Effect of thyroid hormone to muscle hypertrophy by aerobic training.

• Project/Area Number: 24659449
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: KOIBUCHI NORIYUKI 群馬大学, 医学(系)研究科(研究院), 教授 (80234681)
• Co-Investigator(Kenkyū-buntansha): IWASAKI Toshiharu 群馬大学, 大学院医学系研究科, 講師 (80375576)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 有酸素運動 / 骨格筋 / 甲状腺ホルモン / NaK-ATPase / ホルモン感受性

Research Abstract

Aerobic exercise facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. We studied whether TH signaling pathway is activated by aerobic training using rat treadmill exercise model. Male adult rats received 30 min/day treadmill training with different exercise intensity for 12 days. We determined exercize intensity by plasma lactate levels. TSH level was suppressed in both aerobic and anaerobic groups during the exercise. TRbeta1 mRNA and protein levels were augmented by aerobic but not anaerobic training. Aerobic training also augmented T3-activated NaK-ATPase mRNA expression. Aerobic training alters TH signaling at least in part by increasing TRbeta1 expression.

Research Products

• [Journal Article] Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism. (2014)
  • Author(s): Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Kasagi M, Masuda H, Jingu H, Furudate SI, Haijima A, Takatsuru Y, Iwasaki T, Umezu M, Koibuchi N.
  • Journal Title: J Neuroendocrinol. Volume: 26 Issue: 3 Pages: 164-175
  • DOI: 10.1111/jne.12135
  • Peer Reviewed / Open Access
• [Journal Article] Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. (2014)
  • Author(s): Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T.
  • Journal Title: J Neurochem. Volume: 128 Issue: 4 Pages: 507-522
  • DOI: 10.1111/jnc.12486
  • Peer Reviewed / Open Access
• [Journal Article] Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder (2014)
  • Author(s): Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara H, Shimoyama D, Takatsuru Y, Iwasaki T, Shimokawa N, Takagishi K, Koibuchi N
  • Journal Title: Physiological Rep Volume: 2 Issue: 1 Pages: 1-10
  • DOI: 10.1002/phy2.197
  • Peer Reviewed / Open Access
• [Journal Article] The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 Iodothyronine deiodinase activity in astrocytes (2013)
  • Author(s): Xu M, Iwasaki T, Shimokawa N, Sajdel- Sulkowska EM, Koibuchi N.
  • Journal Title: Endocrine J Volume: 60 Pages: 1221-1230
  • NAID: 130004770400
  • URL: https://www.jstage.jst.go.jp/article/endocrj/60/11/60_EJ13-0294/_pdf
  • Peer Reviewed
• [Journal Article] Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain; modeling the effect of maternal infection on the developing human CNS. (2013)
  • Author(s): Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM.
  • Journal Title: Cerebellum Volume: 12 Issue: 4 Pages: 572-586
  • DOI: 10.1007/s12311-013-0465-z
  • Peer Reviewed
• [Journal Article] The role of thyroid hormone on functional organization in the cerebellum (2013)
  • Author(s): Koibuchi N
  • Journal Title: Cerebellum Volume: 12 Issue: 3 Pages: 304-306
  • DOI: 10.1007/s12311-012-0437-8
  • Peer Reviewed
• [Journal Article] Activity of Layer II/III neurons in the somatosensory cortex (SCC) plays a critical role on the functional recovery after focal stroke in the contralateral SCC (2013)
  • Author(s): Takatsuru Y, Nabekura J, Koibuchi N.
  • Journal Title: Neuroscience Letter Volume: 543 Pages: 168-171
  • DOI: 10.1016/j.neulet.2013.03.049
  • Peer Reviewed
• [Journal Article] Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter (2013)
  • Author(s): Kazumi Hirooka-Masui
  • Journal Title: Life Sciences Volume: 92 Issue: 17-19 Pages: 911-915
  • DOI: 10.1016/j.lfs.2013.03.007
  • Peer Reviewed
• [Journal Article] Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke. (2013)
  • Author(s): Takatsuru Y, Eto K, Kaneko R, Masuda H, Shimokawa N, Koibuchi N, Nabekura J.
