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Role of fatty acid elongase Elovl6 in the sucrose preference formation

Research Project

Project/Area Number 24659441
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMANO Hitoshi  筑波大学, 医学医療系, 教授 (20251241)

Co-Investigator(Kenkyū-buntansha) MATSUZAKA Takashi  筑波大学, 医学医療系, 准教授 (70400679)
NAKAGAWA Yoshimi  筑波大学, 医学医療系, 講師 (80361351)
石井 清朗  筑波大学, 医学医療系, 助教 (80419150)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords脂肪酸 / 嗜好性 / 食嗜好性
Research Abstract

We investigated the effects of Elovl6 deficiency on the food intake and food preference in mice. Three types of diets were used in this study, with one or two diets simultaneously available to wild-type (WT) and Elovl6 knockout (KO) mice. In Experiment 1, mice were fed a standard chow, high fat, or high sucrose diet. In Experiment 2, WT and Elovl6KO mice were fed one of three pairs of diet, chow and HF, HS and HF, or chow and HS. Food intake was sequentially monitored in individually caged mice. In Experiment 1, Elovl6KO mice showed an enhanced ingestion of HS diet than WT mice. In contrast, the standard chow and HF diet intake were similar between WT and Elovl6KO mice. In Experiment 2, as compared with WT mice, Elovl6KO mice showed a greater preference for HS diet than a chow diet, but exhibited an equivalent preference for chow versus HF diet, or HS versus HF diet. With chow and HS diets, the total amount of food and calorie intake, which are the sum of HS and chow diet, were similar between WT and Elovl6 KO mice because chow diet consumption was decreased at all time point in Elovl6KO mice. Elovl6KO mice demonstrated a clear enhanced preference for HS diet. These results indicate that Elovl6 may play a specific and unique role in the control of hedonic eating such as sucrose palatability, but have no effect on homeostatic eating.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (21 results)

All 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (12 results) (of which Invited: 3 results) Remarks (2 results)

  • [Journal Article] TFE3 inhibits myoblast differentiation inC2C12 cells via down-regulating geneexpression of myogenin2013

    • Author(s)
      Naka A, Iida KT, Nakagawa Y, IwasakiH, Takeuchi Y, Satoh A, Matsuzaka T, IshiiKA, Kobayashi K, Yatoh S, Shimada M, YahagiN, Suzuki H, Sone H, Yamada N, Shimano H
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 430(2) Pages: 664-669

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TFE3 inhibits myoblast diffrentiation in C2C12 cells via down-regulating gene expression of myogenin.2013

    • Author(s)
      Naka A, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430 Issue: 2 Pages: 664-669

    • DOI

      10.1016/j.bbrc.2012.11.094

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elovl6 promotes nonalcoholic steatohepatitis2012

    • Author(s)
      Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A,Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H
    • Journal Title

      Hepatology

      Volume: 56(6) Pages: 2199-2208

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dicer hasa crucial role in the early stage ofadipocyte differentiation, but not inlipid synthesis, in 3T3-L1 cells2012

    • Author(s)
      Fujimoto Y, Nakagawa Y, Shingyouchi A,Tokushige N, Nakanishi N, Satoh A,Matsuzaka T, Ishii KA, Iwasaki H,Kobayashi K, Yatoh S, Suzuki H, Yahagi N,Urayama O, Yamada N, Shimano H
    • Journal Title

      BiochemBiophys Res Commun

      Volume: 420(4) Pages: 931-936

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] regulates muscle metabolic geneexpression, increases glycogen stores,and enhances insulin sensitivity in mice.2012

    • Author(s)
      Iwasaki H, Naka A, Iida KT, NakagawaY, Matsuzaka T, Ishii KA, Kobayashi K,Takahashi A, Yatoh S, Yahagi N, Sone H,Suzuki H, Yamada N, Shimano H
    • Volume
      302(7)
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elovl6 promotes nonalcoholic steatohepatitis2012

