Crosstalk between sirtuins and endocrine system in regulation of brown adipose tissue function.
| Project/Area Number |
24659451
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | グルカゴン / 褐色脂肪 / 熱産生 / 脱共役蛋白質 / 交感神経 / サーチュイン / ニコチンアミド代謝 / 線維芽細胞成長因子21 / 寒冷曝露 / ニコチンアミド / 甲状腺ホルモン / 寒冷暴露 / 内分泌代謝学 / カロリー制限 / 肥満 |
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| Outline of Final Research Achievements |
Brown adipose tissue (BAT) plays important roles in adaptive thermogenesis. It is well known that function of BAT is regulated by sympathetic nerve system and thyroid hormones. We have established animal models deficient in glucagon gene and have shown that glucagon plays important roles not only in glucose homeostasis but also in regulation of amino acid metabolism and nicotinamide metabolism.
In this study, BAT function in glucagon-deficient mice was analyzed, as the animal showed cold intolerance. Expression of genes involved in thermogenesis, such as uncoupling protein 1 and deiodinase 2, was lower in BAT in glucagon-deficient mice than in the controls. Administration of glucagon to glucagon-deficient mice restored gene expression patterns in BAT and ameliorated cold intolerance. Involvement of FGF21 was suggested, as its serum concentration was markedly increased by glucagon administration.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Chronic hyponatremia causes neurologic and psychologic impairments2016
Author(s)
Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y
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Journal Title
Journal of the American Society of Nephrology
Volume: 27
Issue: 3
Pages: 766-780
DOI
Related Report
Peer Reviewed
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[Journal Article] Fatty acid binding protein 5 (FABP5) regulates diet-induced obesity (DIO) via GIP secretion from enteroendocrine K-cells in response to fat ingestion.2015
Author(s)
Shibue, K., Yamane, S., Harada, N., Hamasaki, A., Suzuki, K., Joo, E., Iwasaki, K., Nasteska, D., Harada, T., Hayashi, Y., Adachi, Y., Owada, Y., Takayanagi, R. and Inagaki, N.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 308
Issue: 7
Pages: 583-591
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state2014
Author(s)
Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y
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Journal Title
J Endocrinol
Volume: 222
Issue: 2
Pages: 191-200
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression.2014
Author(s)
K. Ikegami, Y. Atsumi, E. Yorinaga, H. Ono, I. Murayama1, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida and T. Yoshimura
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Journal Title
Endocrinology
Volume: 56
Issue: 2
Pages: 647-659
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor deficient mice.2014
Author(s)
Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekaw S, Hayashi Y, Harada N, Yamada Y, Inagarki N, Seino Y, Oiso Y, Nakamura J
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Journal Title
Journal of Diabetes Investigation
Volume: 5(1)
Issue: 1
Pages: 31-37
DOI
Related Report
Peer Reviewed
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[Journal Article] Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides.2013
Author(s)
Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, Himeno T, Takagishi Y, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y.
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Journal Title
Diabetes
Volume: 62
Issue: 2
Pages: 510-518
DOI
Related Report
Peer Reviewed
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