  • Journal Title: J Neurosci. Volume: 33 Issue: 11 Pages: 4683-4692
  • DOI: 10.1523/jneurosci.2657-12.2013
  • Peer Reviewed
• [Journal Article] Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor (2013)
  • Author(s): Akira Takeshita, Junko Igarashi-Migitaka, Noriyuki Koibuchi, Yasuhiro Takeuchi.
  • Journal Title: Journal of Endocrinology Volume: Vol.216 Issue: 3 Pages: 297-305
  • DOI: 10.1530/joe-12-0297
  • Peer Reviewed
• [Journal Article] 環境因子と甲状腺ホルモ ン受容体異常(転写共役因子含む) (2013)
  • Author(s): 鯉淵典之
  • Journal Title: カレントテ ラピー Volume: 31 Pages: 89-90
• [Journal Article] The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 Iodothyronine deiodinase activity in astrocytes. (2013)
  • Author(s): Xu M, Iwasaki T, Shimokawa N, Sajdel-Sulkowska EM, Koibuchi N.
  • Journal Title: Endocrine J. Volume: 60 Pages: 1221-1230
  • NAID: 130004770400
  • Peer Reviewed
• [Journal Article] Effects of perinatal lipopolysaccharide (LPS) exposure on the developing rat brain; modeling the effect of maternal infection on the developing human CNS. (2013)
  • Author(s): Xu M
  • Journal Title: Cerebellum Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Aberrant cerebellar neurotrophin-3 expression induced by lipopolysaccharide exposure during brain development. (2013)
  • Author(s): Xu M, Sajdel-Sulkowska EM, Iwasaki T, Koibuchi N.
  • Journal Title: Cerebellum Volume: 12 Issue: 3 Pages: 316-318
  • DOI: 10.1007/s12311-012-0446-7
  • Peer Reviewed
• [Journal Article] Lactational exposure to hydroxylated polychlorinated biphenyls (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor (2012)
  • Author(s): Lesmana R, Shimokawa N, Takatsuru Y, Iwasaki T, Koibuchi N.
  • Journal Title: Environ Toxicol
  • Peer Reviewed
• [Journal Article] Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion. (2012)
  • Author(s): Itoh M
  • Journal Title: Mol Cell Biochem. Volume: 373 Issue: 1-2 Pages: 11-18
  • DOI: 10.1007/s11010-012-1470-0
  • Peer Reviewed
• [Journal Article] 甲状腺ホルモン合成・分泌の分子機構 (2012)
  • Author(s): 鯉淵典之
  • Journal Title: 日本臨床 Volume: 70 Pages: 1844-1848
• [Journal Article] DE71 suppresses thyroid hormone-mediated dendritogenesis and neuritogenesis in the developing cerebellum (2012)
  • Author(s): Ibhazeheibo K, Koibuchi N.
  • Journal Title: Niger J Physiol Sci Volume: 27 Pages: 123-128
  • Peer Reviewed
• [Journal Article] An in vitro method to study the effects of thyroid hormone-disrupting chemicals on neuronal development. (2012)
  • Author(s): Xiong Y, Ibhazehiebo K, Iwasaki T, Koibuchi N.
  • Journal Title: Neurotoxicology. Volume: 33 Issue: 4 Pages: 753-757
  • DOI: 10.1016/j.neuro.2012.04.021
  • Peer Reviewed
• [Journal Article] Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor. (2012)
  • Author(s): Lesmana R
  • Journal Title: Environ Toxicol. Volume: Epub ahead of print Issue: 8 Pages: 9-16
  • DOI: 10.1002/tox.21815
  • Peer Reviewed
• [Presentation] How useful the animal models are to study the role of thyroid hormone on cerebellar development (2014)
  • Author(s): Koibuchi N.
