A,Matsuzaka T, Ishii KA, Iwasaki H,Kobayashi K, Yatoh S, Suzuki H, Yahagi N,Urayama O, Yamada N, Shimano H
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Journal Title
BiochemBiophys Res Commun
Volume: 420(4)
Pages: 931-936
Related Report
Peer Reviewed
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[Journal Article] regulates muscle metabolic geneexpression, increases glycogen stores,and enhances insulin sensitivity in mice.2012
Author(s)
Iwasaki H, Naka A, Iida KT, NakagawaY, Matsuzaka T, Ishii KA, Kobayashi K,Takahashi A, Yatoh S, Yahagi N, Sone H,Suzuki H, Yamada N, Shimano H
Volume
302(7)
Related Report
Peer Reviewed
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[Journal Article] Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.2012
Author(s)
Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H
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Journal Title
Biochem Biophys Res Commun
Volume: 420
Issue: 4
Pages: 931-6
DOI
Related Report
Peer Reviewed
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[Presentation] Deletion of Elovl6 protects against thefailure of pancreatic beta-cell mass andfunction in db/db mice2012
Author(s)
Yuta Nakano, Takashi Matsuzaka, NieTang, Marii Suzuki, Noriko Suzuki-Kemuriyama, Motoko Kuba, KeitaShoshi, Tomotaka Yokoo, Yoshimi Nakagawa,Kiyoaki Ishii, Masako Shimada, HitoshiIwasaki, Kazuto Kobayashi, Shigeru Yatoh,Akimitsu Takahashi, Naoya Yahagi, Hi
Organizer
第35回日本分子生物学会年会
Place of Presentation
マリンメッセ福岡、福岡
Year and Date
2012-12-11
Related Report
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[Presentation] Elovl6 promotesnonalcoholic steatohepatitis in mice andhumans2012
Author(s)
Takashi Matsuzaka, Tang Nie, NorikoSuzuki-Kemuriyama, Motoko Kuba, YoshimiNakagawa, Kiyoaki Ishii, Masako Shimada,Kazuto Kobayashi, Shigeru Yatoh, AkimitsuTakahashi, Hirohito Sone, Naoya Yahagi,Hiroaki Suzuki, Makoto Nakamuta, NobuhiroYamada, Hitoshi Shim
Organizer
9th IDF-WPR Congress and 4th AASDScientific Meeting
Place of Presentation
国立京都国際会館, 京都
Year and Date
2012-11-26
Related Report
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