Dual Stem Cell Therapy with Pharmacologically-Stimulated Mesenchymal Stem Cells

• Project/Area Number: 24659461
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: MAEKAWA TAIRA 京都大学, 医学(系)研究科(研究院), 教授 (80229286)
• Co-Investigator(Kenkyū-buntansha): MIURA Yasuo 京都大学, 大学院医学研究科, 助教 (70605146) ; HIRAI Hideyo 京都大学, 大学院医学研究科, 助教 (50315933)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 間葉系幹細胞 / さい帯血 / 副甲状腺ホルモン / 造血幹細胞 / テリパラチド / カドヘリン

Research Abstract

This study has examined potential of mesenchymal stem cells that are stimulated by pharmacological agents for the application to hematopoietic stem cell transplantation. Parathyroid hormone improved the survival of lethally-irradiated mice in bone marrow transplantation and stimulated mesenchymal stem cells to enhance the expansion of hematopoietic cells. Mesenchymal stem cells can be isolated from an umbilical cord blood unit with small volume that is unavailable for umbilical cord blood transplantation. The isolated umbilical cord blood mesenchymal stem cells showed the proliferation and multi-differentiation capabilities that are equivalent to bone marrow mesenchymal stem cells.

Research Products

• [Journal Article] CCR1-mediated Accumulation of Myeloid Cells in the Liver Microenvironment Promoting Mouse Colon Cancer Metastasis (2014)
  • Author(s): Hirai H, et al
  • Journal Title: Clinical and Experimental Metastasis Volume: 32 Issue: 8 Pages: 2245-55
  • DOI: 10.1002/stem.1701
  • Peer Reviewed / Open Access
• [Journal Article] CCAAT/Enhancer-Binding Protein β Expressed by Bone Marrow Mesenchymal Stromal Cells Regulates Early B-Cell Lymphopoiesis (2014)
  • Author(s): Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A, Maekawa T
  • Journal Title: Stem Cells Volume: 32 Issue: 3 Pages: 730-740
  • DOI: 10.1002/stem.1555
  • Peer Reviewed
• [Journal Article] Allogeneic stem cell transplantation for patients with acute myeloid leukemia developing from severe congenital neutropenia. (2014)
  • Author(s): Ebihara Y, Ishikawa K, Mochizuki S, Tanaka R, Manabe A, Iseki T, Maekawa T, Tsuji K.
  • Journal Title: Br J Haematol. Volume: 164 Issue: 3 Pages: 451-464
  • DOI: 10.1111/bjh.12638
  • Peer Reviewed / Open Access
• [Journal Article] HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. (2014)
  • Author(s): Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T
  • Journal Title: Haematologica Volume: 99(1) Issue: 1 Pages: 19-27
  • DOI: 10.3324/haematol.2013.083873
  • Peer Reviewed / Open Access
• [Journal Article] A Clinical, Pathological and Genetic Characterization of Methotrexate-Associated Lymphoproliferative Disorders. (2014)
  • Author(s): Yamakawa N, Fujimoto M, Kawabata D, Terao C, Nakashima R, Imura Y, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Yurugi K, Miura Y, Maekawa T, Saji H, Matsuda F, Haga H, Mimori T
  • Journal Title: J Rheumatol Volume: 41 Issue: 2 Pages: 293-299
  • DOI: 10.3899/jrheum.130270
  • Peer Reviewed
• [Journal Article] Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ in combination with nilotinib against BCR-ABL-positive leukemia cells involves the ABL kinase domain mutation. (2014)
  • Author(s): Okabe S, Tauchi T, Tanaka Y, Kitahara T, Kimura S, Maekawa T, Ohyashiki K
  • Journal Title: Cancer Biol Ther Volume: 15 Issue: 2 Pages: 207-215
  • DOI: 10.4161/cbt.26725
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers (2014)
  • Author(s): Morimoto N, Ito T, Takemoto S, Katakami M, Kanda N, Tada H, Tanaka S, Teramukai S, Kawai K, Nakamura Y, Kasai Y, Yokode M, Maekawa T, Shimizu A, Suzuki S
  • Journal Title: International Wound Journal Volume: 11 Issue: 2 Pages: 183-189
  • DOI: 10.1111/j.1742-481x.2012.01064.x
  • Peer Reviewed
• [Journal Article] Chimerism of bone marrow mesenchymal stem/stromal cells in allogeneic hematopoietic cell transplantation: is it clinically relevant? (2013)
  • Author(s): Miura Y, Yoshioka S, Yao H, Takaori-Kondo A, Maekawa T, Ichinohe T.