  • Organizer: Inaugural Scientific Conference of the Sri Lanka Association for Laboratory Animal Science
  • Place of Presentation: Colombo, Sri Lanka
  • Year and Date: 2014-01-25
• [Presentation] 先天性甲状腺機能低下症マウス において、parallel fiber-Purkinje シナプスの短 期可塑性に異常がみられた (2014)
  • Author(s): 天野出月,高鶴祐介,戸谷秀太郎,はい島 旭,鯉淵典之
  • Organizer: 第91回日本生理学 会大会
  • Place of Presentation: 鹿児島
• [Presentation] ラット骨格筋における異なる強度のトレ ッドミル運動による甲状腺ホルモンシグナリングの変化 (2014)
  • Author(s): 岩崎俊晴,レスマナロニー,下川哲昭,鯉 淵典之
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] ラット骨格筋における異なる強度のトレッドミル運動による甲状腺ホルモンシグナリングの変化 (2014)
  • Author(s): 岩崎俊晴，Ronny Lesmana，下川哲昭，鯉淵典之
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 脳梗塞回復期の健常半球におけるアストロサイトの役割 シンポジウム「グリア病の薬理学」 (2014)
  • Author(s): 高鶴裕介，鍋倉淳一，鯉淵典之
  • Organizer: 第87回 日本薬理学会年会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 健常半球における脳梗塞後の機能代償に対するグルタミン酸トランスポーターの役割 (2014)
  • Author(s): 高鶴裕介，金子涼輔，小尾紀翔，下川昭哲，鍋倉純一，鯉淵典之
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 周産期の水酸化PCB曝露が成熟仔マウスの自発運動量へ及ぼす影響 (2014)
  • Author(s): はい島旭，下川哲昭，高鶴裕介，天野出月，レスマナロニー，鯉淵典之
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 先天性甲状腺機能低下症マウスにおいて，parallel fiber-Purkinje シナプスの短期可塑性に異常がみられた (2014)
  • Author(s): 天野出月，高鶴祐介，戸谷秀太郎，はい島旭，鯉淵典之
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] CIN85 はドパミン－プロラクチンシグナルを介して哺育行動を制御する (2014)
  • Author(s): 下川哲昭，西連寺拓，高梨ゆり絵，増田真之佑，鯉淵典之
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] Toxicology of environmental chemicals, especially PCBs – their interaction with thyroid hormone fuction and its impact on neurodevelopment (2013)
  • Author(s): Koibuchi N.
  • Organizer: Ruhr-University Cloloquium
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2013-07-08
  • Invited
• [Presentation] Thyroid hormone and cerebellar development (2013)
  • Author(s): Koibuchi N.
  • Organizer: Internatinal Gaduate School of Neuroscience Symposium "Impacts of thyroid hormone on the decelopment of the nervous system"
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2013-07-08
  • Invited
• [Presentation] Neurotoxic effects of environmental chemicals on cerebellar function (2013)
  • Author(s): Koibuchi N.
  • Organizer: The 10^<th> Biennial Conference of the Chinese Neuroscience Society
  • Place of Presentation: Beijing, China
  • Invited
• [Presentation] New challenge of Physiological Society of Japan – Reform of annual meeting and establishment of Physiology Educator role (2013)
  • Author(s): Koibuchi N, Nakashima A, Ishimatsu M, Okumura S, Okumura T, Kawai Y, Kuno M, Koizumi A, Shiibashi M, Suzuki A, Matsuda T, Morita H, Yamashita T, Yamanaka A.
  • Organizer: 37^<th> International Congress of Physiological Society
  • Place of Presentation: Birmingham, UK
• [Presentation] New challenge of Physiological Society of Japan – Reform of annual meeting and establishment of Physiology Educator role (2013)
  • Author(s): Koibuchi N, Nakashima A, Ishimatsu M, Okumura S, Okumura T, Kawai Y, Kuno M, Koizumi A, Shiibashi M, Suzuki A, Matsuda T, Morita H, Yamashita T, Yamanaka A.
  • Organizer: The IUPS and ADInstruments Teaching Workshop
  • Place of Presentation: Bristol, UK
• [Presentation] Hyperactivity of rat and mouse induced by lactational exposure to hydorxylated PCB (OH-PCB106) (2013)
  • Author(s): Koibuchi N, Haijima A, Lesmana R, Amano I, Takatsuru Y, Iwasaki T, Shimokawa N.
