| Project/Area Number |
24659478
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 抗菌薬 / 短時間殺菌能 / 精密粒度分布測定 |
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| Outline of Final Research Achievements |
For evaluating of short-time antimicrobial activities of antibiotics, we assessed the usefulness of a new method, which could detect changes in diameters of the bacteria in real-time by measuring particle size distribution. We prepared clinical isolates of MRSA, and compared the antimicrobial activities of WAP-8294A2 (WAP) and vancomycin (VCM), through the decrease in viable bacterial counts, the changes in diameters of the bacteria by measuring particle size distribution. Changes in mean diameters of MRSA were simultaneously detected in the extremely short-time, which corresponded with the decrease in viable bacterial counts. This suggested the usefulness of measuring particle size distribution in the evaluation of short-time antimicrobial activities of antibiotics.
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