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Cell therapy of adipocytes derived from human iPS cells using cellcontainers and animal disease models

Research Project

Project/Area Number 24659444
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionKyoto University

Principal Investigator

HOSODA Kiminori  京都大学, 医学研究科, 教授 (40271598)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Kazutoshi  京都大学, iPS 細胞研究所, 講師 (80432326)
YAMASHITA Jun  京都大学, iPS 細胞研究所, 教授 (50335288)
NAKAO Kazuki  東京大学, 医学研究科, 准教授 (20217657)
EBIHARA Ken  京都大学, 医学研究科, 准教授 (70362514)
SONE Masakatsu  京都大学, 医学研究科, 講師 (40437207)
SAKURAI Hidetoshi  京都大学, iPS 細胞研究所, 講師 (80528745)
NOGUCHI Michio  京都大学, 医学研究科, 医員 (00432394)
Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords脂肪細胞 / iPS細胞 / 脂肪萎縮症 / 細胞治療 / ヌードマウス
Research Abstract

We investigated the function of adipocyte derived from human iPS and ES cells and the survival and maintenance of these cells after transplantation into nude mice. The adipocytes derived from human iPS and ES cells showed adipocyte function such as lipolysis, and survived at least 4 weeks after the transplantation. The adipogenic differentiation and transplantation system in vitro and in vivo is expected to be useful in the study of pathophysiology and to be applied for future cell therapy.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (11 results)

All 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy2012

    • Author(s)
      Aotani D, Nakao K, et al
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 97 Issue: 10 Pages: 3663-3671

    • DOI

      10.1210/jc.2012-1872

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin activates hepatic 5’ AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatt Li Yver in lipodystrophy by leptin2012

    • Author(s)
      Miyamoto L, Nakao K, et al
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 48 Pages: 40441-40447

    • DOI

      10.1074/jbc.m112.384545

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo2012

    • Author(s)
      Bando M, Nakao K, et al
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 302 Issue: 4 Pages: 403-408

    • DOI

      10.1152/ajpendo.00341.2011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function2012

    • Author(s)
      Odori S, Nakao K, et al
    • Journal Title

      Metabolism

      Volume: 62 Issue: 1 Pages: 70-78

    • DOI

      10.1016/j.metabol.2012.06.010

    • NAID

      120005242664

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation2012

    • Author(s)
      J.Fujikura, M.Sone, K.Hosoda, K.Nakao, et al
    • Journal Title

      Diabetologia

      Volume: (in press) Issue: 6 Pages: 1689-1698

    • DOI

      10.1007/s00125-012-2508-2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome:2012

    • Author(s)
      Nakao YM, Hosoda K, et al
    • Journal Title

      Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.

      Volume: 88(8) Pages: 454-461

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)

    • Author(s)
      Nakao YM, Hosoda K, et al.
    • Journal Title

      Ser B Phys Biol Sci.

      Volume: 88(8) Pages: 454-61

    • NAID

      130001924760

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ヒト ips 細胞由来の脂肪細胞の脂肪細胞機能解析と細胞移植2012

    • Author(s)
      野口倫生, 細田公則, 他.
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2012-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規のインスリン分泌促進因子 GPR40 の遺伝性肥満モデルの発現調節と機能的意義2012

    • Author(s)
      冨田努, 細田公則, 他
    • Organizer
      第109回日本内科学会
    • Place of Presentation
      みやこめっせ(京都府)
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトiPS細胞由来の脂肪細胞の脂肪細胞機能解析と細胞移植

    • Author(s)
      野口倫生、細田公則、田浦大輔、森栄作、松原正樹、曽根正勝、藤倉純二、海老原健、中尾一和
    • Organizer
      第109回日本内科学会
    • Place of Presentation
      みやこめっせ(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトiPS細胞由来脂肪細胞の分化誘導と細胞移植

    • Author(s)
      野口倫生、細田公則、森栄作、松原正樹、田浦大輔、曽根正勝、藤倉純二、海老原健、中尾一和
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都府)
    • Related Report
      2012 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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