    • Author(s)
      Takashi Matsuzaka, et al
    • Journal Title

      Hepatology

      Volume: 56 Issue: 6 Pages: 2199-2208

    • DOI

      10.1002/hep.25932

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.2012

    • Author(s)
      Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Issue: 4 Pages: 931-6

    • DOI

      10.1016/j.bbrc.2012.03.110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] アディポサイエンスからみた動脈硬化性疾患予防の展望2013

    • Author(s)
      島野 仁
    • Organizer
      第13回動脈硬化教育フォーラム
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2013-02-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Deletion of Elovl6 protects against thefailure of pancreatic beta-cell mass andfunction in db/db mice2012

    • Author(s)
      Yuta Nakano, Takashi Matsuzaka, NieTang, Marii Suzuki, Noriko Suzuki-Kemuriyama, Motoko Kuba, KeitaShoshi, Tomotaka Yokoo, Yoshimi Nakagawa,Kiyoaki Ishii, Masako Shimada, HitoshiIwasaki, Kazuto Kobayashi, Shigeru Yatoh,Akimitsu Takahashi, Naoya Yahagi, Hi
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡、福岡
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Elovl6 promotesnonalcoholic steatohepatitis in mice andhumans2012

    • Author(s)
      Takashi Matsuzaka, Tang Nie, NorikoSuzuki-Kemuriyama, Motoko Kuba, YoshimiNakagawa, Kiyoaki Ishii, Masako Shimada,Kazuto Kobayashi, Shigeru Yatoh, AkimitsuTakahashi, Hirohito Sone, Naoya Yahagi,Hiroaki Suzuki, Makoto Nakamuta, NobuhiroYamada, Hitoshi Shim
    • Organizer
      9th IDF-WPR Congress and 4th AASDScientific Meeting
    • Place of Presentation
      国立京都国際会館, 京都
    • Year and Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病へのアプローチ:病態メカニズムオリエンテッド とエネルギー代謝ネットワーク的視点2012

    • Author(s)
      島野 仁
    • Organizer
      第1回日本くすりと糖尿病学会学術集会
    • Place of Presentation
      星薬科大学 本館メインホール・新星館
    • Year and Date
      2012-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージ泡沫化および動脈硬化における脂肪酸伸長酵素Elovl6の役割2012

    • Author(s)
      松坂 賢、齋藤 亮、唐澤 直義、松森 理恵、煙山 紀子、中川 嘉、石井 清朗、岩崎 仁、小林 和人、矢藤 繁、高橋 昭光、曽根 博仁、鈴木 浩明、矢作 直也、山田 信博、島野 仁
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂質の質に視点をおいた脂質代謝疾患治療戦略2012

    • Author(s)
      島野 仁
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] アディポサイエンスからみた動脈硬化性疾患予防の展望

    • Author(s)
      島野 仁
    • Organizer
      第13回動脈硬化教育フォーラム
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Deletion of Elovl6 protects against the failure of pancreatic beta-cell mass and function in db/db mice.

    • Author(s)
      Yuta Nakano
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elovl6 promotes nonalcoholic steatohepatitis in mice and humans.

    • Author(s)
      Takashi Matsuzaka
    • Organizer
      9th IDF-WPR Congress and 4th AASD Scientific Meeting
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病へのアプローチ:病態メカニズムオリエンテッド とエネルギー代謝ネットワーク的視点

    • Author(s)
      島野 仁
    • Organizer
      第1回日本くすりと糖尿病学会学術集会
    • Place of Presentation
      星薬科大学 本館メインホール・新星館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] マクロファージ泡沫化および動脈硬化における脂肪酸伸長酵素Elovl6の役割

    • Author(s)
      松坂 賢
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂質の質に視点をおいた脂質代謝疾患治療戦略

    • Author(s)
      島野 仁
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 筑波大学 内分泌代謝・糖尿病内科

    • URL

      http://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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