Application of the novel intestinal hormone, IBCAP targeted pancreas beta-cell regeneration therapy.
| Project/Area Number |
24659453
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Yasushi 埼玉医科大学, 医学部, 教授 (80280733)
TOYOSHIMA Hideo 埼玉医科大学, 医学部, 客員准教授 (20197966)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 |
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| Research Abstract |
IBCAP (intestine derived beta-cell augmenting promoter) is another intestine-specific secretory protein with incretin-like activity, identified in our laboratory. IBCAP have pancreatic beta-cell proliferation activity in vitro. And, insulin positive cells were demonstrated in the liver of STZ treated type 1 diabetes model mice infected with IBCAP expressing adenovirus. Our results indicate that IBCAP could have an activity to induce not only proliferation but also differentiation of beta-cells. IBCAP may be used as a potent inducer for pancreatic beta-cell regeneration.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver2012
Author(s)
Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Kawakami M, Yamada N, Okazaki Y, Toyoshima H
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Journal Title
Diabetologia
Volume: 55(Suppl1)
Issue: S1
Pages: 1-538
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver.2012
Author(s)
Tomotaka YOKOO, Kazuhisa WATANABE, Kaoruko Tada IIDA, Hiroaki SUZUKI, Hitoshi SHIMANO, Masanobu KAWAKAMI, Nobuhiro YAMADA, Yasushi OKAZAKI, Hideo TOYOSHIMA
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Journal Title
Diabetologia
Volume: 55 Suppl 1
Related Report
Peer Reviewed
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[Presentation] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver2012
Author(s)
Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Kawakami M, Yamada N, Okazaki Y, Toyoshima H.
Organizer
48th EASD Annual Meeting
Place of Presentation
Berlin, Germany
Year and Date
2012-10-02
Related Report
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[Presentation] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver.2012
Author(s)
Tomotaka YOKOO, Kazuhisa WATANABE, Kaoruko Tada IIDA, Hiroaki SUZUKI, Hitoshi SHIMANO, Masanobu KAWAKAMI, Nobuhiro YAMADA, Yasushi OKAZAKI, Hideo TOYOSHIMA
Organizer
第48回 欧州糖尿病学会議 (EASD)
Place of Presentation
Messe Berlin（ドイツ、ベルリン）
Related Report
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