  • Journal Title: Chimerism Volume: 4(3) Issue: 3 Pages: 78-83
  • DOI: 10.4161/chim.25609
  • Peer Reviewed
• [Journal Article] Significance of semiquantitative assessment of preformed donor-specific antibody using luminex single bead assay in living related liver transplantation (2013)
  • Author(s): Yoshizawa A, Egawa H, Yurugi K, Hishida R, Tsuji H, Ashihara E, Miyagawa-Hayashino A, Teramukai S, Maekawa T, Haga H, Uemoto S
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 972705-972705
  • DOI: 10.1155/2013/972705
  • Peer Reviewed
• [Journal Article] Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis. (2013)
  • Author(s): Itatani Y, Kawada K, Fujishita T, Kakizaki F, Hirai H, Matsumoto T, Iwamoto M, Inamoto S, Hatano E, Hasegawa S, Maekawa T, Uemoto S, Sakai Y, Taketo MM
  • Journal Title: Gastroenterol Volume: 145(5) Issue: 5 Pages: 1064-1075
  • DOI: 10.1053/j.gastro.2013.07.033
  • NAID: 120005348333
  • Peer Reviewed
• [Journal Article] Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis. (2013)
  • Author(s): 1. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
  • Journal Title: J Immunol Volume: 191 Issue: 3 Pages: 1073-1081
  • DOI: 10.4049/jimmunol.1203535
  • Peer Reviewed
• [Journal Article] Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein. (2013)
  • Author(s): Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T
  • Journal Title: Rheumatology Volume: 52(10) Issue: 10 Pages: 1769-1774
  • DOI: 10.1093/rheumatology/ket241
  • Peer Reviewed
• [Journal Article] Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population (2013)
  • Author(s): Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I,
  • Journal Title: American Journal of Human Genetics Volume: 93 Issue: 2 Pages: 289-297
  • DOI: 10.1016/j.ajhg.2013.05.024
  • Peer Reviewed
• [Journal Article] 慢性期CMLと類白血病反応に共通する分子機構 (2013)
  • Author(s): 林 嘉宏、平位秀世、前川 平
  • Journal Title: 血液内科 Volume: 67(5) Pages: 638-645
  • NAID: 40019901724
• [Journal Article] 細胞調製施設の概要と運営 (2013)
  • Author(s): 笠井泰成、前川 平
  • Journal Title: 整形・災害外科 Volume: 56(5) Pages: 451-459
• [Journal Article] 輸血療法とその副作用―見逃されている臨床病態 (2013)
  • Author(s): 万木紀美子、前川 平
  • Journal Title: 日本医事新報 Volume: 4663 Pages: 40-46
  • NAID: 10031202690
• [Journal Article] HLA抗体検査における血清非働化の必要性について-血清非働化によりHLA抗体強陽性を判定しえた２症例の経験から- (2013)
  • Author(s): 万木紀美子、前川 平
  • Journal Title: 日本輸血・細胞治療学会誌 Volume: 59(3) Pages: 462-468
  • Peer Reviewed
• [Journal Article] Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia. (2013)
  • Author(s): Katagiri S, Minami Y, Naoe T, et al.
  • Journal Title: Clin Cancer Res. Volume: 19 Issue: 6 Pages: 1422-1432
  • DOI: 10.1158/1078-0432.ccr-12-1777
  • Peer Reviewed
• [Journal Article] Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells (2013)
  • Author(s): Y. Sawai, H. Murata, M. Horii, K. Koto,T. Matsui, N. Horie, Y. Tsuji, E. Ashihara, T. Maekawa, T. Kubo, S. Fushiki
  • Journal Title: Oncol Rep Volume: 29 Issue: 3 Pages: 941-945
  • DOI: 10.3892/or.2012.2195
  • Peer Reviewed
• [Journal Article] Zoledronic acid significantly enhances radiation induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling. (2013)
  • Author(s): 8. Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S.