  • Organizer: 52th annual Meeting and ToxExpo, Society of Toxicology
  • Place of Presentation: San Antonio, USA
• [Presentation] 新たな機序によ る Perfluorooctane Sulfonate (PFOS)の脳発達ヘ の影響 (2013)
  • Author(s): 岩崎俊晴,はい島旭,宮坂勇平,Yu Lu,高 鶴裕介,下川哲昭,鯉淵典之
  • Organizer: 環境ホルモン学会第16回研究発表会
  • Place of Presentation: 東京
• [Presentation] ラット骨格筋における有酸素運動の甲 状腺ホルモン制御系に与える影響 (2013)
  • Author(s): 岩崎俊晴,Ronny Lesmana,下川哲昭,鯉 淵典之
  • Organizer: 第86回日 本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] ラット vivo モデルを用いた,骨吸収抑制剤がビ タミン D 代謝に及ぼす影響の検討 (2013)
  • Author(s): 竹下彰,五十嵐潤子,鯉淵典之,竹内靖博
  • Organizer: 第86回日 本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] アストロサイトにおける甲状腺ホルモン制御機構に対するリポポリサッカリドの影響 (2013)
  • Author(s): 岩崎俊晴,徐明,下川哲昭,鯉淵典之
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] ラット骨格筋における有酸素運動の甲状腺ホルモン制御系に与える影響 (2013)
  • Author(s): 岩崎俊晴，Ronny Lesmana，下川哲昭，鯉淵典之
  • Organizer: 第86回 日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] Neurotoxic effects of environmental chemicals on cerebellar function. (2013)
  • Author(s): Koibuchi N.
  • Organizer: The 10th Biennial Conference of the Chinese Neuroscience Society.
  • Place of Presentation: Beijing, China.
  • Invited
• [Presentation] 新たな機序によるPerfluorooctane Sulfonate (PFOS)の脳発達ヘの影響 (2013)
  • Author(s): 岩崎俊晴，はい島旭，宮坂勇平，Yu Lu，高鶴裕介，下川哲昭，鯉淵典之
  • Organizer: 環境ホルモン学会 第16回研究発表会
  • Place of Presentation: 東京
• [Presentation] 周産期の水酸化PCB曝露が成熟仔マウスの自発運動量へ及ぼす影響 (2013)
  • Author(s): はい島旭，下川哲昭，高鶴裕介，天野出月，レスマナロニー，鯉淵典之
  • Organizer: 環境ホルモン学会 第16回研究発表会
  • Place of Presentation: 東京
• [Presentation] プルキンエ細胞に変異甲状腺ホルモン受容体を発現するトランスジェニックマウスの小脳発達に対する影響 （YIA候補演題） (2013)
  • Author(s): Yu Lu，岩崎俊晴，鯉淵典之
  • Organizer: 第56回 日本甲状腺学会
  • Place of Presentation: 和歌山
• [Presentation] 甲状腺ホルモン受容体を介する脳発達に及ぼすPCB, PBDE, およびPFOSの影響 (2013)
  • Author(s): 鯉淵典之
  • Organizer: フォーラム2013 衛生薬学・環境トキシコロジー
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 胎仔期・授乳期の低用量水酸化PCB曝露が成熟後仔マウスへ及ぼす影響 (2013)
  • Author(s): はい島旭，下川哲昭，高鶴裕介，天野出月，レスマナロニー，鯉淵典之
  • Organizer: 第40回 日本毒性学会学術年会
  • Place of Presentation: 幕張
• [Presentation] ラットvivoモデルを用いた，骨吸収抑制剤がビタミンD代謝に及ぼす影響の検討 (2013)
  • Author(s): 竹下彰，五十嵐潤子，鯉淵典之，竹内靖博
  • Organizer: 第86回 日本内分泌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] The opposite effects of lipopolysaccharide to thyroxine on thyroid hormone-regulated functions in astrocyte. (2013)
  • Author(s): Toshiharu Iwasaki
  • Organizer: 第90回 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] The effect of perfluorooctane (PFOS) and perfluorooctanoic acid (PFOA) on primary culture of rat cerebellum. (2013)
  • Author(s): Yuhei Miyasaka
  • Organizer: 第90回 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] Effect of thyroid hormone for cerebellar development～analysis of transgenic mice that specifically express mutant thyroid hormone receptor in Purkinje cells. (2013)
  • Author(s): Lu Yu
  • Organizer: 第90回 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] Possible Involvement of Brain-Derived Repressive Molecule (B-ReM) in Normal Cerebellar Development. (2013)
  • Author(s): Yu Xiong
  • Organizer: 第90回 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] The effect of thyroid hormone status on behavioral alteration during development and exercise training (2012)
  • Author(s): Koibuchi N.
