Concept of Physiologic Inflammation and Its Functional Significance
Project/Area Number |
24659450
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
OGAWA Yoshihiro 東條医科歯科大学, 大学院・医歯学総合研究科, 教授 (70291424)
|
Project Period (FY) |
2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | 内分泌学 / 生理的炎症 / 病的炎症 / マクロファージ / 妊娠 / 脂肪分解 |
Research Abstract |
The data of this study suggest that pro-inflammatory M1 macrophages infiltrated into adipose tissue of pregnant mice induce insulin resistance via increased adipocyte lipolysis, thereby resulting in stable supply of energy to fetus. Our data also suggest that transient and reversible physiologic inflammation of adipose tissue in pregnant mice plays an important role in homeostasis both dam and fetus.
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Report
(2 results)
Research Products
(17 results)
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[Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012
Author(s)
Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y
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Journal Title
Diabetes
Volume: 61
Pages: 1199-1209
Related Report
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[Journal Article] Highly purified eicosapentaenoic acid increasesinterleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia2012
Author(s)
Satoh-Asahara N, Shimatsu A, Sasaki Y, Nakaoka H, Himeno A, Tochiya M, Kono S, Takaya T, Ono K, Wada H, Suganami T, Hasegawa K, Ogawa Y
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Journal Title
Diabetes Care
Volume: 35
Pages: 2631-2639
Related Report
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[Journal Article] Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia2012
Author(s)
N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H. Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa
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Journal Title
Diabetes Care
Volume: 35
Issue: 12
Pages: 2631-2639
DOI
Related Report
Peer Reviewed
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