  • Journal Title: Int J Oncol Volume: 42 Issue: 2 Pages: 525-534
  • DOI: 10.3892/ijo.2012.1735
  • Peer Reviewed
• [Journal Article] Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL expressing leukemic cells. (2013)
  • Author(s): Okabe S
  • Journal Title: Cancer Cell International Volume: 13(1) Issue: 1 Pages: 32-40
  • DOI: 10.1186/1475-2867-13-32
  • Peer Reviewed
• [Journal Article] C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. (2013)
  • Author(s): 5. Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T.
  • Journal Title: Leukemia Volume: 27 Issue: 3 Pages: 619-628
  • DOI: 10.1038/leu.2012.258
  • NAID: 120005466670
  • Peer Reviewed
• [Journal Article] Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β. (2013)
  • Author(s): Hirai H
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: e54862-e54862
  • DOI: 10.1371/journal.pone.0054862
  • NAID: 120005242481
  • Peer Reviewed
• [Journal Article] C/EBP is involved in the amplification of early granulocyte precursors during candidemia-induced ‘emergency’ granulopoiesis. (2012)
  • Author(s): Satake S
  • Journal Title: J Immunol Volume: 198 Issue: 9 Pages: 4546-4555
  • DOI: 10.4049/jimmunol.1103007
  • Peer Reviewed
• [Journal Article] Progressive graft fibrosis and donor-specific HLA antibodies in pediatric late liver allografts (2012)
  • Author(s): Miyagawa-Hayashino A, Yoshizawa A, Uchida Y, Egawa H, Yurugi K, Masuda S, Minamiguchi S, Maekawa T, Uemoto S, Haga H
  • Journal Title: Liver Transpl Volume: 18 Issue: 11 Pages: 1333-1342
  • DOI: 10.1002/lt.23534
  • Peer Reviewed
• [Journal Article] Effects of low-intensity pulsed ultrasound (LIPUS) on osteosarcoma and cancer cells. (2012)
  • Author(s): Sawai Y
  • Journal Title: Oncol Rep Volume: 28 Issue: 2 Pages: 481-486
  • DOI: 10.3892/or.2012.1816
  • Peer Reviewed
• [Journal Article] Incidence and pattern of hemolytic anemia after minor ABO-mismatched living-donor lobar lung transplantation. (2012)
  • Author(s): Ohsumi A
  • Journal Title: Surg Today Volume: 70 (2) Pages: 211-245
  • Peer Reviewed
• [Journal Article] 造血器腫瘍の診断と治療 治療法 支持療法；輸血副作用とHLA抗体. (2012)
  • Author(s): 吉岡聡
  • Journal Title: 日本臨床 Volume: 70 (2) Pages: 211-245
• [Journal Article] 細胞周期調節系. (2012)
  • Author(s): 前川 平
  • Journal Title: 日本臨牀 Volume: 70 (suppl 8) Pages: 119-124
• [Presentation] 間葉系幹細胞と副甲状腺ホルモンを応用した造血細胞の増幅 (2014)
  • Author(s): 三浦康生、平位秀世、前川平(他7名)
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-03-08
• [Presentation] 単球造血におけるC/EBPβの機能解析 (2014)
  • Author(s): 平位秀世、田村彰広、横田明日美、佐藤淳至、岩佐磨佐紀、三浦康生、前川 平
  • Organizer: 第18回造血器腫瘍研究会(兼、がん研究開発費「がん幹細胞に対する新規分子標的治療薬の開発を目指した基盤研究」班会議)
  • Place of Presentation: 東京
• [Presentation] C/EBPβexpressed by bone marrow mesenchymal stromal cells is indispensable for precursor B-cell lymphopoiesis. American Society of Hematology (2013)
  • Author(s): Yoshioka S, Miura Y, Hirai H, Maekawa T(他7名)
  • Organizer: 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2013-12-09
• [Presentation] Direct Interaction with Bone Marrow Mesenchymal Stromal/Stem Cells Is Required for Hematopoietic Expansion by Parathyroid Hormone. American Society of Hematology (2013)
  • Author(s): Yao H , Miura Y, Hirai H, Maekawa T(他6名)