  • Organizer: Cardiovascular and Metabolic Disease Seminar, Duke-NUS
  • Place of Presentation: Singapore
  • Year and Date: 2012-09-04
• [Presentation] Aberrant cerebellar development in dual oxidase maturation factor (DUOXA) knockout mice (2012)
  • Author(s): Amano I, Takatsuru Y, Haijima A, Koibuchi N.
  • Organizer: 10^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: Bali, Indonesia
• [Presentation] Aerobic training (AT) influences plasma concentration of thyroid hormone and potentiates thyroid hormone (TH) responsiveness to several genes in rat skeletal muscle (2012)
  • Author(s): Lesmana R, Iwasaki T, Shimokawa N, Koibuchi N.
  • Organizer: 10^<th> Asia and Oceania Thyroid Association Congress
  • Place of Presentation: Bali, Indonesia
• [Presentation] Abnormal cerebellar neurotrophin expression in autism patients and LPS-treated rat model (2012)
  • Author(s): Xu M, Iwasaki T, Sajdel-Sulkowska E, Shimokawa N, Koibuchi N.
  • Organizer: 55^<th> Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe, Japan
• [Presentation] Abnormal cerebellar neurotrophin expression in autism patients and LPS-treated rat model (2012)
  • Author(s): Xu M, Iwasaki T, Shimokawa N, Koibuchi N.
  • Organizer: 5^<th> Annual Meeting of the Society for Research on the Cerebellum
  • Place of Presentation: Hangzhou, China
• [Presentation] The role of thyroid hormone on functional organization in the cerebellum (2012)
  • Author(s): Koibuchi N.
  • Organizer: 5^<th> Annual Meeting of the Society for Research on the Cerebellum
  • Place of Presentation: Hangzhou, China
  • Invited
• [Presentation] The effect of perinatal hypothyroidism on neuronal development and plasticity (2012)
  • Author(s): Koibuchi N.
  • Organizer: International Neuroscience Symposium 2012
  • Place of Presentation: Kota Kinabaru, Malaysia
  • Invited
• [Presentation] Congenital hypothyroidism causes behavioral disorders by impaired cerebellar function and aberrant axonal transport of dopamine (2012)
  • Author(s): Koibuchi N, Iwasaki T, Takatsuru Y, Umezu M, Shimokawa N.
  • Organizer: 8^<th> Federation of European Neuroscience Societies Forum of Neuroscience
  • Place of Presentation: Barcelona, Spain
• [Presentation] Synaptic instability is induced by maternal separation in somatosensory cortex (2012)
  • Author(s): Takatsuru Y, Toya S-T, Nabekura J, Koibuchi N.
  • Organizer: 8^<th> Federation of European Neuroscience Societies
  • Place of Presentation: Barcelona, Spain
• [Presentation] Perfluorooctane sulfonate (PFOS)とPerfluorooctanoic acid (PFOA)による脳発達に 与える影響 (2012)
  • Author(s): 岩崎俊晴,宮坂勇平,原口瑞樹,Ronny Lesmana, はい島旭,下川哲昭,鯉淵典之
  • Organizer: 環境ホルモン学会第15回研究発 表会
  • Place of Presentation: 東京
• [Presentation] 甲状腺ホルモン受容体を介する転写における Arnt および AhR の関与 (2012)
  • Author(s): 宮崎航,岩崎俊晴,加藤貴彦,鯉淵典之
  • Organizer: 環境ホルモン学会第15回研究発表会
  • Place of Presentation: 東京
• [Presentation] アストロサイトにおける甲状腺ホルモンおよびリポ多糖(LPS)の影響 (2012)
  • Author(s): 岩崎俊晴,徐明,下川哲昭,Sadel-Sulkowska EM,鯉淵典之
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Perfluorooctane sulfonate (PFOS)とPerfluorooctanoic acid (PFOA)による脳発達による脳発達に与える影響． (2012)
  • Author(s): 岩崎俊晴
  • Organizer: 第15回 環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] 甲状腺ホルモン受容体を介する転写におけるArntおよびAhRの関与 (2012)
  • Author(s): 宮崎 航
  • Organizer: 第15回 環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] 甲状腺機能低下モデル動物を用いた甲状腺ホルモンの脳発達への影響，特に甲状腺機能と行動異常の関係についての解析 (2012)
  • Author(s): 岩崎俊晴
  • Organizer: 第55回 日本甲状腺学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Aerobic exercise influences plasma concentration of thyroid hormone and potentiates thyroid hormone (TH) responsiveness to several genes in rat skeletal muscle. (2012)
  • Author(s): Ronny Lesmana
  • Organizer: 10th Asia and Oceania Thyroid Association Congress.
