Concept of Physiologic Inflammation and Its Functional Significance

• Project/Area Number: 24659450
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OGAWA Yoshihiro 東條医科歯科大学, 大学院・医歯学総合研究科, 教授 (70291424)
• Project Period (FY): 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 内分泌学 / 生理的炎症 / 病的炎症 / マクロファージ / 妊娠 / 脂肪分解

Research Abstract

The data of this study suggest that pro-inflammatory M1 macrophages infiltrated into adipose tissue of pregnant mice induce insulin resistance via increased adipocyte lipolysis, thereby resulting in stable supply of energy to fetus. Our data also suggest that transient and reversible physiologic inflammation of adipose tissue in pregnant mice plays an important role in homeostasis both dam and fetus.

Research Products

• [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2012)
  • Author(s): Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y
  • Journal Title: Diabetes Volume: 61 Pages: 1199-1209
• [Journal Article] Highly purified eicosapentaenoic acid increasesinterleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia (2012)
  • Author(s): Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Hasegawa K, Ogawa Y
  • Journal Title: Diabetes Care Volume: 35 Pages: 2631-2639
• [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation (2012)
  • Author(s): Suganami T, Tanaka M, Ogawa Y
  • Journal Title: Endocr. J Volume: 59 Pages: 849-857
  • NAID: 10031123130
• [Journal Article] Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia (2012)
  • Author(s): N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H. Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa
  • Journal Title: Diabetes Care Volume: 35 Issue: 12 Pages: 2631-2639
  • DOI: 10.2337/dc12-0269
  • Peer Reviewed
• [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation (2012)
  • Author(s): Suganami T
  • Journal Title: Endocr. J. Volume: 59 Pages: 849-857
  • Peer Reviewed
• [Presentation] Chronic Inflammation and Ectopic Fat Accumulation in the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: The 2012 Spring Conference of the Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea
• [Presentation] Chronic Inflammation and Ectopic Fat Accumulation in the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y, Suganami T
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: Tokyo
• [Presentation] Adipose Tissue Remodeling as Homeostatic Inflammation (2012)
  • Author(s): Ogawa Y
  • Organizer: The 12th Biennial International Endotoxin &Innate Immunity Society (IEIIS) meeting, The Homeostatic Inflammation International Symposium
  • Place of Presentation: Tokyo
• [Presentation] Chronic Inflammation, AMolecular Basis Underlying the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: 2012 Shanghai Symposium on Obesity & Diabetes
  • Place of Presentation: Shanghai, China
• [Presentation] Adipose Tissue Inflammation and Ectopic Fat Accumulation (2012)
  • Author(s): Suganami T, Ogawa Y
  • Organizer: 2nd International Symposium for the Study of Obesity
  • Place of Presentation: Kyoto
• [Presentation] Chronic Inflammation and Ectopic Fat Accumulation in the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: 東京
  • Invited
• [Presentation] Adipose Tissue Remodeling as Homeostatic Inflammation (2012)
  • Author(s): Ogawa Y
  • Organizer: The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) meeting, The Homeostatic Inflammation International Symposium
  • Place of Presentation: 東京
  • Invited
• [Presentation] Chronic Inflammation, A Molecular Basis Underlying the Metabolic Syndrome (2012)
  • Author(s): Ogawa Y
  • Organizer: 2012 Shanghai Symposium on Obesity & Diabetes
  • Place of Presentation: Shanghai, China
  • Invited
• [Presentation] Adipose Tissue Inflammation and Ectopic Fat Accumulation (2012)
  • Author(s): Suganami T
  • Organizer: 2nd International Symposium for the Study of Obesity
  • Place of Presentation: 京都
  • Invited
• [Book] 日本人だから知っておきたい「異所性脂肪」の恐怖 (2012)
  • Author(s): 小川佳宏
  • Publisher: ワニブックス
• [Remarks]
  • URL: http://www.tmd.ac.jp/grad/cme/index.html
• [Remarks] 東京医科歯科大学大学院医歯学総合研究科分子内分泌代謝学分野
  • URL: http://www.tmd.ac.jp/grad/cme/index.html