  • Organizer: 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2013-12-07
• [Presentation] Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs (2013)
  • Author(s): Yao H, Miura Y, Hirai H, Maekawa T(他7名)
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo
  • Year and Date: 2013-10-12
• [Presentation] 接着法による効率的なさい帯血からの間葉系幹細胞分離に関する検討 (2013)
  • Author(s): 吉岡聡,三浦康生,平位秀世,前川平(他3名)
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-05-17
• [Presentation] Parathyroid hormone enhances expansion through CDH11 in human bone marrow mesenchymal stromal/stem cells (2013)
  • Author(s): Yao H, Miura Y, Hirai H, Maekawa T(他5名)
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1"New Insights into Stem Cell Biology-Stem Cell Development & Differentiation"
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2013-04-19
• [Presentation] C/EBPβin mesenchymal stromal/stem cells regulates early B cell lymphopoiesis (2013)
  • Author(s): Yoshioka S, Miura Y, Hirai H, Maekawa T(他6名)
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1"New Insights into Stem Cell Biology- Stem Cell Development & Differentiation"
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2013-04-19
• [Presentation] Parathyroid hormone enhances expansion through CDH11 in human bone marrow mesenchymal stromal/stem cells. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Hayashi Y, Yokota A, Tamura A, Ichinohe T, Hirai H, Maekawa T.
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1 “New Insights into Stem Cell Biology- Stem Cell Development & Differentiation”
  • Place of Presentation: Kobe, Japan
  • Invited
• [Presentation] C/EBPβ in mesenchymal stromal/stem cells regulates early B cell lymphopoiesis. (2013)
  • Author(s): Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T. C/EBPβ in mesenchymal stromal/stem cells regulates early B cell lymphopoiesis.
  • Organizer: AsiaCORD 2013, Scientific Symposium I-1 “New Insights into Stem Cell Biology- Stem Cell Development & Differentiation”
  • Place of Presentation: Kobe, Japan
  • Invited
• [Presentation] 原発性胆汁性肝硬変患者が保有するHLA抗体について (2013)
  • Author(s): 万木紀美子、平位秀世、菱田理恵、吉澤 淳、吉岡 聡、三浦康生、芦原英司、上本伸二、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 高頻度抗原に対する不規則抗体および複合抗体陽性の肝臓移植症例への対応 ― 院内および血液センターとの連携の重要性 ― (2013)
  • Author(s): 万木紀美子、平位秀世、藤本康弘、河村朋子、樋口征昭、丹羽紀美、竹川良子、菱田理恵、三浦康生、辻 肇、上本伸二、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 転写因子C/EBPβは骨髄系分化・増殖の誘導によりCML幹細胞を減少させる (2013)
  • Author(s): 林 嘉宏、平位秀世、横田明日美、八尾尚幸、三浦康生、芦原英司、前川 平
  • Organizer: 第17回日本がん分子標的治療学会学術総会
  • Place of Presentation: 京都
• [Presentation] Myeloid-derived suppressor cells have regulatory roles in mouse collagen-induced arthritis. (2013)
  • Author(s): Fujii W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Madrid, Spain
• [Presentation] コラーゲン誘導関節炎におけるMyeloid-derived suppressor cellsは関節炎の制御に重要な役割を果たす. (2013)
  • Author(s): 藤井渉、芦原英司、平位秀世、村上憲、妹尾高宏、山本相浩、石野秀岳、河野正孝、前川平、川人豊
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
• [Presentation] Impact of donor-specific anti-HLA and anti-angiotensin-II type 1 receptor antibodies on graft fibrosis after immunosuppression withdrawal in pediatric liver transplantation. (2013)
  • Author(s): Ohe H, Uchida Y, Yoshizawa A, Hirao H, Taniguchi M, Maruya E, Maekawa T, Uemoto S, Terasaki PI.
