| Project/Area Number |
24659453
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Yasushi 埼玉医科大学, 医学部, 教授 (80280733)
TOYOSHIMA Hideo 埼玉医科大学, 医学部, 客員准教授 (20197966)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 糖尿病 |
|---|
| Research Abstract |
IBCAP (intestine derived beta-cell augmenting promoter) is another intestine-specific secretory protein with incretin-like activity, identified in our laboratory. IBCAP have pancreatic beta-cell proliferation activity in vitro. And, insulin positive cells were demonstrated in the liver of STZ treated type 1 diabetes model mice infected with IBCAP expressing adenovirus. Our results indicate that IBCAP could have an activity to induce not only proliferation but also differentiation of beta-cells. IBCAP may be used as a potent inducer for pancreatic beta-cell regeneration.
|
