Research Project
Grant-in-Aid for Challenging Exploratory Research
Brown adipose tissue (BAT) plays important roles in adaptive thermogenesis. It is well known that function of BAT is regulated by sympathetic nerve system and thyroid hormones. We have established animal models deficient in glucagon gene and have shown that glucagon plays important roles not only in glucose homeostasis but also in regulation of amino acid metabolism and nicotinamide metabolism.In this study, BAT function in glucagon-deficient mice was analyzed, as the animal showed cold intolerance. Expression of genes involved in thermogenesis, such as uncoupling protein 1 and deiodinase 2, was lower in BAT in glucagon-deficient mice than in the controls. Administration of glucagon to glucagon-deficient mice restored gene expression patterns in BAT and ameliorated cold intolerance. Involvement of FGF21 was suggested, as its serum concentration was markedly increased by glucagon administration.
All 2016 2015 2014 2013 2012
All Journal Article (18 results) (of which Peer Reviewed: 13 results, Open Access: 5 results, Acknowledgement Compliant: 3 results) Presentation (25 results) (of which Int'l Joint Research: 1 results, Invited: 16 results)
Journal of the American Society of Nephrology
Volume: 27 Issue: 3 Pages: 766-780
10.1681/asn.2014121196
日本臨床
Volume: 74(増1) Pages: 68-71
PLoS One
Volume: 10 Issue: 7 Pages: e0133812-e0133812
10.1371/journal.pone.0133812
Volume: 10 Issue: 9 Pages: e0138322-e0138322
10.1371/journal.pone.0138322
実験医学
Volume: 33(6) Pages: 897-902
Islet Equality
Volume: 4(3) Pages: 20-22
Am J Physiol Endocrinol Metab
Volume: 308 Issue: 7 Pages: 583-591
10.1152/ajpendo.00543.2014
J Endocrinol
Volume: 222 Issue: 2 Pages: 191-200
10.1530/joe-14-0161
Endocrinology
Volume: 155 Issue: 9 Pages: 3484-3492
10.1210/en.2014-1175
Volume: 9 Issue: 12 Pages: e116252-e116252
10.1371/journal.pone.0116252
Volume: 56 Issue: 2 Pages: 647-659
10.1210/en.2014-1741
Journal of Diabetes Investigation
Volume: 5(1) Issue: 1 Pages: 31-37
10.1111/jdi.12129
PLoS ONE
Volume: 8 Issue: 5 Pages: e64415-e64415
10.1371/journal.pone.0064415
Journal of Clinical Endocrinology and Metabolism
Volume: 98(7) Issue: 7 Pages: 2656-62
10.1210/jc.2013-2135
Diabetes Frontier
Volume: 5(24) Pages: 550-554
Diabetes
Volume: 62 Issue: 2 Pages: 510-518
10.2337/db12-0294
Plos One
Volume: 7(8) Issue: 8 Pages: e43745-e43745
10.1371/journal.pone.0043745
Diabetes Journal:糖尿病と代謝
Volume: 40(3) Pages: 1-8