| Project/Area Number |
24659470
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|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197)
|
|---|
| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | アレルギー / 免疫 |
|---|
| Research Abstract |
IL-33 induces Th2 cytokines by various types of cells through its receptors, ST2 and IL-1RAcP. In certain immune responses, the phenotypes are known to be inconsistent between IL-33-deficient and ST2-deficient mice, suggesting the existence of the other receptor(s) for IL-33 and/or the other ligand(s) for ST2. In the study, we attempted to identify the binding molecule(s) of IL-33.
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