Systematic survey for biologically active peptides in pheochromocytoma tissue.
| Project/Area Number |
24659452
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWASAKO Kenji 宮崎大学, フロンティア科学実験総合センター, 准教授 (20381098)
NAGATA Sayaka 宮崎大学, 医学部, 特任助教 (00452920)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 褐色細胞腫 / 受容体 / 新規生理活性ペプチド / cAMP / アミド化 / 血管作動性物質 / Big angiotensin-25 / ラジオイムノアッセイ / Big angiotensin-25 / アンジオテンシン |
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| Outline of Final Research Achievements |
We have performed the systematic survey for biologically active peptides in human pheochromocytoma tissue, using assay systems which we had originally established. We have purified and determined more than 50 peptides from human pheochromocytoma tissue. We discovered Big angiotensin-25 from human urine as an endogenous peptide. Further we have developed the assay system for Big angiotensin-25.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Inhibition of development of abdominal aortic aneurysm by glycolysis restriction.2012
Author(s)
Tsuruda T, Hatakeyama K, Nagamachi S, Sekita Y, Sakamoto S, Endo GJ, Nishimura M, Matsuyama M, Yoshimura K, Sato Y, Onitsuka T, Imamura T, Asada Y, and Kitamura K.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 1410-1417
Related Report
Peer Reviewed
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