  • Organizer: The 13th Congress of the Asian Society of Transplantation
  • Place of Presentation: Kyoto, Japan
• [Presentation] Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Hayashi Y, Tamura A, Yokota A, Ichinohe T, Tohyama K, Hirai H, Maekawa T.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] Involvement of C/EBPβ in the regulation of hematopoietic stem cells. (2013)
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Yao H, Yoshioka S, Sato A, Iwasa M, Ashihara E, Miura Y, Maekawa T.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] 高頻度抗原に対する不規則抗体（抗Jra抗体）の抗体価推移の検討 (2013)
  • Author(s): 万木紀美子、平位秀世、藤本康弘、丹羽紀実、竹川良子、菱田理恵、三浦康生、上本伸二
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌
• [Presentation] 血液疾患から考えるグリベック耐性の機序 (2013)
  • Author(s): 前川 平
  • Organizer: 第21回近畿GIST研究会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 抗甲状腺薬による無顆粒球症はHLA領域の4つの多型と関連する (2013)
  • Author(s): 寺尾知可史、吉村弘、窪田純久、渡邊奈津子、西原永潤、清水正和、川口喬久、小島裕人、万木紀美子、三浦康生、佐治博夫、前川平、山田亮、伊藤公一、宮内昭、赤水尚史、松田文彦
  • Organizer: 第56回日本甲状腺学会学術集会
  • Place of Presentation: 和歌山
• [Presentation] 抗甲状腺薬による無顆粒球症はHLA領域の4つの多型と関連する (2013)
  • Author(s): 寺尾知可史、吉村弘、窪田純久、渡邊奈津子、西原永潤、清水正和、川口喬久、小島裕人、万木紀美子、三浦康生、佐治博夫、前川平、山田亮、伊藤公一、宮内昭、赤水尚史、松田文彦
  • Organizer: 第58回日本人類遺伝子学会
  • Place of Presentation: 仙台
• [Presentation] IL12Bは高安動脈炎の新規疾患感受性遺伝子でありHLA-B*52:01と相互作用を示す (2013)
  • Author(s): 寺尾 知可史、吉藤 元, 木村 彰方, 松村 貴由, 大村 浩一郎, 成瀬 妙子, 佐藤 愛子, 前島 康浩, 和田 庸子, 成田 一衛, 川口 鎮司, 山中 寿, 前川 平, 小川 誠司, 小室 一成, 永井 良三, 田原 康玄, 磯部 光章, 三森 経世, 松田 文彦
  • Organizer: 第41回日本臨床免疫学会
  • Place of Presentation: 下関
• [Presentation] 骨髄移植症例におけるドナー由来HLA抗体への対応 (2013)
  • Author(s): 万木紀美子、三浦康生、菱田理恵、北脇年雄、錦織桃子、菱澤方勝、近藤忠一、北野俊行、芦原英司、高折晃史、平位秀世、前川平
  • Organizer: 第100回近畿血液学地方会
  • Place of Presentation: 大阪
• [Presentation] C/EBPβ expressed by bone marrow mesenchymal stromal cells is indispensable for precursor B-cell lymphopoiesis. (2013)
  • Author(s): Yoshioka S, Miura Y, Yao H, Iwasa M, Sato A, Tamura A, Yokota A, Hishita T, Ichinohe T, Hirai H, Maekawa T.
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cell-intrinsic and -extrinsic involvement of C/EBPβ in the regulation of hematopoietic stem cells. (2013)
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T.
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character. (2013)
  • Author(s): Ashihara E, Nakagawa Y, Yao H, Yokota A, Miura Y, Takata K, Kitamura Y, Hirai H, Maekawa T.
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Direct Interaction with Bone Marrow Mesenchymal Stromal/Stem Cells Is Required for Hematopoietic Expansion by Parathyroid Hormone. (2013)
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Tamura A, Yokota A, Ashihara E, Ichinohe T, Hirai H,Maekawa T.