  • Place of Presentation: Bali, Indonesia
• [Presentation] The role of thyroid hormone on functional organization in the cerebellum (2012)
  • Author(s): Noriyuki Koibuchi
  • Organizer: 5th Annual Meeting of the Society for Research on the Cerebellum
  • Place of Presentation: Hangzhou, China
  • Invited
• [Presentation] Abnormal cerebellar neuroyrophin expression in autism patients and LPS-treated rat model. (2012)
  • Author(s): Xu M
  • Organizer: 5th Annual Meeting of the Society for Research on the Cerebellum
  • Place of Presentation: Hangzhou, China
• [Presentation] The effect of lipopolysaccharide on thyroid hormone-regulated functions of astrocyte. (2012)
  • Author(s): Toshiharu Iwasaki
  • Organizer: 第35回 日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Aberrant cerebellar development of the transgenic mouse expressing a dominant-negative thyroid hormone receptor in Purkinje cell. (2012)
  • Author(s): Lu Yu
  • Organizer: 第35回 日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] The effect of perinatal hypothyroidism on neuronal development and plasticity. (2012)
  • Author(s): Noriyuki Koibuchi
  • Organizer: International Neuroscience Symposium
  • Place of Presentation: Kota, Malaysia
  • Invited
• [Presentation] Congenital hypothyroidism caused behavioral disorders by impaired cerebellar function and aberrant axonal transport of dopamine. (2012)
  • Author(s): Noriyuki Koibuchi
  • Organizer: 8 th Federatio of European Neuroscience Societies Forum of Neuroscience
  • Place of Presentation: Barcelona, Spain
• [Presentation] アストロサイトにおけるアクチン重合化及びD2活性に対するリポ多糖(LPS)の影響 (2012)
  • Author(s): 岩崎俊晴
  • Organizer: 第30回 内分泌学サマーセミナー
  • Place of Presentation: 伊香保
• [Presentation] Effect of aerobic exercize on thyroid hormone-related signaling. (2012)
  • Author(s): Ronny Lesmana
  • Organizer: 第30回 内分泌学サマーセミナー
  • Place of Presentation: 伊香保
• [Presentation] アストロサイトにおける甲状腺ホルモン及びリポ多糖(LPS)の影響 (2012)
  • Author(s): 岩崎俊晴
  • Organizer: 第85回 日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ラット骨格筋における有酸素運動による甲状腺ホルモンシグナル系の変化
  • Author(s): 岩崎俊晴，Ronny Lesmana, 下川哲昭，鯉淵典之
  • Organizer: 第91回 日本生理学会大会サテライト企画 第40回環境生理グループプレコングレス
  • Place of Presentation: 鹿児島
• [Presentation] Thyroid hormone and cerebellar development.
  • Author(s): Koibuchi N.
  • Organizer: Internatinal Gaduate School of Neuroscience Symposium “Impacts of thyroid hormone on the decelopment of the nervous system”.
  • Place of Presentation: Bochum, Germany.
  • Invited
• [Presentation] 多動性に関わる内分泌系因子の同定とかく乱物質の影響に関する研究
  • Author(s): 鯉淵典之
  • Organizer: 平成25年環境省度化学物質の内分泌かく乱作用に関する公開セミナー
  • Place of Presentation: 東京
  • Invited
• [Book] Gender Difference in Prenatal Substance Exposure. (2012)
  • Author(s): Sajdel-Sulkowska EM, Koibuchi N
  • Total Pages: 227
  • Publisher: American Psychological Association
• [Remarks] 群馬大学医学系研究科 応用生理学分野
  • URL: http://nori3.dept.med.gunma-u.ac.jp/