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Mesenchymal stem cells skewed their phenotype toward the osteogenic lineage support the hematopoietic cell differentiation. American Society of Hematology (2012)
  • Author(s): Yao H, Miura Y, Hirai H, Maekawa T(他3名)
  • Organizer: 54th Annual Meeting
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] Expression of C/EBPβin bone marrow mesenchymal stem cells is mandatory for early-stage B cell lymphopoiesis. American Society of Hematology (2012)
  • Author(s): Yoshioka S, Miura Y, Hirai H, Maekawa T(他5名)
  • Organizer: 54th Annual Meeting
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] Parathyroid hormone stimulates mesenchymal stem cells to enhance expansion of hematopoietic cells (2012)
  • Author(s): Yao H, Miura Y, Hirai H, Maekawa T(他3名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Defective mesenchymal stem cells contribute to impaired B cell lymphopoiesis in C/EBPβdeficient mice (2012)
  • Author(s): Yoshioka S, Miura Y, Hirai H, Maekawa T(他5名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Successful co-treatment of BCR-ABL leukemic cells with ponatinib, an ABL kinase inhibitor, and vorinostat, a histone deacetylase inhibitor: A potential treatment for BCR-ABL positive leukemia cells. (2012)
  • Author(s): Okabe S
  • Organizer: 17th Congress of European Society of Hematology
  • Place of Presentation: Amsterdam, The Netherland
• [Presentation] An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal-product free medium in patients with diabetic foot ulcers. (2012)
  • Author(s): Morimoto N
  • Organizer: 4th Congress of the World Union of Wound Healing Societies
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] Myeloid-derived suppressor cells accumulated in spleens of mice with collagen-induced arthritis and inhibited immune response of CD4+ T cells. (2012)
  • Author(s): Fujii W
  • Organizer: American College of Rheumatology 2012 Annual Scientific Meeting
  • Place of Presentation: Washington, DC, USA
• [Presentation] C/EBPβ-mediated expansion of hematopoietic stem/progenitors precedes ‘emergency’ granulopoiesis induced by candidemia. (2012)
  • Author(s): Tamura A
  • Organizer: The 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] Expression of C/EBPβ in Bone Marrow Mesenchymal Stem Cells Is Mandatory for Early-Stage B Cell Lymphopoiesis. (2012)
  • Author(s): Yoshioka S
  • Organizer: The 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] Mesenchymal stem cells skewed their phenotype toward the osteogenic lineage support the hematopoietic cell differentiation. (2012)
  • Author(s): Yao H
  • Organizer: The 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] C/EBPβ is upregulated through STAT5 and accelerates exhaustion of leukemic stem cells in chronic phase of chronic myeloid leukemia. (2012)
  • Author(s): Hayashi Y
  • Organizer: The 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA, USA
• [Presentation] BCR/ABLの白血病原性における転写因子 C/EBPβの関与. (2012)
  • Author(s): 林 嘉宏
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場(福岡県)
• [Presentation] 新規Wnt/beta-カテニン経路阻害剤AV65による多発性骨髄腫細胞の増殖抑制効果. (2012)
  • Author(s): 芦原英司
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
• [Presentation] Parathyroid hormone stimulates mesenchymal stem cells to enhance expansion of hematopoietic cells. (2012)
  • Author(s): Yao H
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 国際会議場(京都府)
• [Presentation] Defective mesenchymal stem cells contribute to impaired B cell lymphopoiesis in C/EBPb knockout mice. (2012)
  • Author(s): Yoshioka S
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 国際会議場(京都府)
• [Presentation] Co-treatment with ponatinib and HDAC inhibitor vorinostat: A treatment for Ph-positive cells. (2012)
  • Author(s): Okabe S
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 国際会議場(京都府)
• [Presentation] Targeting the Hedgehog pathway in therapy-resistant BCR-ABL1 positive leukemia with ponatinib. (2012)
  • Author(s): Katagiri S
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 国際会議場(京都府)
• [Presentation] Combined effects of ponatinib and dasatinib against T315I mutant forms of BCR-ABL1. (2012)
  • Author(s): Tauchi T
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 国際会議場(京都府)
• [Remarks]
  • URL: http://dtm.kuhp.kyoto-u.ac.jp